ES2139754T3 - 3-PHENYL-2-ISOXAZOLINES AS ANTI-INFLAMMATORY AGENTS. - Google Patents

3-PHENYL-2-ISOXAZOLINES AS ANTI-INFLAMMATORY AGENTS.

Info

Publication number
ES2139754T3
ES2139754T3 ES94927778T ES94927778T ES2139754T3 ES 2139754 T3 ES2139754 T3 ES 2139754T3 ES 94927778 T ES94927778 T ES 94927778T ES 94927778 T ES94927778 T ES 94927778T ES 2139754 T3 ES2139754 T3 ES 2139754T3
Authority
ES
Spain
Prior art keywords
isoxazolines
phenyl
inflammatory agents
dermatitis
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94927778T
Other languages
Spanish (es)
Inventor
Edward F Kleinman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2139754T3 publication Critical patent/ES2139754T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE 3-ARIL-2ISOXAZOLINAS QUE SON INHIBIDORES SELECTIVOS DE FOSFODIESTERASA TIPO IV (FFDIV). LAS 3-ARIL-2-ISOXAZOLINAS SON UTILES EN EL TRATAMIENTO DE SIDA, ASMA, ARTRITIS, BRONQUITIS, ENFERMEDADES CRONICAS DE OBSTRUCCION PULMONAR, PSORIASIS, RINITIS ALERGICA, DERMATITIS, SHOCK, DERMATITIS ATOPICA, ARTRITIS REUMATOIDE Y OSTEOARTRITIS. ESTA INVENCION TAMBIEN SE REFIERE A COMPOSICIONES FARMACEUTICAS UTILES PARA LO MISMO.THIS INVENTION REFERS TO 3-ARYL-2ISOXAZOLINE COMPOUNDS WHICH ARE SELECTIVE INHIBITORS OF TYPE IV PHOSPHODIESTERASE (FFDIV). 3-ARYL-2-ISOXAZOLINS ARE USEFUL IN THE TREATMENT OF AIDS, ASTHMA, ARTHRITIS, BRONCHITIS, CHRONIC DISEASES OF PULMONARY OBSTRUCTION, PSORIASIS, ALLERGIC RHINITIS, DERMATITIS, SHOCK, ATOPICA DERMATITIS, RHEUMARI AND OSTRUM THIS INVENTION ALSO REFERS TO USEFUL PHARMACEUTICAL COMPOSITIONS FOR THE SAME.

ES94927778T 1993-11-26 1994-10-12 3-PHENYL-2-ISOXAZOLINES AS ANTI-INFLAMMATORY AGENTS. Expired - Lifetime ES2139754T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15724193A 1993-11-26 1993-11-26

Publications (1)

Publication Number Publication Date
ES2139754T3 true ES2139754T3 (en) 2000-02-16

Family

ID=22562909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94927778T Expired - Lifetime ES2139754T3 (en) 1993-11-26 1994-10-12 3-PHENYL-2-ISOXAZOLINES AS ANTI-INFLAMMATORY AGENTS.

Country Status (12)

Country Link
US (1) US5686434A (en)
EP (1) EP0730587B1 (en)
JP (1) JP2818820B2 (en)
AT (1) ATE187447T1 (en)
CA (1) CA2177375A1 (en)
DE (1) DE69422061T2 (en)
DK (1) DK0730587T3 (en)
ES (1) ES2139754T3 (en)
FI (1) FI945556A7 (en)
GR (1) GR3032506T3 (en)
PT (1) PT730587E (en)
WO (1) WO1995014680A1 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3973697A (en) * 1996-08-21 1998-03-06 Pharmacia & Upjohn Company Isoxazoline derivatives useful as antimicrobials
DK0937075T3 (en) * 1996-11-11 2004-04-13 Altana Pharma Ag New imidazo and oxazolopyridines as phosphodiesterase inhibitors
US6124469A (en) * 1997-01-17 2000-09-26 Basf Aktiengesellschaft Process for preparing sulphurous 2-chloro-3-(4,5-dihydroisoxazol-3-yl)-benzoic acids
US6022977A (en) 1997-03-26 2000-02-08 Dupont Pharmaceuticals Company Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids
DE69902634T2 (en) * 1998-02-13 2003-04-24 Pharmacia & Upjohn Co., Kalamazoo SUBSTITUTED AMINOPHENYLISOXAZOLINE DERIVATIVES USED AS ANTIMICROBIAL AGENTS
DE19852095A1 (en) 1998-11-12 2000-05-18 Basf Ag Process for the preparation of 2-alkyl-3- (4,5-dihydroisoxazol-3-yl) acylbenzenes
EP1852424B1 (en) * 1998-05-11 2012-04-04 Basf Se Method for manufacturing isoxazoline-3-yL-acyl benzoles
WO2000021959A1 (en) * 1998-10-09 2000-04-20 Janssen Pharmaceutica N.V. 4,5-dihydro-isoxazole derivatives and their pharmaceutical use
CZ302882B6 (en) 1999-08-21 2012-01-04 Nycomed Gmbh Pharmaceutical composition
KR100399361B1 (en) 1999-11-04 2003-09-26 주식회사 엘지생명과학 Therapeutic composition comprising caspase inhibitor
CA2388564C (en) * 1999-09-17 2007-11-06 Lg Chem Investment Ltd. Caspase inhibitor
DE19953024A1 (en) * 1999-11-04 2001-05-10 Merck Patent Gmbh Isoxazole derivatives as phosphodiesterase VII inhibitors
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7153824B2 (en) 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
KR100594544B1 (en) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 Caspase inhibitors containing isoxazoline ring
AR045536A1 (en) 2003-08-29 2005-11-02 Ranbaxy Lab Ltd INHIBITORS OF PHOSPHODIESTERASE TYPE -IV
US20070259874A1 (en) * 2003-11-26 2007-11-08 Palle Venkata P Phosphodiesterase Inhibitors
BRPI0507818A (en) * 2004-03-26 2007-07-10 Cytokine Pharmasciences Inc compound and inhibition methods
EP1768966B1 (en) * 2004-06-17 2012-03-07 Infinity Discovery, Inc. Coumpounds and methods for inhibiting the interaction of bcl proteins with binding partners
ES2370788T3 (en) * 2005-02-07 2011-12-22 Aerocrine Ab CHECK BREATHED BREATH FLOW DURING ANALYSIS.
AU2006224777B2 (en) * 2005-03-15 2012-08-30 Ganial Immunotherapeutics Inc. Compounds having immunomodulator activity
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (en) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド Neurogenesis through modulation of muscarinic receptors
EP1928866A1 (en) 2005-09-05 2008-06-11 Ranbaxy Laboratories Limited Substituted indazoles as inhibitors of phosphodiesterase type-iv
EP1948167A1 (en) * 2005-10-19 2008-07-30 Ranbaxy Laboratories, Ltd. Compositions of phosphodiesterase type iv inhibitors
JP2009512711A (en) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Regulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008030651A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
CN101594878A (en) 2006-09-18 2009-12-02 雷普特药品公司 Treatment of liver disorders by administration of receptor-associated protein (RAP)-conjugates
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
JP2010504323A (en) * 2006-09-22 2010-02-12 ランバクシー ラボラトリーズ リミテッド Inhibitors of type IV phosphodiesterase
EP2066661A2 (en) * 2006-09-22 2009-06-10 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (en) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc USEFUL CYCLASS GUANILATE AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS.
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
PL3395372T3 (en) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Glutathione-based drug delivery system
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN102458374A (en) 2009-05-06 2012-05-16 实验室护肤股份有限公司 Skin delivery compositions comprising active agent-calcium phosphate particle complexes and methods of use thereof
CN101781294B (en) * 2010-03-10 2012-02-01 天津药物研究院 Imidazole derivative, and preparation method and application thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EA201391254A1 (en) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. METHOD FOR OBTAINING GUANYLATZCLAZE AGONISTS C
JP5968999B2 (en) 2011-03-31 2016-08-10 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 3-phenylisoxazoline-5-carboxamide and 3-phenylisoxazoline-5-thioamide active as herbicides and fungicides
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
IN2015DN01315A (en) * 2012-09-25 2015-07-03 Bayer Cropscience Ag
EA026931B9 (en) * 2012-09-25 2017-11-30 Байер Кропсайенс Аг Herbicidally and fungicidally active 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides or salts thereof
JP6499591B2 (en) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase receptor agonists for use in colon lavage
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists and uses thereof
CN105764916B (en) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 Ultrapure agonists of guanylate cyclase C, methods of making and using the same
EP3492106B1 (en) 2013-08-09 2021-02-17 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2018228986A1 (en) 2017-06-13 2018-12-20 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of tetrahydro and dihydrofuran carboxamides
SI3638665T1 (en) 2017-06-13 2021-11-30 Bayer Aktiengesellschaft Herbicidal 3-phenylisoxazoline-5-carboxamides tetrahydro and dihydrofuran carboxylic acids and esters
EP3668845B1 (en) 2017-08-17 2024-06-26 Bayer Aktiengesellschaft Herbicidally active 3-phenyl-5-trifluormethylisoxazolin-5-carboxamides of cyclopentyl carboxylic acids and esters
AU2019210916B2 (en) 2018-01-25 2023-03-02 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of cyclopentenyl carboxylic acid derivatives
AU2020238493B2 (en) 2019-03-12 2025-12-18 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of s-containing cyclopentenyl carboxylic acid esters
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
JPS62103070A (en) * 1985-10-29 1987-05-13 Mitsui Toatsu Chem Inc Isoxazoline derivative and plant growth regulator
US4912120A (en) * 1986-03-14 1990-03-27 Syntex (U.S.A.) Inc. 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors
WO1987006576A1 (en) * 1986-04-29 1987-11-05 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
ZA872997B (en) * 1986-05-09 1988-12-28 Warner Lambert Co Novel styryl pyrazoles,isoxazoles and analogs thereof having activity as 5-lipoxygenase inhibitors,pharmaceutical compositions and methods of use therefor
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
DE3736113A1 (en) * 1987-10-26 1989-05-03 Hoechst Ag DRUGS, PHOSPHORUS-BASED 2-ISOXAZOLINES AND ISOXAZOLES CONTAINING THEREOF, AND METHOD OF PREPARING THESE HETEROCYCLIC COMPOUNDS
US4952700A (en) * 1988-04-25 1990-08-28 W.R. Grace & Co.-Conn. Preparation of isoxazolines and isoxazoles
US4933464A (en) * 1988-04-25 1990-06-12 W. R. Grace & Co.-Conn. Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles
CA2017383A1 (en) * 1989-06-08 1990-12-08 Raymond R. Martodam Use of vanilloids for the treatment of respiratory diseases or disorders
WO1991007177A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
GB9007762D0 (en) * 1990-04-05 1990-06-06 Beecham Group Plc Novel compounds
EP0451790A1 (en) * 1990-04-12 1991-10-16 Hoechst Aktiengesellschaft 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use
DE4026018A1 (en) * 1990-08-17 1992-02-20 Hoechst Ag PLANT-PROTECTIVE AGENTS CONTAINING ISOXAZOLINE OR ISOTHIAZOLINE AND NEW ISOXAZOLINE AND ISOTHIAZOLINE
EP0557408A4 (en) * 1990-11-06 1993-10-27 Smith-Kline Beecham Corporation Imidazolidinone compounds
PT100441A (en) * 1991-05-02 1993-09-30 Smithkline Beecham Corp PIRROLIDINONES, ITS PREPARATION PROCESS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE
WO1993007141A1 (en) * 1991-10-11 1993-04-15 Smithkline Beecham Corporation Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production

Also Published As

Publication number Publication date
JP2818820B2 (en) 1998-10-30
DE69422061T2 (en) 2000-03-30
US5686434A (en) 1997-11-11
CA2177375A1 (en) 1995-06-01
JPH09500146A (en) 1997-01-07
DK0730587T3 (en) 2000-04-10
EP0730587A1 (en) 1996-09-11
FI945556A7 (en) 1995-05-27
GR3032506T3 (en) 2000-05-31
ATE187447T1 (en) 1999-12-15
WO1995014680A1 (en) 1995-06-01
PT730587E (en) 2000-05-31
DE69422061D1 (en) 2000-01-13
FI945556A0 (en) 1994-11-25
EP0730587B1 (en) 1999-12-08

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