ES2146532B1 - ORGANIC COMPOUNDS PRODUCED BY MICROORGANISMS, IN PARTICULAR EXOPHIALA PISCIPHILA, AND ITS USE AS INHIBITORS OF THE INTERACTION OF CD28 AND ITS SPECIFIC RECEIVERS - Google Patents

ORGANIC COMPOUNDS PRODUCED BY MICROORGANISMS, IN PARTICULAR EXOPHIALA PISCIPHILA, AND ITS USE AS INHIBITORS OF THE INTERACTION OF CD28 AND ITS SPECIFIC RECEIVERS

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Publication number
ES2146532B1
ES2146532B1 ES9800277A ES9800277A ES2146532B1 ES 2146532 B1 ES2146532 B1 ES 2146532B1 ES 9800277 A ES9800277 A ES 9800277A ES 9800277 A ES9800277 A ES 9800277A ES 2146532 B1 ES2146532 B1 ES 2146532B1
Authority
ES
Spain
Prior art keywords
microorganisms
inhibitors
organic compounds
interaction
exophiala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9800277A
Other languages
Spanish (es)
Other versions
ES2146532A1 (en
Inventor
Monedero Emilio Diez
Steve W Elson
Los Frailes Alvarez Maite De
La Fuente Carralero Jesus De
Rodriguez Juan A Hueso
Puelles Jose Maria Sanchez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham SA
Original Assignee
SmithKline Beecham SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham SA filed Critical SmithKline Beecham SA
Priority to ES9800277A priority Critical patent/ES2146532B1/en
Priority to ES9901180A priority patent/ES2146556B1/en
Publication of ES2146532A1 publication Critical patent/ES2146532A1/en
Application granted granted Critical
Publication of ES2146532B1 publication Critical patent/ES2146532B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Compuestos orgánicos producidos por microorganismos, en particular exophiala pisciphila, y su uso como inhibidores de la interacción de CD28 y sus receptores específicos. La presente invención proporciona nuevos compuestos orgánicos que pueden obtenerse mediante el cultivo de microorganismos en particular cepas de hongos pertenecientes al género Exophiala u otros taxonómicamente relacionados. Estas sustancias son inhibidores de glicoproteínas, y particularmente de CD28, pudiendo actuar mediante la disrupción de las interacciones de CD28 con su receptor específico. La presente invención también proporciona procedimientos para la producción de las nuevas sustancias y otros metabolitos inhibidores de la glicoproteína o derivados de los mismos, que comprenden el cultivo de los microorganismos productores apropiados y el aislamiento de los metabolitos o sus derivados a partir de los cultivos.Organic compounds produced by microorganisms, in particular exophiala pisciphila, and their use as inhibitors of the interaction of CD28 and its specific receptors. The present invention provides new organic compounds that can be obtained by culturing microorganisms in particular fungal strains belonging to the genus Exophiala or other taxonomically related. These substances are inhibitors of glycoproteins, and particularly of CD28, being able to act by disrupting the interactions of CD28 with its specific receptor. The present invention also provides methods for the production of new substances and other glycoprotein inhibitor metabolites or derivatives thereof, which comprise the cultivation of the appropriate producing microorganisms and the isolation of the metabolites or their derivatives from the cultures.

ES9800277A 1998-02-12 1998-02-12 ORGANIC COMPOUNDS PRODUCED BY MICROORGANISMS, IN PARTICULAR EXOPHIALA PISCIPHILA, AND ITS USE AS INHIBITORS OF THE INTERACTION OF CD28 AND ITS SPECIFIC RECEIVERS Expired - Fee Related ES2146532B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES9800277A ES2146532B1 (en) 1998-02-12 1998-02-12 ORGANIC COMPOUNDS PRODUCED BY MICROORGANISMS, IN PARTICULAR EXOPHIALA PISCIPHILA, AND ITS USE AS INHIBITORS OF THE INTERACTION OF CD28 AND ITS SPECIFIC RECEIVERS
ES9901180A ES2146556B1 (en) 1998-02-12 1999-05-31 DERIVATIVES OF CARBOCYCLIC AROMATIC HYDROCARBONS PRODUCED BY HAPALOSPHAERIA DEFORMANS, INHIBITORS OF THE INTERACTION OF CD28 AND ITS SPECIFIC REACTORS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9800277A ES2146532B1 (en) 1998-02-12 1998-02-12 ORGANIC COMPOUNDS PRODUCED BY MICROORGANISMS, IN PARTICULAR EXOPHIALA PISCIPHILA, AND ITS USE AS INHIBITORS OF THE INTERACTION OF CD28 AND ITS SPECIFIC RECEIVERS

Publications (2)

Publication Number Publication Date
ES2146532A1 ES2146532A1 (en) 2000-08-01
ES2146532B1 true ES2146532B1 (en) 2001-02-01

Family

ID=8302724

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9800277A Expired - Fee Related ES2146532B1 (en) 1998-02-12 1998-02-12 ORGANIC COMPOUNDS PRODUCED BY MICROORGANISMS, IN PARTICULAR EXOPHIALA PISCIPHILA, AND ITS USE AS INHIBITORS OF THE INTERACTION OF CD28 AND ITS SPECIFIC RECEIVERS

Country Status (1)

Country Link
ES (1) ES2146532B1 (en)

Also Published As

Publication number Publication date
ES2146532A1 (en) 2000-08-01

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