ES2150888T1 - Diagnosis y tratamiento de la disenteria bacteriana. - Google Patents
Diagnosis y tratamiento de la disenteria bacteriana.Info
- Publication number
- ES2150888T1 ES2150888T1 ES00101263T ES00101263T ES2150888T1 ES 2150888 T1 ES2150888 T1 ES 2150888T1 ES 00101263 T ES00101263 T ES 00101263T ES 00101263 T ES00101263 T ES 00101263T ES 2150888 T1 ES2150888 T1 ES 2150888T1
- Authority
- ES
- Spain
- Prior art keywords
- gal
- beta
- treatment
- slt
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56916—Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Abstract
Uso de un agente en la preparación de un medicamento para la prevención o tratamiento de una infección entérica mediada por una SLT, en donde dicho agente es un soporte de afinidad inerte, sólido, farmacéuticamente aceptable, capaz de ser eliminado del tracto gastrointestinal, cuyo soporte tiene un ligando de afinidad enlazado covalentemente al mismo a través de un brazo separador, y en donde dicho ligando se caracteriza como un oligosacárido que contiene la subunidad disacárida Alfa Gal(1-4)Beta Gal que se une a la SLT; con la condición de que el disacárido no forma parte de un trisacárido Alfa Gal(1-4)Beta Gal(1-4)Beta GlcNAc o de un trisacárido Alfa Gal(1-4)Beta Gal(1-4)Beta Glc.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77873291A | 1991-10-18 | 1991-10-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2150888T1 true ES2150888T1 (es) | 2000-12-16 |
Family
ID=25114261
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00101263T Pending ES2150888T1 (es) | 1991-10-18 | 1992-10-19 | Diagnosis y tratamiento de la disenteria bacteriana. |
ES92922817T Expired - Lifetime ES2154265T3 (es) | 1991-10-18 | 1992-10-19 | Tratamiento de la disenteria bacteriana. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92922817T Expired - Lifetime ES2154265T3 (es) | 1991-10-18 | 1992-10-19 | Tratamiento de la disenteria bacteriana. |
Country Status (9)
Country | Link |
---|---|
US (3) | US5620858A (es) |
EP (2) | EP0610356B1 (es) |
AT (1) | ATE198991T1 (es) |
CA (1) | CA2121604C (es) |
DE (2) | DE1018342T1 (es) |
DK (1) | DK0610356T3 (es) |
ES (2) | ES2150888T1 (es) |
GR (1) | GR3035665T3 (es) |
WO (1) | WO1993008209A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993008209A1 (en) * | 1991-10-18 | 1993-04-29 | Chembiomed Ltd. | Diagnosis and treatment of bacterial dysentery |
US5484773A (en) * | 1994-02-14 | 1996-01-16 | Alberta Research Council | Treatment of antibiotic associated diarrhea |
US5627163A (en) * | 1995-06-05 | 1997-05-06 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
US5661131A (en) * | 1995-06-05 | 1997-08-26 | Synsorb Biotech, Inc. | Treatment of cholera |
US5811409A (en) * | 1995-06-05 | 1998-09-22 | Synsorb Biotech, Inc. | Treatment of cholera |
US5637576A (en) * | 1995-06-05 | 1997-06-10 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
US6069137A (en) * | 1996-03-11 | 2000-05-30 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
US5891860A (en) * | 1996-03-11 | 1999-04-06 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
JPH107575A (ja) * | 1996-06-21 | 1998-01-13 | Synsorb Biotec Inc | 細菌性赤痢の処置 |
CN1209752A (zh) * | 1996-06-21 | 1999-03-03 | 辛索尔布生物技术有限公司 | 用于中和大肠杆菌毒素的寡糖的用途 |
US5846943A (en) * | 1996-11-08 | 1998-12-08 | Synsorb Biotech, Inc. | Solid support matricles containing a toxin binding oligosaccharide |
US6013634A (en) * | 1996-11-08 | 2000-01-11 | Synsorb Biotech, Inc. | Solid support matrices containing a toxin binding oligosaccharide |
US5910579A (en) * | 1997-01-10 | 1999-06-08 | Synsorb Biotech Inc. | Processes for the preparation of αGal(1->4)βGal (1->4) Glc-OR |
US5888750A (en) * | 1997-05-30 | 1999-03-30 | Synsorb Biotech, Inc. | Method of recovering shiga-like toxins and vaccines comprising inactivated shiga-like toxin |
ZA991410B (en) | 1998-02-23 | 1999-10-06 | Synsorb Biotech Inc | Compounds and methods for the treatment of bacterial dysentry using antibiotics and toxin binding oligosaccharide compositions. |
NZ508172A (en) | 1998-04-15 | 2003-08-29 | Univ Utah State | Real time detection of antigens |
US7220596B2 (en) * | 1998-04-15 | 2007-05-22 | Utah State University | Real time detection of antigens |
US6310043B1 (en) | 1998-08-07 | 2001-10-30 | Governors Of The University Of Alberta | Treatment of bacterial infections |
US5962423A (en) * | 1998-08-07 | 1999-10-05 | The Governors Of The University Of Alberta | Treatment of bacterial dysentery |
US7135173B2 (en) * | 2000-07-13 | 2006-11-14 | Idaho Research Foundation, Inc. | Antiviral activity of Shiga toxin |
US6541013B1 (en) | 2000-07-13 | 2003-04-01 | Idaho Research Foundation, Inc. | Methods and compositions for suppressing bovine leukemia virus with a Shiga toxin polypeptide |
US20060051440A1 (en) * | 2002-09-10 | 2006-03-09 | Joel Moss | Factors that bind intestinal toxins |
BE1019290A5 (nl) * | 2010-04-14 | 2012-05-08 | Nutrition Sciences Nv Sa | Voedingsupplement omvattende oligosachariden en middellange keten vetzuren. |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4347244A (en) * | 1979-03-16 | 1982-08-31 | Societe Anonyme Dite: Institut Merieux | Ganglioside containing compositions for treating diarrhea |
SE8001748L (sv) * | 1980-03-05 | 1981-09-06 | Kaellenius Gunilla | Kompositioner for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutik |
EP0058665B1 (en) * | 1980-05-09 | 1986-02-26 | LEFFLER, Hakon | Carbohydrate derivatives for inhibiting bacterial adherence |
US4366241A (en) * | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
AU561067B2 (en) * | 1982-03-22 | 1987-04-30 | Biocarb Ab | Anti-bacterial composition containing an oligosaccharide |
US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
SE8406626D0 (sv) * | 1984-12-27 | 1984-12-27 | Bio Carb Ab | Forening och komposition for terapeutisk eller diagnostisk anvendning jemte anvendning av sadan forening och komposition for terapeutisk behandling och isolering av shigatoxin |
US4946943A (en) * | 1985-06-20 | 1990-08-07 | Will Bloch | Purification of ribotoxins and their conjugates |
US4863852A (en) * | 1985-07-03 | 1989-09-05 | Virginia Tech Intellectual Properties, Inc. | Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors |
US5164298A (en) * | 1988-06-24 | 1992-11-17 | Hsc Research Development Corporation | Verocytotoxin receptor assay |
US5168063A (en) * | 1990-07-27 | 1992-12-01 | Wisconsin Alumni Research Foundation | Monoclonal antibody to enterohemorrhagic escherichia coli 0157:h7 and 026:h11 |
WO1993008209A1 (en) * | 1991-10-18 | 1993-04-29 | Chembiomed Ltd. | Diagnosis and treatment of bacterial dysentery |
AU667533B2 (en) * | 1992-03-26 | 1996-03-28 | Microcarb, Inc. | Monospecific polyclonal antibodies to shiga-like toxins |
US5484773A (en) * | 1994-02-14 | 1996-01-16 | Alberta Research Council | Treatment of antibiotic associated diarrhea |
-
1992
- 1992-10-19 WO PCT/US1992/008929 patent/WO1993008209A1/en active IP Right Grant
- 1992-10-19 AT AT92922817T patent/ATE198991T1/de not_active IP Right Cessation
- 1992-10-19 DK DK92922817T patent/DK0610356T3/da active
- 1992-10-19 EP EP92922817A patent/EP0610356B1/en not_active Expired - Lifetime
- 1992-10-19 EP EP00101263A patent/EP1018342A3/en not_active Withdrawn
- 1992-10-19 ES ES00101263T patent/ES2150888T1/es active Pending
- 1992-10-19 DE DE1018342T patent/DE1018342T1/de active Pending
- 1992-10-19 DE DE69231675T patent/DE69231675T2/de not_active Expired - Fee Related
- 1992-10-19 ES ES92922817T patent/ES2154265T3/es not_active Expired - Lifetime
- 1992-10-19 CA CA002121604A patent/CA2121604C/en not_active Expired - Fee Related
-
1993
- 1993-09-27 US US08/126,645 patent/US5620858A/en not_active Expired - Fee Related
-
1995
- 1995-05-30 US US08/453,775 patent/US5679653A/en not_active Expired - Fee Related
-
1997
- 1997-06-04 US US08/868,929 patent/US5955449A/en not_active Expired - Fee Related
-
2001
- 2001-03-29 GR GR20010400515T patent/GR3035665T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1993008209A1 (en) | 1993-04-29 |
EP1018342A2 (en) | 2000-07-12 |
EP0610356A1 (en) | 1994-08-17 |
DE1018342T1 (de) | 2001-01-11 |
ATE198991T1 (de) | 2001-02-15 |
EP0610356B1 (en) | 2001-01-31 |
CA2121604A1 (en) | 1993-04-29 |
US5679653A (en) | 1997-10-21 |
EP1018342A3 (en) | 2001-04-11 |
ES2154265T3 (es) | 2001-04-01 |
DE69231675T2 (de) | 2001-06-28 |
CA2121604C (en) | 2002-01-15 |
GR3035665T3 (en) | 2001-06-29 |
DE69231675D1 (de) | 2001-03-08 |
DK0610356T3 (da) | 2001-02-19 |
US5955449A (en) | 1999-09-21 |
EP0610356A4 (en) | 1995-03-29 |
US5620858A (en) | 1997-04-15 |
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