ES2156534B1 - NEW INHIBITORS OF INTERACTION BETWEEN INTERLEUQUINA-8 AND ITS RECEPTORS - Google Patents

NEW INHIBITORS OF INTERACTION BETWEEN INTERLEUQUINA-8 AND ITS RECEPTORS

Info

Publication number
ES2156534B1
ES2156534B1 ES9900218A ES9900218A ES2156534B1 ES 2156534 B1 ES2156534 B1 ES 2156534B1 ES 9900218 A ES9900218 A ES 9900218A ES 9900218 A ES9900218 A ES 9900218A ES 2156534 B1 ES2156534 B1 ES 2156534B1
Authority
ES
Spain
Prior art keywords
receptors
interaction
interleuquina
new inhibitors
interleukin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9900218A
Other languages
Spanish (es)
Other versions
ES2156534A1 (en
Inventor
Steve W Elson
Monedero Emilio Diez
Jose Maria Sanchez-Puelles
Rodriguez Juan Antonio Hueso
Jadu Manuel Valmaseda
La Fuente Carralero Jesus De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham SA
Original Assignee
SmithKline Beecham SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham SA filed Critical SmithKline Beecham SA
Priority to ES9900218A priority Critical patent/ES2156534B1/en
Publication of ES2156534A1 publication Critical patent/ES2156534A1/en
Application granted granted Critical
Publication of ES2156534B1 publication Critical patent/ES2156534B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nuevos inhibidores de la interacción entre la interleuquina-8 y sus receptores. La invención describe nuevos isómeros ópticos de la fórmula (A), en donde el carbón indicado con un asterisco puede tener una estereoquímica variable, y su uso como un inhibidor de la unión entre la interleuquina-8 y sus receptores. Los compuestos son producidos mediante la fermentación del hongo Aspergillus carneus y son útiles en el tratamiento de una variedad de enfermedades inflamatorias.New inhibitors of the interaction between interleukin-8 and its receptors. The invention describes new optical isomers of the formula (A), wherein the carbon indicated with an asterisk can have a variable stereochemistry, and its use as a binding inhibitor between interleukin-8 and its receptors. The compounds are produced by fermenting the fungus Aspergillus carneus and are useful in the treatment of a variety of inflammatory diseases.

ES9900218A 1999-02-03 1999-02-03 NEW INHIBITORS OF INTERACTION BETWEEN INTERLEUQUINA-8 AND ITS RECEPTORS Expired - Fee Related ES2156534B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9900218A ES2156534B1 (en) 1999-02-03 1999-02-03 NEW INHIBITORS OF INTERACTION BETWEEN INTERLEUQUINA-8 AND ITS RECEPTORS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9900218A ES2156534B1 (en) 1999-02-03 1999-02-03 NEW INHIBITORS OF INTERACTION BETWEEN INTERLEUQUINA-8 AND ITS RECEPTORS

Publications (2)

Publication Number Publication Date
ES2156534A1 ES2156534A1 (en) 2001-06-16
ES2156534B1 true ES2156534B1 (en) 2002-02-01

Family

ID=8307178

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9900218A Expired - Fee Related ES2156534B1 (en) 1999-02-03 1999-02-03 NEW INHIBITORS OF INTERACTION BETWEEN INTERLEUQUINA-8 AND ITS RECEPTORS

Country Status (1)

Country Link
ES (1) ES2156534B1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448379B1 (en) * 1993-09-14 2002-09-10 Chiron Corporation IL8 inhibitors

Also Published As

Publication number Publication date
ES2156534A1 (en) 2001-06-16

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20120618