ES2144357B1 - PROCEDURE FOR OBTAINING THE SOMATOSTATINA OCTREOTIDE ANALOG. - Google Patents
PROCEDURE FOR OBTAINING THE SOMATOSTATINA OCTREOTIDE ANALOG.Info
- Publication number
- ES2144357B1 ES2144357B1 ES009800162A ES9800162A ES2144357B1 ES 2144357 B1 ES2144357 B1 ES 2144357B1 ES 009800162 A ES009800162 A ES 009800162A ES 9800162 A ES9800162 A ES 9800162A ES 2144357 B1 ES2144357 B1 ES 2144357B1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- obtaining
- octreotide
- peptide
- trt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procedimiento para la obtención del análogo de somatostatina octreotide por medio de síntesis en fase sólida sobre soportes poliméricos y por intervención de grupos protectores del tipo Fmoc/tBu. Comprende construir el péptido lineal de 7 aminoácidos Boc-D-Phe-Cys(Trt)-Phe-D- Trp-Lys(Boc)Thr(tBu)-Cys(Trt)-Cl-tritil-R en donde R es un polímero; tratar con ácido la peptidil-resina resultante, para el desanclaje del péptido de la resina; ciclar la estructuras lineal obtenida por reacción con yodo antes o después de la incorporación en el extremo carboxi terminal del residuo de treoninol; incorporar el residuo de treoninol en solución sobre el péptido de 7 aminoácidos protegido con o sin el disulfuro formado; y desproteger las cadenas laterales con ácido para obtener octreotide.Procedure for obtaining the somatostatin octreotide analog by means of solid phase synthesis on polymeric supports and by intervention of protective groups of the Fmoc / tBu type. It comprises constructing the linear 7 amino acid peptide Boc-D-Phe-Cys (Trt) -Phe-D- Trp-Lys (Boc) Thr (tBu) -Cys (Trt) -Cl-trityl-R where R is a polymer ; acid treating the resulting peptidyl-resin, for de-anchoring the peptide from the resin; cycling the linear structures obtained by reaction with iodine before or after the incorporation in the carboxy terminal end of the threoninol residue; incorporate the threoninol residue in solution on the protected 7 amino acid peptide with or without the disulfide formed; and deprotecting the side chains with acid to obtain octreotide.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009800162A ES2144357B1 (en) | 1998-01-29 | 1998-01-29 | PROCEDURE FOR OBTAINING THE SOMATOSTATINA OCTREOTIDE ANALOG. |
ES99500012T ES2217717T3 (en) | 1998-01-29 | 1999-01-27 | PROCEDURE FOR OBTAINING THE OCTREOTIDE SOMATOSTATINE ANALOG. |
DE69915160T DE69915160T2 (en) | 1998-01-29 | 1999-01-27 | Process for the preparation of the somatostatin analog octreotide |
EP99500012A EP0953577B1 (en) | 1998-01-29 | 1999-01-27 | Procedure for obtaining the somatostatin analog, octreotide |
US09/240,145 US6346601B1 (en) | 1998-01-29 | 1999-01-29 | Procedure for obtaining the somatostatin analog, octreotide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009800162A ES2144357B1 (en) | 1998-01-29 | 1998-01-29 | PROCEDURE FOR OBTAINING THE SOMATOSTATINA OCTREOTIDE ANALOG. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2144357A1 ES2144357A1 (en) | 2000-06-01 |
ES2144357B1 true ES2144357B1 (en) | 2000-12-16 |
Family
ID=8302556
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009800162A Expired - Lifetime ES2144357B1 (en) | 1998-01-29 | 1998-01-29 | PROCEDURE FOR OBTAINING THE SOMATOSTATINA OCTREOTIDE ANALOG. |
ES99500012T Expired - Lifetime ES2217717T3 (en) | 1998-01-29 | 1999-01-27 | PROCEDURE FOR OBTAINING THE OCTREOTIDE SOMATOSTATINE ANALOG. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99500012T Expired - Lifetime ES2217717T3 (en) | 1998-01-29 | 1999-01-27 | PROCEDURE FOR OBTAINING THE OCTREOTIDE SOMATOSTATINE ANALOG. |
Country Status (4)
Country | Link |
---|---|
US (1) | US6346601B1 (en) |
EP (1) | EP0953577B1 (en) |
DE (1) | DE69915160T2 (en) |
ES (2) | ES2144357B1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6476186B1 (en) * | 2000-05-23 | 2002-11-05 | Institute Of Nuclear Energy Research | Process for preparing octreotide and derivatives thereof |
US7189856B2 (en) * | 2001-12-28 | 2007-03-13 | Gideon Shapiro | Non-peptide somatostatin receptor ligands |
DK1480998T3 (en) * | 2002-02-27 | 2007-03-26 | Ferring Bv | Intermediates and Methods for Preparing Heptapeptide Oxytocin Analogs |
US6987167B2 (en) | 2002-05-22 | 2006-01-17 | Wockhardt Limited | Process for production of the somatostatin analog, octreotide |
CN100338090C (en) * | 2002-12-17 | 2007-09-19 | 常州市第四制药厂有限公司 | Somatostatin full-synthesis method |
ES2237356T3 (en) * | 2003-04-07 | 2007-04-01 | Novetide Ltd. | PROCEDURE FOR THE PRODUCTION OF CYCLIC PEPTIDES. |
CA2458084A1 (en) * | 2004-03-12 | 2005-09-12 | Dalton Chemical Laboratories Inc. | Novel process for octreotide synthesis |
KR100998175B1 (en) | 2008-05-30 | 2010-12-03 | 애니젠 주식회사 | Process for the Preparation of Somatostatin |
TWI394585B (en) * | 2008-07-25 | 2013-05-01 | Iner Aec Executive Yuan | The magnetic fluid used for the development or treatment of peptides |
WO2010089757A2 (en) | 2008-11-07 | 2010-08-12 | Usv Limited | An improved process for synthesis of cyclic octapeptide |
US20140296144A1 (en) | 2011-09-30 | 2014-10-02 | Mylan Laboratories, Ltd. | Process for the preparation of octreotide acetate |
WO2013132505A1 (en) | 2012-03-09 | 2013-09-12 | Natco Pharma Limited | Improved process for preparation of octreotide by solution phase peptide synthesis |
CN112500450A (en) * | 2019-09-16 | 2021-03-16 | 翰宇药业(武汉)有限公司 | Synthetic method of octreotide |
CN112778400A (en) * | 2021-02-05 | 2021-05-11 | 合肥科生景肽生物科技有限公司 | Preparation method of octreotide |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE2512T1 (en) * | 1979-11-27 | 1983-03-15 | Sandoz Ag | POLYPEPTIDES, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE POLYPEPTIDES AND THEIR USE. |
EP0824103A1 (en) * | 1996-08-13 | 1998-02-18 | Chang-Shinn Su | Method for synthesis of Tyr-3-octreotide |
-
1998
- 1998-01-29 ES ES009800162A patent/ES2144357B1/en not_active Expired - Lifetime
-
1999
- 1999-01-27 EP EP99500012A patent/EP0953577B1/en not_active Expired - Lifetime
- 1999-01-27 ES ES99500012T patent/ES2217717T3/en not_active Expired - Lifetime
- 1999-01-27 DE DE69915160T patent/DE69915160T2/en not_active Expired - Lifetime
- 1999-01-29 US US09/240,145 patent/US6346601B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69915160D1 (en) | 2004-04-08 |
EP0953577B1 (en) | 2004-03-03 |
US6346601B1 (en) | 2002-02-12 |
DE69915160T2 (en) | 2005-01-20 |
ES2144357A1 (en) | 2000-06-01 |
ES2217717T3 (en) | 2004-11-01 |
EP0953577A1 (en) | 1999-11-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20000601 Kind code of ref document: A1 Effective date: 20000601 |
|
PC2A | Transfer of patent |
Owner name: BCN PEPTIDES, S.A. Effective date: 20120905 |