ES2146944T3 - Procedimiento para la preparacion de 1-acil-4-arilpiperidinas. - Google Patents

Procedimiento para la preparacion de 1-acil-4-arilpiperidinas.

Info

Publication number
ES2146944T3
ES2146944T3 ES97116023T ES97116023T ES2146944T3 ES 2146944 T3 ES2146944 T3 ES 2146944T3 ES 97116023 T ES97116023 T ES 97116023T ES 97116023 T ES97116023 T ES 97116023T ES 2146944 T3 ES2146944 T3 ES 2146944T3
Authority
ES
Spain
Prior art keywords
formula
aryl
benzyloxy
acyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97116023T
Other languages
English (en)
Inventor
Walter Dr Brieden
Didier Loetscher
Andrew Dr Naughton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2146944T3 publication Critical patent/ES2146944T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LAS 1 DE R SUP,1} ES UN GRUPO ARILO OPCIONALMENTE SUSTITUIDO CON UNO O VARIOS GRUPOS ALQUILO C SUB,1-6}, GRUPOS ALCOXI C SUB,1-6}, GRUPOS BENCILOXI O GRUPOS TIOALQUILO C SUB,16}, Y/O UNO O VARIOS ATOMOS DE FLUOR Y R SUP,2} ES UN GRUPO ALQUILO C SUB,1-6}, UN GRUPO ALCOXI C SUB,1-6}, UN GRUPO ARILO OPCIONALMENTE SUSTITUIDO, UN GRUPO ARILAQUILO O UN GRUPO BENCILOXI OPCIONALMENTE SUSTITUIDO EN EL ANILLO FENILO, SE PRODUCEN POR REACCION DE UN HALOGENURO DE ARILMAGNESIO CON UN HALOGENURO DE 1 NIO OBTENIDO A PARTIR DE PIRIDINA Y UN HALOGENURO DE ACILO, EN PRESENCIA DE UN ACOPLADOR DE COBRE PARA DAR LA CORRESPONDIENTE 1 STERIOR. LAS 1 ERMEDIOS EN LA SINTESIS DE PRODUCTOS INTERMEDIOS EN LA SINTESIS DE SUSTANCIAS ACTIVAS FARMACEUTICAS, POR EJEMPLO, DE ANTAGONISTAS DE LOS RECEPTORES DE LA NEUROCININA.
ES97116023T 1996-09-18 1997-09-15 Procedimiento para la preparacion de 1-acil-4-arilpiperidinas. Expired - Lifetime ES2146944T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH228096 1996-09-18

Publications (1)

Publication Number Publication Date
ES2146944T3 true ES2146944T3 (es) 2000-08-16

Family

ID=4230084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97116023T Expired - Lifetime ES2146944T3 (es) 1996-09-18 1997-09-15 Procedimiento para la preparacion de 1-acil-4-arilpiperidinas.

Country Status (9)

Country Link
US (2) US5789596A (es)
EP (1) EP0831087B1 (es)
JP (1) JP4144048B2 (es)
AT (1) ATE194002T1 (es)
CA (1) CA2214288C (es)
DE (1) DE59701906D1 (es)
DK (1) DK0831087T3 (es)
ES (1) ES2146944T3 (es)
PT (1) PT831087E (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998488B2 (en) 2003-03-10 2006-02-14 Merck & Co., Inc. Process and intermediates for the preparation of 4-aryl piperidines
GB0308333D0 (en) * 2003-04-10 2003-05-14 Glaxo Group Ltd Novel compounds
US20060293298A1 (en) * 2003-04-10 2006-12-28 Bamford Mark J Compounds
DE102006061533A1 (de) * 2006-12-27 2008-07-03 Saltigo Gmbh Verfahren zur Herstellung von 2-Aminomethylpiperidin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8520154D0 (en) * 1985-08-10 1985-09-18 Beecham Group Plc Chemical process
DE4132808A1 (de) * 1991-10-02 1993-04-08 Hoechst Ag Verfahren zur herstellung von 2-aminomethylpiperidin
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles

Also Published As

Publication number Publication date
PT831087E (pt) 2000-10-31
DK0831087T3 (da) 2000-08-28
US5789596A (en) 1998-08-04
US5908935A (en) 1999-06-01
EP0831087A1 (de) 1998-03-25
ATE194002T1 (de) 2000-07-15
JP4144048B2 (ja) 2008-09-03
DE59701906D1 (de) 2000-07-27
CA2214288C (en) 2006-07-18
CA2214288A1 (en) 1998-03-18
JPH10114743A (ja) 1998-05-06
EP0831087B1 (de) 2000-06-21

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