ES2159484A1 - Derivados de glicosil-diacil dopamina y sus sales como agentes potenciales de reposicion de dopamina en cerebro y su procedimiento de obtencion. - Google Patents

Derivados de glicosil-diacil dopamina y sus sales como agentes potenciales de reposicion de dopamina en cerebro y su procedimiento de obtencion.

Info

Publication number
ES2159484A1
ES2159484A1 ES9902827A ES9902827A ES2159484A1 ES 2159484 A1 ES2159484 A1 ES 2159484A1 ES 9902827 A ES9902827 A ES 9902827A ES 9902827 A ES9902827 A ES 9902827A ES 2159484 A1 ES2159484 A1 ES 2159484A1
Authority
ES
Spain
Prior art keywords
dopamine
glycosyl
dicarboxylic acid
bonding
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9902827A
Other languages
English (en)
Other versions
ES2159484B1 (es
Inventor
Lozano Caridad Fernandez
Alvarez Al Fernandez-Mayoralas
Lopez Ofelia Nieto
Gil Jose Angel Fontela
Torres Emilia Rivas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Santiago de Compostela
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Universidade de Santiago de Compostela
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade de Santiago de Compostela, Consejo Superior de Investigaciones Cientificas CSIC filed Critical Universidade de Santiago de Compostela
Priority to ES9902827A priority Critical patent/ES2159484B1/es
Publication of ES2159484A1 publication Critical patent/ES2159484A1/es
Application granted granted Critical
Publication of ES2159484B1 publication Critical patent/ES2159484B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Derivados de glicosil-diacil dopamina y sus sales como agentes potenciales de reposición de dopamina en cerebro y su procedimiento de obtención. La hipótesis de la invención se fundamenta en la capacidad de un residuo glucídico para actuar como un vector que transporte al neurotransmisor hacia el interior del tejido cerebral, en donde se liberaría gradualmente dopamina por hidrólisis de la unión glúcido-dopamina. Los compuestos presentan la dopamina unida a una hexosa a través de un conector derivado de un ácido dicarboxílico. Las uniones tienen lugar mediante enlaces susceptibles de ser hidrolizados por enzimas hidrolasas presentes en tejido cerebral, tales como esteraras y proteasas. Poseen utilidad potencial con nuevos agentes terapéuticos en el tratamiento de enfermedades caracterizadas por bajos niveles de dopamina, como la enfermedad de Parkinson.
ES9902827A 1999-12-22 1999-12-22 Derivados de glicosil-diacil dopamina y sus sales como agentes potenciales de reposicion de dopamina en cerebro y su procedimiento de obtencion. Expired - Fee Related ES2159484B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9902827A ES2159484B1 (es) 1999-12-22 1999-12-22 Derivados de glicosil-diacil dopamina y sus sales como agentes potenciales de reposicion de dopamina en cerebro y su procedimiento de obtencion.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9902827A ES2159484B1 (es) 1999-12-22 1999-12-22 Derivados de glicosil-diacil dopamina y sus sales como agentes potenciales de reposicion de dopamina en cerebro y su procedimiento de obtencion.

Publications (2)

Publication Number Publication Date
ES2159484A1 true ES2159484A1 (es) 2001-10-01
ES2159484B1 ES2159484B1 (es) 2002-05-01

Family

ID=8311038

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9902827A Expired - Fee Related ES2159484B1 (es) 1999-12-22 1999-12-22 Derivados de glicosil-diacil dopamina y sus sales como agentes potenciales de reposicion de dopamina en cerebro y su procedimiento de obtencion.

Country Status (1)

Country Link
ES (1) ES2159484B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102993256A (zh) * 2012-12-31 2013-03-27 浙江大学 一种选择性脱除全三甲基硅基保护糖的伯位三甲基硅基的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0564099A1 (en) * 1992-03-09 1993-10-06 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Alpha-glycosyl derivative of catecholamine or its salt, and its preparation and uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0564099A1 (en) * 1992-03-09 1993-10-06 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Alpha-glycosyl derivative of catecholamine or its salt, and its preparation and uses

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HALMOS, T. y col. Synthesis of glucose-chlorambucil derivatives and their recognition by the human GLUT1 glucose transporter. European Journal of Pharmacology, 1996, Vol. 318, paginas 477-484. *
POLT, R. y col. Glycopeptide enkephalin analogues produce analgesia in mice: Evidence for penetration of the blood-brain barrier. Proc. Natl. Acad. Sci. USA. Julio 1994, Vol. 91, paginas 7114-7118. *
URIEL, C. y col. Hexose Keto-C-glycoside Conjugates: Design, Synthesis, Cytotoxicity, and Evaluation of Their Affinity for the Glucose Transporter Glut-1. Bioorganic & Medicinal Chemistry, 1996, Vol. 4, No 12, paginas 2081-2090. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102993256A (zh) * 2012-12-31 2013-03-27 浙江大学 一种选择性脱除全三甲基硅基保护糖的伯位三甲基硅基的方法
CN102993256B (zh) * 2012-12-31 2016-05-18 浙江大学 一种选择性脱除全三甲基硅基保护糖的伯位三甲基硅基的方法

Also Published As

Publication number Publication date
ES2159484B1 (es) 2002-05-01

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