ES2149958T3 - Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos. - Google Patents
Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos.Info
- Publication number
- ES2149958T3 ES2149958T3 ES95903342T ES95903342T ES2149958T3 ES 2149958 T3 ES2149958 T3 ES 2149958T3 ES 95903342 T ES95903342 T ES 95903342T ES 95903342 T ES95903342 T ES 95903342T ES 2149958 T3 ES2149958 T3 ES 2149958T3
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical preparations
- dihydropyridines
- condensed
- production
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
COMPUESTO DE FORMULA GENERAL (I). EN DONDE A ES UN RESTO BENZO, INDOL O TIENO, B ES EL GRUPO -O-, -S- O -CHR{SUP,5}, SIENDO R{SUP,5} HIDROGENO, ALQUILO(C{SUB,1}-C{SUB,6}, FENILO O BENZILO; R{SUP,3} 2- O 3-TIENILO, CICLOALQUILO(C{SUB,4}-C{SUB,7}), CICLOALQUILO(C{SUB,4}-C{SUB,6})ALQUILO(C{SUB,1}-C{SUB,5}), O ES (1 O (2), EN DONDE R ES ALQUILO(C{SUB,1}-C{SUB,4}), HIDROXI, N{SUB,3}, HALOGENO (F, CL, BR, I), CF{SUB,3} O ALCOXI(C{SUB,1}C{SUB,4}), U ES 0, 1, 2 O 3, Y M, R{SUP,2}, R{SUP,4}, R{SUP,7}, R{SUP,8} SE DEFINEN EN LA DESCRIPCION, Y LAS PREPARACIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS Y SU UTILIZACION FARMACEUTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4343683A DE4343683A1 (de) | 1993-12-21 | 1993-12-21 | Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2149958T3 true ES2149958T3 (es) | 2000-11-16 |
Family
ID=6505671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95903342T Expired - Lifetime ES2149958T3 (es) | 1993-12-21 | 1994-12-14 | Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos. |
Country Status (18)
Country | Link |
---|---|
US (3) | US5661157A (es) |
EP (1) | EP0736011B1 (es) |
JP (1) | JPH09506882A (es) |
CN (1) | CN1044905C (es) |
AT (1) | ATE194978T1 (es) |
AU (1) | AU699208B2 (es) |
CA (1) | CA2178209A1 (es) |
CO (1) | CO4340626A1 (es) |
DE (2) | DE4343683A1 (es) |
DK (1) | DK0736011T3 (es) |
ES (1) | ES2149958T3 (es) |
GR (1) | GR3034656T3 (es) |
PL (1) | PL315054A1 (es) |
PT (1) | PT736011E (es) |
RU (1) | RU2136664C1 (es) |
TW (1) | TW404941B (es) |
WO (1) | WO1995017389A1 (es) |
ZA (1) | ZA9410115B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4343683A1 (de) * | 1993-12-21 | 1995-06-22 | Boehringer Ingelheim Kg | Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen |
RU2524345C2 (ru) * | 2011-06-29 | 2014-07-27 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ПГФА Росздрава) | Способ получения гидрохлоридов 3-метил-6,7-диалкокси-3,4-дигидроизохинолина на основе эвгенола |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US32519A (en) * | 1861-06-11 | Improvement in hem ming-gui des | ||
HU178454B (en) * | 1979-07-02 | 1982-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new isoquinoline derivatives containing sulphur |
US4425349A (en) * | 1979-07-02 | 1984-01-10 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Sulfur-containing isoquinoline derivatives in pharmaceutical compositions and methods of use |
USRE32519E (en) * | 1979-07-02 | 1987-10-13 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara | Sulfur-containing isoquinoline derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
DE3013906A1 (de) * | 1980-04-11 | 1981-10-15 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung |
DE3621413A1 (de) * | 1986-06-26 | 1988-01-07 | Boehringer Ingelheim Kg | Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung |
IL86131A0 (en) * | 1987-04-24 | 1988-11-15 | Boehringer Ingelheim Kg | Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
DE3827727A1 (de) * | 1988-08-16 | 1990-02-22 | Boehringer Ingelheim Kg | Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion |
US5076993A (en) * | 1990-01-12 | 1991-12-31 | Science Applications International Corporation | Contraband detection system using direct imaging pulsed fast neutrons |
DE9017900U1 (es) * | 1990-12-22 | 1993-01-28 | Boehringer Ingelheim Kg, 6507 Ingelheim, De | |
US5500431A (en) * | 1993-04-14 | 1996-03-19 | Eli Lilly And Company | Tetrahydro-β-carbolines |
DE4343683A1 (de) * | 1993-12-21 | 1995-06-22 | Boehringer Ingelheim Kg | Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen |
-
1993
- 1993-12-21 DE DE4343683A patent/DE4343683A1/de not_active Ceased
-
1994
- 1994-12-14 RU RU96115153A patent/RU2136664C1/ru active
- 1994-12-14 DE DE59409461T patent/DE59409461D1/de not_active Expired - Fee Related
- 1994-12-14 JP JP7517154A patent/JPH09506882A/ja not_active Ceased
- 1994-12-14 AU AU12433/95A patent/AU699208B2/en not_active Ceased
- 1994-12-14 DK DK95903342T patent/DK0736011T3/da active
- 1994-12-14 PT PT95903342T patent/PT736011E/pt unknown
- 1994-12-14 PL PL94315054A patent/PL315054A1/xx unknown
- 1994-12-14 CA CA002178209A patent/CA2178209A1/en not_active Abandoned
- 1994-12-14 EP EP95903342A patent/EP0736011B1/de not_active Expired - Lifetime
- 1994-12-14 CN CN94194572A patent/CN1044905C/zh not_active Expired - Fee Related
- 1994-12-14 AT AT95903342T patent/ATE194978T1/de not_active IP Right Cessation
- 1994-12-14 ES ES95903342T patent/ES2149958T3/es not_active Expired - Lifetime
- 1994-12-14 WO PCT/EP1994/004150 patent/WO1995017389A1/de active IP Right Grant
- 1994-12-20 ZA ZA9410115A patent/ZA9410115B/xx unknown
- 1994-12-21 CO CO94057766A patent/CO4340626A1/es unknown
- 1994-12-21 US US08/360,867 patent/US5661157A/en not_active Expired - Fee Related
- 1994-12-28 TW TW083112295A patent/TW404941B/zh active
-
1997
- 1997-05-16 US US08/857,643 patent/US5968948A/en not_active Expired - Lifetime
-
1999
- 1999-06-10 US US09/329,443 patent/US6136819A/en not_active Expired - Fee Related
-
2000
- 2000-10-23 GR GR20000402346T patent/GR3034656T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT736011E (pt) | 2000-12-29 |
DE4343683A1 (de) | 1995-06-22 |
AU699208B2 (en) | 1998-11-26 |
DK0736011T3 (da) | 2000-11-13 |
ATE194978T1 (de) | 2000-08-15 |
CN1138325A (zh) | 1996-12-18 |
AU1243395A (en) | 1995-07-10 |
GR3034656T3 (en) | 2001-01-31 |
CN1044905C (zh) | 1999-09-01 |
RU2136664C1 (ru) | 1999-09-10 |
CO4340626A1 (es) | 1996-07-30 |
US5661157A (en) | 1997-08-26 |
US6136819A (en) | 2000-10-24 |
WO1995017389A1 (de) | 1995-06-29 |
JPH09506882A (ja) | 1997-07-08 |
DE59409461D1 (de) | 2000-08-31 |
EP0736011B1 (de) | 2000-07-26 |
CA2178209A1 (en) | 1995-06-29 |
ZA9410115B (en) | 1995-06-21 |
PL315054A1 (en) | 1996-09-30 |
US5968948A (en) | 1999-10-19 |
EP0736011A1 (de) | 1996-10-09 |
TW404941B (en) | 2000-09-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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