ES2157294T3 - Inhibidor y anticuerpos monoclonales anti-inhibidores especificos de la peroxidasa de rabano picante. - Google Patents

Inhibidor y anticuerpos monoclonales anti-inhibidores especificos de la peroxidasa de rabano picante.

Info

Publication number
ES2157294T3
ES2157294T3 ES95303657T ES95303657T ES2157294T3 ES 2157294 T3 ES2157294 T3 ES 2157294T3 ES 95303657 T ES95303657 T ES 95303657T ES 95303657 T ES95303657 T ES 95303657T ES 2157294 T3 ES2157294 T3 ES 2157294T3
Authority
ES
Spain
Prior art keywords
rabano
peroxidase
antibodies
monoclonal antibodies
picante
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95303657T
Other languages
English (en)
Inventor
Kevin M Gorman
John L Daiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Ortho Clinical Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Clinical Diagnostics Inc filed Critical Ortho Clinical Diagnostics Inc
Application granted granted Critical
Publication of ES2157294T3 publication Critical patent/ES2157294T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

SE HAN PREPARADO ANTICUERPOS MONOCLONALES QUE SON DEL ISOTOPO IGG Y SON ALTAMENTE ESPECIFICOS PARA LA PEROXIDASA DEL RABANO PICANTE. UN GRUPO DE ANTICUERPOS INHIBE AL MENOS ALREDEDOR DE UN 95% DE LA ACTIVIDAD NORMAL DE LA PEROXIDASA DEL RABANO PICANTE CUANDO SE UNEN A LA ENZIMA. UN SEGUNDO GRUPO DE ANTICUERPOS INHIBE MENOS DE UN 20% DE LA ACTIVIDAD ENZIMATICA CUANDO SE UNEN A LA ENZIMA, PERO EVITAN LA UNION DE LOS ANTICUERPOS DEL PRIMER GRUPO. LOS ANTICUERPOS DE CUALQUIER GRUPO PUEDEN CONJUGARSE CON LIGANTES DE UNION ESPECIFICA TALES COMO DROGAS U HORMONAS.
ES95303657T 1994-05-31 1995-05-30 Inhibidor y anticuerpos monoclonales anti-inhibidores especificos de la peroxidasa de rabano picante. Expired - Lifetime ES2157294T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/251,496 US5650324A (en) 1994-05-31 1994-05-31 Inhibitor and anti-inhibitor monoclonal antibodies specific for horseradish peroxidase

Publications (1)

Publication Number Publication Date
ES2157294T3 true ES2157294T3 (es) 2001-08-16

Family

ID=22952229

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95303657T Expired - Lifetime ES2157294T3 (es) 1994-05-31 1995-05-30 Inhibidor y anticuerpos monoclonales anti-inhibidores especificos de la peroxidasa de rabano picante.

Country Status (11)

Country Link
US (1) US5650324A (es)
EP (1) EP0690071B1 (es)
JP (1) JP3745411B2 (es)
AU (1) AU2040995A (es)
CA (1) CA2150497C (es)
DE (1) DE69519699T2 (es)
DK (1) DK0690071T3 (es)
ES (1) ES2157294T3 (es)
GR (1) GR3035547T3 (es)
PT (1) PT690071E (es)
SI (1) SI0690071T1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916757A (en) * 1994-05-31 1999-06-29 Johnson & Johnson Clinical Diagnostics, Inc. Specific binding assay using enzyme inhibitor and anti-inhibitor antibodies
CA2283597C (en) 1998-10-02 2008-02-05 Ortho-Clinical Diagnostics, Inc. Reduced cortisol conjugates
US7183119B2 (en) * 2004-11-15 2007-02-27 Eastman Kodak Company Method for sensitive detection of multiple biological analytes
US7348147B2 (en) * 2004-11-15 2008-03-25 Carestream Health, Inc. Method and system for nucleic acid detection
US7074622B2 (en) * 2004-11-15 2006-07-11 Eastman Kodak Company Method and system for sorting and separating particles

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD243185A (es) *
DE230936C (es) *
DE243185C (es) *
JPS58209994A (ja) * 1982-05-10 1983-12-07 Fujirebio Inc 活性蛋白等固定化物を用いた抗原の測定方法
EP0119767B1 (en) * 1983-03-11 1990-11-22 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Method of measuring ligands
CA1231067A (en) * 1983-08-16 1988-01-05 Bioclones (Proprietary) Limited Monoclonal antibody to peroxidase and hybridoma producing it
NL8501219A (nl) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
US5085988A (en) * 1986-09-05 1992-02-04 Syntex (U.S.A.) Inc. Immunoseparating strip
ES2148144T3 (es) * 1990-11-20 2000-10-16 Dade Behring Marburg Gmbh Procedimiento para la estabilizacion de conjugados de enzima.
EP0517327B1 (en) 1991-06-07 2001-08-16 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassay with labeled hapten analogues

Also Published As

Publication number Publication date
DK0690071T3 (da) 2001-01-29
US5650324A (en) 1997-07-22
JPH0853497A (ja) 1996-02-27
SI0690071T1 (en) 2001-06-30
PT690071E (pt) 2001-04-30
CA2150497C (en) 2006-10-17
AU2040995A (en) 1995-12-07
EP0690071A3 (en) 1996-10-16
DE69519699T2 (de) 2001-04-26
GR3035547T3 (en) 2001-06-29
EP0690071B1 (en) 2000-12-27
JP3745411B2 (ja) 2006-02-15
EP0690071A2 (en) 1996-01-03
DE69519699D1 (de) 2001-02-01
CA2150497A1 (en) 1995-12-01

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