ES2144353B1 - NEW TACRINE ANALOGS: POTENTIAL NEUROPROTECTING AGENTS FOR ALZHEIMER AND PARKINSON DISEASES. YOUR OBTAINING PROCEDURE. - Google Patents

NEW TACRINE ANALOGS: POTENTIAL NEUROPROTECTING AGENTS FOR ALZHEIMER AND PARKINSON DISEASES. YOUR OBTAINING PROCEDURE.

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Publication number
ES2144353B1
ES2144353B1 ES9702701A ES9702701A ES2144353B1 ES 2144353 B1 ES2144353 B1 ES 2144353B1 ES 9702701 A ES9702701 A ES 9702701A ES 9702701 A ES9702701 A ES 9702701A ES 2144353 B1 ES2144353 B1 ES 2144353B1
Authority
ES
Spain
Prior art keywords
new
alzheimer
potential
parkinson
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9702701A
Other languages
Spanish (es)
Other versions
ES2144353A1 (en
Inventor
Contelles Jose Luis Marco
Grau M Angeles Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES9702701A priority Critical patent/ES2144353B1/en
Publication of ES2144353A1 publication Critical patent/ES2144353A1/en
Application granted granted Critical
Publication of ES2144353B1 publication Critical patent/ES2144353B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

Nuevos análogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. Su procedimiento de obtención. Esta invención describe una serio de nuevos análogos de tacrina, se describe por primera vez la síntesis de derivados de 4H-pirano[2,3-b]quinoleina, un nuevo sistema teterocíclico. Este protocolo se basa en la reacción de Friedlander entre 2-amino-3-ciano 4H-piranos polifuncionalizados y cicloalcanonas, en presencia de ácidos de Lewis. Es la primera vez que se describe en la literatura esta reacción con 4H-piranos polifuncionalizados. Los teterociclos finales 5-amino-4-aril-3-etoxicarbonil-2-metil-6,7,8,9-tetrahidro-4H-pirano[2,3-b] quinoleinas, se han obtenido, pues, en una sola etapa, con rendimiento en torno al 60%. Estos compuestos son potenciales nuevos agentes neuroprotectores para el tratamiento de las enfermedades de Alzheimer y Parkinson.New tacrine analogues: potential neuroprotective agents for Alzheimer's and Parkinson's diseases. Your procedure of obtaining. This invention describes a serious of new tacrine analogues, the synthesis of derivatives of 4H-pyrano [2,3-b] quinolein, a new teterocyclic system, is described for the first time. This protocol is based on Friedlander's reaction between polyfunctionalized 2-amino-3-cyano 4H-pyranos and cycloalcanones, in the presence of Lewis acids. It is the first time that this reaction with polyfunctionalized 4H-pyranos has been described in the literature. The final teterocycles 5-amino-4-aryl-3-ethoxycarbonyl-2-methyl-6,7,8,9-tetrahydro-4H-pyrano [2,3-b] quinoleins have thus been obtained in only one stage, with yield around 60%. These compounds are potential new neuroprotective agents for the treatment of Alzheimer's and Parkinson's diseases.

ES9702701A 1997-12-26 1997-12-26 NEW TACRINE ANALOGS: POTENTIAL NEUROPROTECTING AGENTS FOR ALZHEIMER AND PARKINSON DISEASES. YOUR OBTAINING PROCEDURE. Expired - Fee Related ES2144353B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9702701A ES2144353B1 (en) 1997-12-26 1997-12-26 NEW TACRINE ANALOGS: POTENTIAL NEUROPROTECTING AGENTS FOR ALZHEIMER AND PARKINSON DISEASES. YOUR OBTAINING PROCEDURE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9702701A ES2144353B1 (en) 1997-12-26 1997-12-26 NEW TACRINE ANALOGS: POTENTIAL NEUROPROTECTING AGENTS FOR ALZHEIMER AND PARKINSON DISEASES. YOUR OBTAINING PROCEDURE.

Publications (2)

Publication Number Publication Date
ES2144353A1 ES2144353A1 (en) 2000-06-01
ES2144353B1 true ES2144353B1 (en) 2001-01-01

Family

ID=8301636

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9702701A Expired - Fee Related ES2144353B1 (en) 1997-12-26 1997-12-26 NEW TACRINE ANALOGS: POTENTIAL NEUROPROTECTING AGENTS FOR ALZHEIMER AND PARKINSON DISEASES. YOUR OBTAINING PROCEDURE.

Country Status (1)

Country Link
ES (1) ES2144353B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2277741B1 (en) * 2005-05-25 2008-03-01 Ferrer Internacional, S.A. DERIVATIVES OF ACID 5-AMINO-1,4-DIHIDRO (1,8) NAFTIRIDIN 3-CARBOXILICO.
CN103145704A (en) * 2011-12-07 2013-06-12 江苏先声药业有限公司 1,4-dihydro-1,8-nalidixic acid derivatives, their pharmaceutical composition and use of the pharmaceutical composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE63903T1 (en) * 1984-10-25 1991-06-15 Hoechst Roussel Pharma 9-AMINO-1,2,3,4-TETRAHYDROACRIDIN-1-OL AND RELATED COMPOUNDS, PROCESSES FOR THEIR MANUFACTURE AND USE AS MEDICINAL PRODUCTS.
DK569087A (en) * 1986-10-31 1988-05-01 Sumitomo Pharma QUINOLINE DERIVATIVES, THEIR PREPARATION AND USE
FI91401C (en) * 1987-03-17 1994-06-27 Hoechst Roussel Pharma Process for the preparation of therapeutically active substituted 9-aminotetrahydroacrines and related compounds
US5210087A (en) * 1991-02-13 1993-05-11 Hoechst-Roussel Pharmaceuticals Inc. 9-aminotetrahydroacridines and related compounds

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Publication number Publication date
ES2144353A1 (en) 2000-06-01

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