ES2147646T3 - Composiciones para diagnostico, prevencion y tratamiento de la progresion de los tumores. - Google Patents
Composiciones para diagnostico, prevencion y tratamiento de la progresion de los tumores.Info
- Publication number
- ES2147646T3 ES2147646T3 ES96911511T ES96911511T ES2147646T3 ES 2147646 T3 ES2147646 T3 ES 2147646T3 ES 96911511 T ES96911511 T ES 96911511T ES 96911511 T ES96911511 T ES 96911511T ES 2147646 T3 ES2147646 T3 ES 2147646T3
- Authority
- ES
- Spain
- Prior art keywords
- progression
- diagnosis
- tumors
- prevention
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 230000001613 neoplastic effect Effects 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010061309 Neoplasm progression Diseases 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 208000037841 lung tumor Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000005751 tumor progression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1072—Differential gene expression library synthesis, e.g. subtracted libraries, differential screening
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A METODOS Y COMPOSICIONES PARA EL DIAGNOSTICO, PREVENCION Y TRATAMIENTO DE LA PROGRESION DE TUMORES EN CELULAS IMPLICADAS EN TUMORES HUMANOS TALES COMO MELANOMAS, DE PECHO, GASTROINTESTINALES, TUMORES PULMONARES Y ESTADOS DE NEOPLASIA TALES COMO LEUCEMIAS Y LINFOMAS. SE HAN IDENTIFICADO GENES QUE SE EXPRESAN DIFERENCIALMENTE EN CELULAS TUMORALES BENIGNAS (ESTO ES, NO MALIGNAS) RESPECTO A CELULAS TUMORALES MALIGNAS QUE EXHIBEN UN ELEVADO POTENCIAL METASTASICO. SE IDENTIFICAN ASIMISMO GENES A TRAVES DE LA CAPACIDAD DE SUS PRODUCTOS GENICOS IMPLICADOS EN LA PROGRESION A, Y/O EN LA AGRESIVIDAD DE, ESTADOS DE ENFERMEDAD POR TUMOR NEOPLASICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/412,431 US5633161A (en) | 1995-03-29 | 1995-03-29 | Murine gene fomy030 coding for tumor progression inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2147646T3 true ES2147646T3 (es) | 2000-09-16 |
Family
ID=23632952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96911511T Expired - Lifetime ES2147646T3 (es) | 1995-03-29 | 1996-03-29 | Composiciones para diagnostico, prevencion y tratamiento de la progresion de los tumores. |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US5633161A (es) |
| EP (3) | EP1006187B1 (es) |
| AT (2) | ATE190982T1 (es) |
| AU (1) | AU708746B2 (es) |
| CA (1) | CA2216717C (es) |
| DE (2) | DE69607332T2 (es) |
| DK (1) | DK0817792T3 (es) |
| ES (1) | ES2147646T3 (es) |
| GR (1) | GR3033478T3 (es) |
| PT (1) | PT817792E (es) |
| WO (1) | WO1996030389A1 (es) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633161A (en) * | 1995-03-29 | 1997-05-27 | Millennium Pharmaceuticals, Inc. | Murine gene fomy030 coding for tumor progression inhibitor |
| US6794185B1 (en) | 1995-03-29 | 2004-09-21 | Millennium Pharmaceuticals, Inc. | fohy030 nucleic acid molecules |
| US6251597B1 (en) | 1996-03-29 | 2001-06-26 | Millennium Pharmaceuticals, Inc. | Methods for detecting fohy030 |
| US6825320B1 (en) | 1995-03-29 | 2004-11-30 | Millenium Pharmaceuticals, Inc. | FOHY03 polypeptides |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| WO1997018454A2 (en) * | 1995-11-16 | 1997-05-22 | Baylor College Of Medicine | Method for identifying metastatic sequences |
| US5783182A (en) * | 1996-01-30 | 1998-07-21 | Baylor College Of Medicine | Method for identifying metastatic sequences |
| USRE38490E1 (en) | 1995-11-16 | 2004-04-06 | Baylor College Of Medicine | Method for identifying metastatic sequences |
| USRE38392E1 (en) | 1996-01-30 | 2004-01-20 | Baylor College Of Medicine | Method for identifying metastatic sequences |
| US6312909B1 (en) | 1996-03-29 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the diagnosis prevention and treatment of tumor progression |
| DE69635526T2 (de) * | 1996-07-31 | 2006-08-17 | Urocor, Inc., Oklahoma City | Biomarker und ziele für die diagnose, prognose und handhabung von prostatkrebs |
| CA2744096C (en) * | 1996-07-31 | 2013-07-30 | Laboratory Corporation Of America Holdings | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
| WO1998020143A1 (en) * | 1996-11-05 | 1998-05-14 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the lung |
| WO1998033926A1 (en) * | 1997-01-31 | 1998-08-06 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the lung |
| WO1998044133A1 (en) * | 1997-03-31 | 1998-10-08 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the gastrointestinal tract |
| US6194152B1 (en) | 1997-08-20 | 2001-02-27 | Dendreon Corporation | Prostate tumor polynucleotide compositions and methods of detection thereof |
| ZA989497B (en) * | 1997-10-20 | 2000-04-19 | Roche Diagnostics Gmbh | Positive-negative selection in homologous recombination. |
| CA2308565A1 (en) | 1997-11-05 | 1999-05-14 | Baylor College Of Medicine | Sequences for targeting metastatic cells |
| US8101349B2 (en) | 1997-12-23 | 2012-01-24 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells and their methods of use II |
| ID27813A (id) * | 1998-01-28 | 2001-04-26 | Corixa Corp | Senyawa-senyawa untuk terapi dan diagnosa kanker paru-paru dan metoda untuk penggunaannya |
| EP1062340A2 (en) | 1998-03-13 | 2000-12-27 | The Baylor College of Medicine | Compositions and methods for the treatment and prevention of metastatic disorders |
| EP1792988A3 (en) * | 1998-03-18 | 2007-08-22 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US7579160B2 (en) | 1998-03-18 | 2009-08-25 | Corixa Corporation | Methods for the detection of cervical cancer |
| WO1999047674A2 (en) * | 1998-03-18 | 1999-09-23 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US7258860B2 (en) | 1998-03-18 | 2007-08-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6482597B1 (en) | 1999-12-17 | 2002-11-19 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US6312695B1 (en) | 1998-03-18 | 2001-11-06 | Corixa Corporation | Compounds and methods for therapy of lung cancer |
| US6696247B2 (en) | 1998-03-18 | 2004-02-24 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US6426072B1 (en) | 2000-08-02 | 2002-07-30 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6706262B1 (en) | 1998-03-18 | 2004-03-16 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US6821518B1 (en) | 1998-03-18 | 2004-11-23 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US6960570B2 (en) | 1998-03-18 | 2005-11-01 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6531315B1 (en) | 1998-03-18 | 2003-03-11 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6518256B1 (en) | 1998-03-18 | 2003-02-11 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US7049063B2 (en) | 1998-03-18 | 2006-05-23 | Corixa Corporation | Methods for diagnosis of lung cancer |
| US6737514B1 (en) | 1998-12-22 | 2004-05-18 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6660838B1 (en) | 1998-03-18 | 2003-12-09 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US6324479B1 (en) * | 1998-05-08 | 2001-11-27 | Rosetta Impharmatics, Inc. | Methods of determining protein activity levels using gene expression profiles |
| US6218122B1 (en) * | 1998-06-19 | 2001-04-17 | Rosetta Inpharmatics, Inc. | Methods of monitoring disease states and therapies using gene expression profiles |
| US7258973B2 (en) * | 1998-08-31 | 2007-08-21 | Mayo Foundation For Medical Education & Research | Method for detecting a differentially expressed sequence |
| AU6263999A (en) * | 1998-09-28 | 2000-04-17 | Chiron Corporation | Human genes and gene expression products |
| ATE386804T1 (de) | 1998-10-15 | 2008-03-15 | Novartis Vaccines & Diagnostic | Gene mit veränderter expression in metastatischen brust- oder dickdarm- krebszellen |
| CA2356286C (en) * | 1998-12-23 | 2010-12-21 | University Of Sydney | An assay to detect a binding partner |
| US6156515A (en) * | 1999-02-09 | 2000-12-05 | Urocor, Inc. | Prostate-specific gene for diagnosis, prognosis and management of prostate cancer |
| AU3316600A (en) | 1999-02-22 | 2000-09-21 | Torben F. Orntoft | Gene expression in bladder tumors |
| FR2790960B1 (fr) * | 1999-03-15 | 2002-10-31 | Pf Medicament | Utilisation de fractions membranaires bacteriennes a activite immunostimulante dans le traitement de cancers, leurs procedes de preparation et les compositions pharmaceutiques les contenant |
| HK1049848A1 (zh) * | 1999-04-02 | 2003-05-30 | 科里克萨有限公司 | 用於治療和診斷肺癌的化合物和方法 |
| EP1173570A2 (en) * | 1999-04-23 | 2002-01-23 | Corixa Corporation | Compositions and methods for therapy and diagnosis of head/neck and lung squamous cell carcinoma |
| US20030045468A1 (en) * | 1999-05-28 | 2003-03-06 | Corixa Corporation | Compositions and methods for the therapy, diagnosis and monitoring of breast cancer |
| US6470277B1 (en) | 1999-07-30 | 2002-10-22 | Agy Therapeutics, Inc. | Techniques for facilitating identification of candidate genes |
| US6720173B1 (en) | 1999-11-08 | 2004-04-13 | Lexicon Genetics Incorporated | Human kinase protein and polynucleotides encoding the same |
| WO2001032870A1 (en) * | 1999-11-01 | 2001-05-10 | Lexicon Genetics Incorporated | Novel human melastatin-like proteins and polynucleotides encoding the same |
| EP1274463A2 (en) * | 1999-12-10 | 2003-01-15 | Whitehead Institute For Biomedical Research | Metastasis genes and uses thereof |
| CA2396127A1 (en) * | 1999-12-29 | 2001-07-12 | Torben F. Orntoft | Gene expression in biological conditions |
| EP1276879A4 (en) * | 2000-04-11 | 2004-12-22 | Univ Jefferson | MUIR-TORRE-LIKE SYNDROME IN Fhit-DEFECTIVE MICE |
| AU2001270478A1 (en) * | 2000-06-30 | 2002-01-14 | Aros Applied Biotechnology Aps | Gene expression in biological conditions |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| EP1184457A1 (en) * | 2000-09-05 | 2002-03-06 | Warner-Lambert Company | Identification of a capacitative calcium channel in antigen presenting cells and uses thereof |
| EP1186661A1 (en) * | 2000-09-05 | 2002-03-13 | Warner-Lambert Company | Identification of the major capacitative calcium channel in antigen presenting cells and uses thereof |
| DE60139705D1 (de) * | 2000-11-09 | 2009-10-08 | Sicel Technologies Inc | In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker |
| MXPA03004579A (es) * | 2000-11-28 | 2003-09-04 | Wyeth Corp | Analisis de expresion de acidos nucleicos del regulador de cromatina dependiente de actina y polipeptidos utiles en diagnostico y tratamiento del cancer de prostata. |
| EP2316976A1 (en) * | 2000-11-28 | 2011-05-04 | Wyeth LLC | Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| US7037652B2 (en) * | 2000-11-28 | 2006-05-02 | Wyeth | Expression analysis of KIAA nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
| BR0207297A (pt) | 2001-02-15 | 2005-04-19 | King Pharmaceuticals Inc | Composição farmacêutica em forma sólida e método de preparar uma forma de dosagem sólida de um ingrediente farmaceuticamente ativo |
| US6613534B2 (en) | 2001-03-20 | 2003-09-02 | Wake Forest University Health Sciences | MAP-2 as a determinant of metastatic potential |
| US7247426B2 (en) | 2001-08-02 | 2007-07-24 | Agilent Technologies, Inc. | Classifying cancers |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| US20050095588A1 (en) * | 2001-10-29 | 2005-05-05 | Kai Wang | Process for identifying membrane protein drug targets |
| US7557353B2 (en) * | 2001-11-30 | 2009-07-07 | Sicel Technologies, Inc. | Single-use external dosimeters for use in radiation therapies |
| US7133547B2 (en) * | 2002-01-24 | 2006-11-07 | Tripath Imaging, Inc. | Method for quantitative video-microscopy and associated system and computer software program product |
| US7462491B2 (en) * | 2002-01-31 | 2008-12-09 | Baylor College Of Medicine | Methods and compositions for diagnosis and monitoring of prostate cancer progression by detection of serum caveolin |
| US20030224464A1 (en) * | 2002-01-31 | 2003-12-04 | Baylor College Of Medicine | Secreted caveolin as a marker for prostate cancer |
| WO2004075032A2 (en) * | 2003-02-19 | 2004-09-02 | Sicel Technologies Inc. | In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes |
| EP2003196A3 (en) * | 2003-06-09 | 2009-01-07 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing cancer |
| US20050075543A1 (en) * | 2003-10-03 | 2005-04-07 | Calabrese Charles A. | Method of anonymous medical testing and providing the patient with the test results |
| US20050202407A1 (en) * | 2003-12-01 | 2005-09-15 | Baylor College Of Medicine | Methods and assays for screening anti-neoplastic therapeutic agents |
| WO2005074633A2 (en) * | 2004-02-03 | 2005-08-18 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
| EP1717320A1 (en) * | 2005-04-26 | 2006-11-02 | TopoTarget Germany AG | Identification of human gene sequences of cancer antigens expressed in metastatic carcinoma and involved in metastasis formation, and their use in cancer diagnosis, prognosis and therapy |
| US20070099209A1 (en) * | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| US7723112B2 (en) * | 2005-10-31 | 2010-05-25 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| PT2500360E (pt) | 2005-10-31 | 2015-10-15 | Oncomed Pharm Inc | Composições e métodos para diagnóstico e tratamento do cancro |
| WO2008092002A2 (en) * | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| US7669883B2 (en) * | 2007-03-29 | 2010-03-02 | Newfrey Llc | Air bag bracket/fastener |
| ES2663536T3 (es) | 2008-09-26 | 2018-04-13 | Oncomed Pharmaceuticals, Inc. | Agentes que se unen a receptores frizzled y usos de los mismos |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
| CN102971337B (zh) | 2010-04-01 | 2016-09-21 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
| HK1212216A1 (en) | 2012-10-23 | 2016-06-10 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
| JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路インヒビターによる処置の方法およびモニタリング |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| GB201520550D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520568D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd | Peptides |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0203970A1 (en) * | 1984-11-30 | 1986-12-10 | Whitehead Institute For Biomedical Research | Transmissible, mammalian genes associated with tumor metastasis |
| US5470970A (en) * | 1991-02-28 | 1995-11-28 | Dana-Farber Cancer Institute, Inc. | Maspin, a serpin with tumor suppresing activity |
| WO1992015602A1 (en) * | 1991-02-28 | 1992-09-17 | Dana-Farber Cancer Institute, Inc. | Cancer diagnosis and therapy |
| US5262321A (en) * | 1991-05-31 | 1993-11-16 | Dana-Farber Cancer Institute | DNA encoding p107 tumor suppressor |
| CA2072249C (en) * | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
| EP0583050A3 (en) | 1992-04-29 | 1994-10-05 | Amgen Inc | Stimulating factor of the recombinant "neu" receptor. |
| US5491064A (en) * | 1992-07-17 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | HTS-1 gene, a human tumor suppressor gene |
| US5496731A (en) * | 1993-03-25 | 1996-03-05 | Xu; Hong-Ji | Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy |
| US5457049A (en) * | 1993-08-12 | 1995-10-10 | Temple University - Of The Commonwealth System Of Higher Education | Tumor suppressor protein pRb2, related gene products, and DNA encoding therefor |
| JP3541966B2 (ja) * | 1994-08-03 | 2004-07-14 | 東洋紡績株式会社 | ポリベンザゾール繊維不織布の製造方法 |
| US6066322A (en) | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| US5633161A (en) * | 1995-03-29 | 1997-05-27 | Millennium Pharmaceuticals, Inc. | Murine gene fomy030 coding for tumor progression inhibitor |
| US5710137A (en) * | 1996-08-16 | 1998-01-20 | The Trustees Of Columbia University In The City Of New York | Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype |
-
1995
- 1995-03-29 US US08/412,431 patent/US5633161A/en not_active Expired - Lifetime
-
1996
- 1996-03-29 WO PCT/US1996/004413 patent/WO1996030389A1/en not_active Ceased
- 1996-03-29 EP EP99125829A patent/EP1006187B1/en not_active Expired - Lifetime
- 1996-03-29 AT AT96911511T patent/ATE190982T1/de not_active IP Right Cessation
- 1996-03-29 ES ES96911511T patent/ES2147646T3/es not_active Expired - Lifetime
- 1996-03-29 DE DE69607332T patent/DE69607332T2/de not_active Expired - Lifetime
- 1996-03-29 DE DE69630153T patent/DE69630153T2/de not_active Expired - Lifetime
- 1996-03-29 US US08/623,679 patent/US5674739A/en not_active Expired - Lifetime
- 1996-03-29 EP EP96911511A patent/EP0817792B1/en not_active Expired - Lifetime
- 1996-03-29 AT AT99125829T patent/ATE250624T1/de not_active IP Right Cessation
- 1996-03-29 PT PT96911511T patent/PT817792E/pt unknown
- 1996-03-29 CA CA2216717A patent/CA2216717C/en not_active Expired - Fee Related
- 1996-03-29 DK DK96911511T patent/DK0817792T3/da active
- 1996-03-29 EP EP03011132A patent/EP1344825A1/en not_active Withdrawn
- 1996-03-29 AU AU54378/96A patent/AU708746B2/en not_active Ceased
-
1997
- 1997-09-19 US US08/933,774 patent/US6025137A/en not_active Expired - Lifetime
-
1998
- 1998-10-01 US US09/164,671 patent/US6372896B1/en not_active Expired - Fee Related
-
2000
- 2000-05-22 GR GR20000401174T patent/GR3033478T3/el not_active IP Right Cessation
-
2004
- 2004-09-01 US US10/932,819 patent/US20050106600A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1006187A3 (en) | 2000-06-21 |
| AU5437896A (en) | 1996-10-16 |
| DE69607332T2 (de) | 2000-11-30 |
| EP1006187B1 (en) | 2003-09-24 |
| GR3033478T3 (en) | 2000-09-29 |
| US5674739A (en) | 1997-10-07 |
| EP0817792A1 (en) | 1998-01-14 |
| WO1996030389A1 (en) | 1996-10-03 |
| CA2216717A1 (en) | 1996-10-03 |
| EP0817792B1 (en) | 2000-03-22 |
| CA2216717C (en) | 2010-05-18 |
| US6372896B1 (en) | 2002-04-16 |
| PT817792E (pt) | 2000-08-31 |
| ATE250624T1 (de) | 2003-10-15 |
| EP1006187A2 (en) | 2000-06-07 |
| DK0817792T3 (da) | 2000-07-31 |
| US5633161A (en) | 1997-05-27 |
| DE69630153D1 (de) | 2003-10-30 |
| EP0817792A4 (en) | 1998-07-01 |
| DE69630153T2 (de) | 2004-06-09 |
| EP1344825A1 (en) | 2003-09-17 |
| US6025137A (en) | 2000-02-15 |
| DE69607332D1 (de) | 2000-04-27 |
| US20050106600A1 (en) | 2005-05-19 |
| AU708746B2 (en) | 1999-08-12 |
| ATE190982T1 (de) | 2000-04-15 |
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