ES2146788T3 - Genes suicida y asociaciones de analogos de nucleobases y nucleosidos de pirimidina con genes suicida para terapia de genes. - Google Patents

Genes suicida y asociaciones de analogos de nucleobases y nucleosidos de pirimidina con genes suicida para terapia de genes.

Info

Publication number
ES2146788T3
ES2146788T3 ES95940324T ES95940324T ES2146788T3 ES 2146788 T3 ES2146788 T3 ES 2146788T3 ES 95940324 T ES95940324 T ES 95940324T ES 95940324 T ES95940324 T ES 95940324T ES 2146788 T3 ES2146788 T3 ES 2146788T3
Authority
ES
Spain
Prior art keywords
genes
nucleobase
suicide genes
present
pirimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95940324T
Other languages
English (en)
Inventor
Gerard Tiraby
Jean-Paul Reynes
Michele Tiraby
Christophe Cazaux
Daniel Drocourt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cayla
Original Assignee
Cayla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cayla filed Critical Cayla
Application granted granted Critical
Publication of ES2146788T3 publication Critical patent/ES2146788T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C12N9/1211—Thymidine kinase (2.7.1.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02009—Uracil phosphoribosyltransferase (2.4.2.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01021—Thymidine kinase (2.7.1.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C12Y207/04009—Phosphotransferases with a phosphate group as acceptor (2.7.4) dTMP kinase (2.7.4.9)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE APLICA DOS GRUPOS DE GENES SUICIDA HIBRIDOS; LOS GENES DE UN GRUPO ACTIVAN ESPECIFICAMENTE LA 5FLUOROCITOSINA, ANALOGO DE NUCLEOBASE PIRIMIDICA Y LOS GENES DEL OTRO GRUPO ACTIVAN LA ACIDOTIMIDINA, ANALOGO DE NUCLEOBASE PIRIMIDICA EN DERIVADOS TOXICOS PARA LAS CELULAS DE MAMIFEROS. LA PRESENTE INVENCION SE APLICA TAMBIEN EN DIFERENTES METODOS PARA MATAR SELECTIVAMENTE CELULAS TUMORALES TRASFECTADAS O CELULAS INMUNES UTILIZANDO UN UNICO GEN SUICIDA HIBRIDO O UNA COMBINACION DE DOS GENES SUICIDAD HIBRIDOS ELEGIDOS POR SU COMPLEMENTARIEDAD EN SU ACCION ANTIMETABOLICA. LA PRESENTE INVENCION SE APLICA TAMBIEN EN VECTORES EUCARIOTAS QUE COMPRENDEN DOS UNIDADES DE EXPRESION DE GEN SUICIDA, LA PRIMER HACE A LAS CELULAS TUMORALES SENSIBLES A LA 5-FLUOROCITOSINA O AL 5FLUOROURACIL Y LA SEGUNDA HACE A LAS CELULAS INFECTADAS POR VIH RESISTENTES A LA ACIDOTIMIDINA DE MANERA SINERGICA.
ES95940324T 1994-11-17 1995-11-16 Genes suicida y asociaciones de analogos de nucleobases y nucleosidos de pirimidina con genes suicida para terapia de genes. Expired - Lifetime ES2146788T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/343,923 US5856153A (en) 1994-11-17 1994-11-17 Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases

Publications (1)

Publication Number Publication Date
ES2146788T3 true ES2146788T3 (es) 2000-08-16

Family

ID=23348272

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95940324T Expired - Lifetime ES2146788T3 (es) 1994-11-17 1995-11-16 Genes suicida y asociaciones de analogos de nucleobases y nucleosidos de pirimidina con genes suicida para terapia de genes.

Country Status (6)

Country Link
US (1) US5856153A (es)
EP (1) EP0792369B1 (es)
AU (1) AU4180996A (es)
DE (1) DE69516166T2 (es)
ES (1) ES2146788T3 (es)
WO (1) WO1996016183A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
FR2746016B1 (fr) * 1996-03-15 1998-04-17 Combinaisons d'enzymes pour la destruction de cellules proliferatives
FR2777570A1 (fr) * 1998-04-17 1999-10-22 Transgene Sa Mutant ayant une activite phosphoribosyl transferase
FR2794025A1 (fr) * 1999-05-25 2000-12-01 Transgene Sa Composition destinee a la mise en oeuvre d'un traitement antitumoral ou antiviral chez un mammifere
US6656917B1 (en) 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
DE19947668A1 (de) 1999-10-04 2001-04-19 Univ Eberhard Karls Tumorspezifischer Vektor für die Gentherapie
US20030214690A1 (en) * 2001-11-26 2003-11-20 Escuti Michael J. Holographic polymer photonic crystal
US7211570B2 (en) 2001-12-20 2007-05-01 Pharmasset, Inc. Treatment of EBV and KHSV infection
CA2474777A1 (en) * 2002-02-01 2003-08-07 Transgene S.A. Adenoviral vectors for modulating the cellular activities associated with pods
US7025970B2 (en) * 2002-03-15 2006-04-11 Baxter International Inc. Modified poxviruses, including modified smallpox virus vaccine based on recombinant drug-sensitive vaccinia virus, and new selection methods
US7127023B2 (en) * 2002-05-21 2006-10-24 Duke University Batch target and method for producing radionuclide
GB2390606A (en) * 2002-06-21 2004-01-14 Mohammad Saeid Hejazi Expression Plasmid
PL1649023T3 (pl) 2003-07-21 2009-01-30 Transgene Sa Polipeptyd o podwyższonej aktywności deaminazy cytozyny
CN101072792B (zh) * 2004-11-08 2012-09-26 特兰斯吉恩股份有限公司 设计用于在哺乳动物中进行抗肿瘤或抗病毒治疗的试剂盒
KR101022401B1 (ko) * 2005-09-29 2011-03-15 아주대학교산학협력단 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물
WO2012170490A2 (en) 2011-06-06 2012-12-13 Invivosciences, Llc Engineered cardiac tissues and methods of using them
DK3129037T3 (da) 2014-04-10 2020-02-03 Transgene Onkolytiske koppevirusvektorer
WO2016008976A1 (en) 2014-07-16 2016-01-21 Transgene Sa Oncolytic virus for expression of immune checkpoint modulators
CA3023022A1 (en) 2016-05-04 2017-11-09 Transgene Sa Combination therapy with cpg tlr9 ligand
WO2018091680A1 (en) 2016-11-18 2018-05-24 Transgene Sa Cowpox-based oncolytic vectors
WO2019020543A1 (en) 2017-07-28 2019-01-31 Transgene Sa ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS
MX2020009262A (es) 2018-03-07 2021-01-08 Transgene Vectores de parapoxvirus.
WO2020011754A1 (en) 2018-07-09 2020-01-16 Transgene Chimeric vaccinia viruses
CN114729324A (zh) 2019-07-24 2022-07-08 斯比根公司 永生化干细胞株的制备方法及其用途
WO2023213763A1 (en) 2022-05-02 2023-11-09 Transgene Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab
WO2023213764A1 (en) 2022-05-02 2023-11-09 Transgene Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf
TW202413636A (zh) 2022-08-18 2024-04-01 法商傳斯堅公司 嵌合痘病毒

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2569723B1 (fr) * 1984-08-31 1986-09-19 Centre Nat Rech Scient Application des antibiotiques de la famille des phleomycines a titre d'agent de selection dans le domaine du genie genetique
CA2018273C (en) * 1989-06-09 1999-04-06 Peter D. Senter Thermally stable cytosine deaminase
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies

Also Published As

Publication number Publication date
DE69516166D1 (de) 2000-05-11
WO1996016183A1 (fr) 1996-05-30
DE69516166T2 (de) 2000-11-16
EP0792369A1 (fr) 1997-09-03
US5856153A (en) 1999-01-05
AU4180996A (en) 1996-06-17
EP0792369B1 (fr) 2000-04-05

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