ES2156725A1 - Fused 1,2,6-thiadiazine -n,n and n,x-disubstituted dioxide derivatives and corresponding production method - Google Patents

Fused 1,2,6-thiadiazine -n,n and n,x-disubstituted dioxide derivatives and corresponding production method

Info

Publication number
ES2156725A1
ES2156725A1 ES009900954A ES9900954A ES2156725A1 ES 2156725 A1 ES2156725 A1 ES 2156725A1 ES 009900954 A ES009900954 A ES 009900954A ES 9900954 A ES9900954 A ES 9900954A ES 2156725 A1 ES2156725 A1 ES 2156725A1
Authority
ES
Spain
Prior art keywords
thiadiazine
disubstituted
fused
production method
corresponding production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009900954A
Other languages
Spanish (es)
Other versions
ES2156725B1 (en
Inventor
Gil Ana Martinez
Ayuso-Gontan Carmen Gil
Castro Ana Morera
Martin M Concepcion Perez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES9900954A priority Critical patent/ES2156725B1/en
Priority to PCT/ES2000/000165 priority patent/WO2000068216A1/en
Priority to AU44063/00A priority patent/AU4406300A/en
Publication of ES2156725A1 publication Critical patent/ES2156725A1/en
Application granted granted Critical
Publication of ES2156725B1 publication Critical patent/ES2156725B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to compounds of general formula (I, II and III) and to a method for the production thereof, whereby compounds (III) are initially obtained in a first step and compounds (I and II) are obtained in a second step. Said compounds can be applied in the field of opportunistic viral infections in immunocompromised patients.
ES9900954A 1999-05-07 1999-05-07 DERIVATIVES OF DIOXIDES N, N- AND N, X-DISUSTITUTES OF 1,2,6-TIADIAZINE FUSED AND PROCEDURE OF OBTAINING. Expired - Fee Related ES2156725B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9900954A ES2156725B1 (en) 1999-05-07 1999-05-07 DERIVATIVES OF DIOXIDES N, N- AND N, X-DISUSTITUTES OF 1,2,6-TIADIAZINE FUSED AND PROCEDURE OF OBTAINING.
PCT/ES2000/000165 WO2000068216A1 (en) 1999-05-07 2000-05-05 Fused 1,2,6-thiadiazine -n,n and n,x-disubstituted dioxide derivatives and corresponding production method
AU44063/00A AU4406300A (en) 1999-05-07 2000-05-05 Fused 1,2,6-thiadiazine -LTiGTn,nLT/iGT and LTiGTn,xLT/iGT-disubstituted dioxidederivatives and corresponding production method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9900954A ES2156725B1 (en) 1999-05-07 1999-05-07 DERIVATIVES OF DIOXIDES N, N- AND N, X-DISUSTITUTES OF 1,2,6-TIADIAZINE FUSED AND PROCEDURE OF OBTAINING.

Publications (2)

Publication Number Publication Date
ES2156725A1 true ES2156725A1 (en) 2001-07-01
ES2156725B1 ES2156725B1 (en) 2002-03-01

Family

ID=8308292

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9900954A Expired - Fee Related ES2156725B1 (en) 1999-05-07 1999-05-07 DERIVATIVES OF DIOXIDES N, N- AND N, X-DISUSTITUTES OF 1,2,6-TIADIAZINE FUSED AND PROCEDURE OF OBTAINING.

Country Status (3)

Country Link
AU (1) AU4406300A (en)
ES (1) ES2156725B1 (en)
WO (1) WO2000068216A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0608928D0 (en) 2006-05-08 2006-06-14 Angeletti P Ist Richerche Bio Therapeutic agents
WO2008073958A2 (en) 2006-12-12 2008-06-19 Wyeth Substituted benzothiadiazinedioxide derivatives and methods of their use
CN101754970B (en) 2007-07-17 2013-07-10 P.安杰莱蒂分子生物学研究所 Macrocyclic indole derivatives for the treatment of hepatitis c infections

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1596384A (en) * 1976-12-11 1981-08-26 Basf Ag N,n'-disubstituted -2,1,3-benzothiadizin-(4)-one derivatives and their use as herbicides
WO1999037643A1 (en) * 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1596384A (en) * 1976-12-11 1981-08-26 Basf Ag N,n'-disubstituted -2,1,3-benzothiadizin-(4)-one derivatives and their use as herbicides
WO1999037643A1 (en) * 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry Letters, Vol. 7, no 8, paginas 1031-1032, 1997. A. MARTINEZ et al. "Benzothiadiazine Dioxide Acyclonucleosides as Lead Compounds for the Development of New Agents Against Human Cytomegalovirus and Varicella-Zoster Virus Infections". Todo el documento. *
Bioorganic & Medicinal Chemistry, Vol. 3, paginas 1527-1535, 1995. A. MARTINEZ et al. "New 1,2,6-Thiadiazine Dioxide Acyclonucleosides: Synthesis and Antiviral Evaluation". *
Nucleosides Nucleotides, Vol. 16, paginas 265-276, 1997. A.I. ESTEBAN et al. "Synthesis and Antiviral Activity of Modified 1,2,6-thiadiazine Dioxide Acyclonucleosides". *

Also Published As

Publication number Publication date
WO2000068216A1 (en) 2000-11-16
ES2156725B1 (en) 2002-03-01
AU4406300A (en) 2000-11-21

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