ES2149809T3 - Ensayo para los autoanticuerpos adrenales. - Google Patents

Ensayo para los autoanticuerpos adrenales.

Info

Publication number
ES2149809T3
ES2149809T3 ES93905501T ES93905501T ES2149809T3 ES 2149809 T3 ES2149809 T3 ES 2149809T3 ES 93905501 T ES93905501 T ES 93905501T ES 93905501 T ES93905501 T ES 93905501T ES 2149809 T3 ES2149809 T3 ES 2149809T3
Authority
ES
Spain
Prior art keywords
adrenal
protein
self
test
adrenal autoantibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93905501T
Other languages
English (en)
Inventor
Jadwiga Maria Furmaniak-Wehr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RSR Ltd
Original Assignee
RSR Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929205040A external-priority patent/GB9205040D0/en
Priority claimed from GB9216306A external-priority patent/GB2256046A/en
Application filed by RSR Ltd filed Critical RSR Ltd
Application granted granted Critical
Publication of ES2149809T3 publication Critical patent/ES2149809T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C12N9/0087—Steroid 21-monooxygenase (1.14.99.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/9901—Steroid 21-monooxygenase (1.14.99.10), i.e. steroid cytochrome P450 21-hydroxylase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Food Science & Technology (AREA)
  • Rehabilitation Therapy (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Manufacture, Treatment Of Glass Fibers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

AUTOANTIGENO ADRENAL SE AISLA Y SE CARACTERIZA COMO UNA PROTEINA OBTENIBLE DE FRACCION DE MICROSOMA DE LA GLANDULA ADRENAL, TENIENDO UN PESO MOLECULAR DE 50.000 A 60.000 Y ANTIGENICO HACIA AUTOANTICUERPO ADRENAL. LA FORMA INNATIVA, RECOMBINANTE O MODIFICADA DE LA PROTEINA, ASI COMO FRAGMENTOS DE LA MISMA, COMPRENDIENDO UN EPITOPE PARA AUTOANTICUERPO ADRENAL, SE USAN EN UN METODO Y EQUIPO PARA DETECTAR AUTOANTICUERPOS ADRENALES. LA PROTEINA ES TAMBIEN UTIL COMO MEDICAMENTO PARA TRATAR LA ENFERMEDAD DE ADDISSON. ESTUDIOS DE ABSORCION MUESTRAN QUE EL AUTOANTIGENO ES ESTEROIDE 21-HIDROXILASA.
ES93905501T 1992-03-07 1993-03-04 Ensayo para los autoanticuerpos adrenales. Expired - Lifetime ES2149809T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929205040A GB9205040D0 (en) 1992-03-07 1992-03-07 Adrenal autoantigen
GB9216306A GB2256046A (en) 1992-07-31 1992-07-31 Assay for adrenal autoantibodies useful in the diagnosis of addison's disease

Publications (1)

Publication Number Publication Date
ES2149809T3 true ES2149809T3 (es) 2000-11-16

Family

ID=26300465

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93905501T Expired - Lifetime ES2149809T3 (es) 1992-03-07 1993-03-04 Ensayo para los autoanticuerpos adrenales.

Country Status (7)

Country Link
EP (1) EP0629293B1 (es)
JP (1) JPH07504979A (es)
AT (1) ATE195023T1 (es)
CA (1) CA2131539A1 (es)
DE (1) DE69329109T2 (es)
ES (1) ES2149809T3 (es)
WO (1) WO1993018406A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT413768B (de) * 2003-07-29 2006-05-15 Herkner Kurt Dipl Ing Dr Techn Biochemisches diagnostikum zur erkennung rheumatoider arthritis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0340878B1 (en) * 1988-05-06 2001-05-16 Aventis Pharma S.A. Process for the biochemical oxidation of steroids and genetically engineered cells to be used therefor

Also Published As

Publication number Publication date
EP0629293B1 (en) 2000-07-26
CA2131539A1 (en) 1993-09-16
DE69329109T2 (de) 2001-03-22
DE69329109D1 (de) 2000-08-31
JPH07504979A (ja) 1995-06-01
EP0629293A1 (en) 1994-12-21
WO1993018406A1 (en) 1993-09-16
ATE195023T1 (de) 2000-08-15

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