ES2141795T3 - PREPARATION PROCEDURE FOR UREINS DERIVED FROM ALPHA, OMEGA-DIAMINOACIDOS. - Google Patents
PREPARATION PROCEDURE FOR UREINS DERIVED FROM ALPHA, OMEGA-DIAMINOACIDOS.Info
- Publication number
- ES2141795T3 ES2141795T3 ES94201643T ES94201643T ES2141795T3 ES 2141795 T3 ES2141795 T3 ES 2141795T3 ES 94201643 T ES94201643 T ES 94201643T ES 94201643 T ES94201643 T ES 94201643T ES 2141795 T3 ES2141795 T3 ES 2141795T3
- Authority
- ES
- Spain
- Prior art keywords
- omega
- alpha
- formula
- diaminoacidos
- ureins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1836—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from derivatives of carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
New cyclo-ureine terminated peptides and the corresponding cyclourein compounds. Cyclic ureins of formula (I) are new. A = 1-3C linear carbon chain optionally substituted by one or more 1-3C alkyl and functional groups containing O or S such as carboxyl, acyl, hydroxy, alkoxy or mercapto, but excluding 2-oxo-imidazolidine-4-carboxylic acid and (DL)-2-oxo-hexahydropyrimidine -4-carboxylic acid; Independent claims are included for: (1) peptides terminated by (I), of formula (II); and (2) N omega -(aminoacidocarbonyl)- alpha , omega -diaminoacids of formula (III). A1 = as A, but with 3C; A2 = as A, but with 4-8C; R3NH = amino acid or peptide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE9300621A BE1007183A3 (en) | 1993-06-18 | 1993-06-18 | Ureines DERIVED ALPHA, OMEGA-diamino AND METHOD FOR THEIR PREPARATION. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2141795T3 true ES2141795T3 (en) | 2000-04-01 |
Family
ID=3887112
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99103523T Expired - Lifetime ES2242315T3 (en) | 1993-06-18 | 1994-06-09 | UREINS DERIVED FROM ALPHA, OMEGA-DIAMINOACIDES AND PEPTIDES. |
ES94201643T Expired - Lifetime ES2141795T3 (en) | 1993-06-18 | 1994-06-09 | PREPARATION PROCEDURE FOR UREINS DERIVED FROM ALPHA, OMEGA-DIAMINOACIDOS. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99103523T Expired - Lifetime ES2242315T3 (en) | 1993-06-18 | 1994-06-09 | UREINS DERIVED FROM ALPHA, OMEGA-DIAMINOACIDES AND PEPTIDES. |
Country Status (11)
Country | Link |
---|---|
US (3) | US6060586A (en) |
EP (2) | EP0629612B1 (en) |
JP (1) | JP3800248B2 (en) |
AT (2) | ATE293598T1 (en) |
AU (1) | AU685794B2 (en) |
BE (1) | BE1007183A3 (en) |
CA (1) | CA2125638A1 (en) |
DE (2) | DE69434344T2 (en) |
ES (2) | ES2242315T3 (en) |
HU (1) | HU221844B1 (en) |
IL (1) | IL109978A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6160122A (en) * | 1996-06-28 | 2000-12-12 | Abbott Laboratories | Process for the preparation of a disubstituted thiazole |
US6961921B2 (en) * | 2001-09-06 | 2005-11-01 | Interdigital Technology Corporation | Pipeline architecture for maximum a posteriori (MAP) decoders |
WO2015030106A1 (en) * | 2013-09-02 | 2015-03-05 | 国立大学法人京都大学 | Compound having ggt inhibitory effect, and ggt-family enzyme inhibitor |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2288422A (en) * | 1938-11-11 | 1942-06-30 | Gen Aniline & Film Corp | Mixed ureas |
US2489233A (en) * | 1947-04-26 | 1949-11-22 | Hoffmann La Roche | Imidazolido-tetrahydrofurans |
US2650921A (en) * | 1948-03-23 | 1953-09-01 | Merck & Co Inc | 2-keto pyrimidines |
US2773872A (en) * | 1954-04-12 | 1956-12-11 | Merck & Co Inc | Dihydroorotic acid |
DE1963734A1 (en) * | 1969-12-19 | 1971-06-24 | Bayer Ag | Urea derivatives of acyl derivatives of the KTI |
DE2449167C2 (en) * | 1974-10-16 | 1984-05-24 | Grünenthal GmbH, 5190 Stolberg | N-acyl-L-histidyl-L-prolinamides, processes for their production and pharmaceutical preparations containing these compounds |
SE408300B (en) * | 1974-10-16 | 1979-06-05 | Gruenenthal Chemie | WAY TO PRODUCE NEW DIPEPTIDE DERIVATIVES |
JPS56147757A (en) | 1980-04-18 | 1981-11-16 | Ajinomoto Co Inc | Amino acid derivative |
DE3134933A1 (en) * | 1981-09-03 | 1983-03-31 | Hoechst Ag, 6230 Frankfurt | "UREA DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINES THEREOF AND THE USE THEREOF" |
DE3522938A1 (en) * | 1985-06-27 | 1987-01-08 | Bayer Ag | PERFORMANCE MEANS |
US5032577A (en) * | 1986-12-31 | 1991-07-16 | Abbott Laboratories | Peptidylaminodiols |
US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
US4980384A (en) | 1988-09-05 | 1990-12-25 | Shin-Etsu Chemical Co., Ltd. | Foamable silicone rubber composition and method for curing the same |
US5151497A (en) * | 1989-02-21 | 1992-09-29 | Japan Tobacco Inc. | Histidyl peptide derivatives |
DE3918057C1 (en) * | 1989-06-02 | 1990-05-03 | Degussa Ag, 6000 Frankfurt, De | |
EP0445239A4 (en) * | 1989-06-21 | 1992-03-25 | The Catholic University Of America | Anti-malarial composition and method of use |
US5312831A (en) * | 1993-05-12 | 1994-05-17 | American Cyanamid Company | Urethanes and ureas that induce cytokine production |
-
1993
- 1993-06-18 BE BE9300621A patent/BE1007183A3/en not_active IP Right Cessation
-
1994
- 1994-06-09 ES ES99103523T patent/ES2242315T3/en not_active Expired - Lifetime
- 1994-06-09 AT AT99103523T patent/ATE293598T1/en not_active IP Right Cessation
- 1994-06-09 EP EP94201643A patent/EP0629612B1/en not_active Expired - Lifetime
- 1994-06-09 EP EP99103523A patent/EP0922696B1/en not_active Expired - Lifetime
- 1994-06-09 AT AT94201643T patent/ATE187162T1/en not_active IP Right Cessation
- 1994-06-09 DE DE69434344T patent/DE69434344T2/en not_active Expired - Fee Related
- 1994-06-09 DE DE69421849T patent/DE69421849T2/en not_active Expired - Fee Related
- 1994-06-09 ES ES94201643T patent/ES2141795T3/en not_active Expired - Lifetime
- 1994-06-10 IL IL10997894A patent/IL109978A/en not_active IP Right Cessation
- 1994-06-10 CA CA002125638A patent/CA2125638A1/en not_active Abandoned
- 1994-06-17 AU AU64781/94A patent/AU685794B2/en not_active Ceased
- 1994-06-17 HU HU9401821A patent/HU221844B1/en not_active IP Right Cessation
- 1994-06-20 JP JP13711794A patent/JP3800248B2/en not_active Expired - Fee Related
-
1997
- 1997-06-17 US US08/985,658 patent/US6060586A/en not_active Expired - Fee Related
-
2000
- 2000-02-11 US US09/502,561 patent/US6310178B1/en not_active Expired - Fee Related
-
2001
- 2001-09-04 US US09/944,209 patent/US7030214B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0922696A3 (en) | 2003-01-22 |
DE69421849D1 (en) | 2000-01-05 |
HUT71414A (en) | 1995-11-28 |
EP0922696A2 (en) | 1999-06-16 |
EP0629612A1 (en) | 1994-12-21 |
US6060586A (en) | 2000-05-09 |
EP0629612B1 (en) | 1999-12-01 |
CA2125638A1 (en) | 1994-12-19 |
AU6478194A (en) | 1994-12-22 |
DE69421849T2 (en) | 2000-06-29 |
ES2242315T3 (en) | 2005-11-01 |
IL109978A (en) | 1999-10-28 |
BE1007183A3 (en) | 1995-04-18 |
HU9401821D0 (en) | 1994-09-28 |
US20020058784A1 (en) | 2002-05-16 |
US7030214B2 (en) | 2006-04-18 |
DE69434344D1 (en) | 2005-05-25 |
DE69434344T2 (en) | 2006-01-19 |
EP0922696B1 (en) | 2005-04-20 |
JPH0748356A (en) | 1995-02-21 |
ATE187162T1 (en) | 1999-12-15 |
AU685794B2 (en) | 1998-01-29 |
ATE293598T1 (en) | 2005-05-15 |
US6310178B1 (en) | 2001-10-30 |
HU221844B1 (en) | 2003-02-28 |
JP3800248B2 (en) | 2006-07-26 |
IL109978A0 (en) | 1994-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GC2A | Exploitation certificate registered application with search report |
Effective date: 19981028 |
|
FG2A | Definitive protection |
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