ES2139754T3 - 3-PHENYL-2-ISOXAZOLINES AS ANTI-INFLAMMATORY AGENTS. - Google Patents

3-PHENYL-2-ISOXAZOLINES AS ANTI-INFLAMMATORY AGENTS.

Info

Publication number
ES2139754T3
ES2139754T3 ES94927778T ES94927778T ES2139754T3 ES 2139754 T3 ES2139754 T3 ES 2139754T3 ES 94927778 T ES94927778 T ES 94927778T ES 94927778 T ES94927778 T ES 94927778T ES 2139754 T3 ES2139754 T3 ES 2139754T3
Authority
ES
Spain
Prior art keywords
isoxazolines
phenyl
inflammatory agents
dermatitis
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94927778T
Other languages
Spanish (es)
Inventor
Edward F Kleinman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2139754T3 publication Critical patent/ES2139754T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE 3-ARIL-2ISOXAZOLINAS QUE SON INHIBIDORES SELECTIVOS DE FOSFODIESTERASA TIPO IV (FFDIV). LAS 3-ARIL-2-ISOXAZOLINAS SON UTILES EN EL TRATAMIENTO DE SIDA, ASMA, ARTRITIS, BRONQUITIS, ENFERMEDADES CRONICAS DE OBSTRUCCION PULMONAR, PSORIASIS, RINITIS ALERGICA, DERMATITIS, SHOCK, DERMATITIS ATOPICA, ARTRITIS REUMATOIDE Y OSTEOARTRITIS. ESTA INVENCION TAMBIEN SE REFIERE A COMPOSICIONES FARMACEUTICAS UTILES PARA LO MISMO.THIS INVENTION REFERS TO 3-ARYL-2ISOXAZOLINE COMPOUNDS WHICH ARE SELECTIVE INHIBITORS OF TYPE IV PHOSPHODIESTERASE (FFDIV). 3-ARYL-2-ISOXAZOLINS ARE USEFUL IN THE TREATMENT OF AIDS, ASTHMA, ARTHRITIS, BRONCHITIS, CHRONIC DISEASES OF PULMONARY OBSTRUCTION, PSORIASIS, ALLERGIC RHINITIS, DERMATITIS, SHOCK, ATOPICA DERMATITIS, RHEUMARI AND OSTRUM THIS INVENTION ALSO REFERS TO USEFUL PHARMACEUTICAL COMPOSITIONS FOR THE SAME.

ES94927778T 1993-11-26 1994-10-12 3-PHENYL-2-ISOXAZOLINES AS ANTI-INFLAMMATORY AGENTS. Expired - Lifetime ES2139754T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15724193A 1993-11-26 1993-11-26

Publications (1)

Publication Number Publication Date
ES2139754T3 true ES2139754T3 (en) 2000-02-16

Family

ID=22562909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94927778T Expired - Lifetime ES2139754T3 (en) 1993-11-26 1994-10-12 3-PHENYL-2-ISOXAZOLINES AS ANTI-INFLAMMATORY AGENTS.

Country Status (12)

Country Link
US (1) US5686434A (en)
EP (1) EP0730587B1 (en)
JP (1) JP2818820B2 (en)
AT (1) ATE187447T1 (en)
CA (1) CA2177375A1 (en)
DE (1) DE69422061T2 (en)
DK (1) DK0730587T3 (en)
ES (1) ES2139754T3 (en)
FI (1) FI945556A7 (en)
GR (1) GR3032506T3 (en)
PT (1) PT730587E (en)
WO (1) WO1995014680A1 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2186916T3 (en) * 1996-08-21 2003-05-16 Upjohn Co ISOXAZOLINE DERIVATIVES AS ANTIMICROBIAL AGENTS.
ES2213228T3 (en) * 1996-11-11 2004-08-16 Altana Pharma Ag NEW IMIDAZO- AND OXAZOLO-PIRIDINAS AS INHIBITING AGENTS OF PHOSPHODESTERASES.
JP2001508075A (en) * 1997-01-17 2001-06-19 ビーエーエスエフ アクチェンゲゼルシャフト Method for producing sulfur-containing 2-chloro-3- (4,5-dihydro-3-isoxazolyl) -benzoic acid
US6022977A (en) 1997-03-26 2000-02-08 Dupont Pharmaceuticals Company Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids
EP1054874B1 (en) * 1998-02-13 2002-08-28 PHARMACIA & UPJOHN COMPANY Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
DE19852095A1 (en) 1998-11-12 2000-05-18 Basf Ag Process for the preparation of 2-alkyl-3- (4,5-dihydroisoxazol-3-yl) acylbenzenes
EA009301B1 (en) * 1998-05-11 2007-12-28 Басф Акциенгезельшафт A process for preparing thioethers and use thereof
AU763460B2 (en) 1998-10-09 2003-07-24 Janssen Pharmaceutica N.V. 4,5-dihydro-isoxazole derivatives and their pharmaceutical use
SK287231B6 (en) 1999-08-21 2010-04-07 Nycomed Gmbh Medicament comprising a PDE inhibitor and a beta2 adrenoreceptor agonist
KR100399361B1 (en) 1999-11-04 2003-09-26 주식회사 엘지생명과학 Therapeutic composition comprising caspase inhibitor
JP4195561B2 (en) * 1999-09-17 2008-12-10 エルジー ケム インヴェストメント リミティッド Caspase inhibitor
DE19953024A1 (en) 1999-11-04 2001-05-10 Merck Patent Gmbh Isoxazole derivatives as phosphodiesterase VII inhibitors
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
AU2004226353A1 (en) 2003-04-01 2004-10-14 Laboratoires Serono Sa Inhibitors of phosphodiesterases in infertility
KR100594544B1 (en) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 Caspase inhibitors containing isoxazoline ring
US7825147B2 (en) 2003-08-29 2010-11-02 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-IV
WO2005051931A2 (en) * 2003-11-26 2005-06-09 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
AU2005228417A1 (en) * 2004-03-26 2005-10-13 Cytokine Pharmasciences, Inc. Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor
WO2006009869A1 (en) * 2004-06-17 2006-01-26 Infinity Pharmaceuticals, Inc. Coumpounds and methods for inhibiting the interaction of bcl proteins with binding partners
ES2370788T3 (en) * 2005-02-07 2011-12-22 Aerocrine Ab CHECK BREATHED BREATH FLOW DURING ANALYSIS.
US8304442B2 (en) * 2005-03-15 2012-11-06 Ganial Immunotherapeutics, Inc. Compounds having immunomodulator activity
JP2008539047A (en) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド Pharma Informatics System
EP2275096A3 (en) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenesis via modulation of the muscarinic receptors
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
WO2007029077A1 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Substituted indazoles as inhibitors of phosphodiesterase type-iv
WO2007045980A1 (en) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type iv inhibitors
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (en) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド GABA receptor-mediated regulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
KR20090064418A (en) * 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 Combination with 4-acylaminopyridine derivatives
KR20090071598A (en) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 Treatment of liver disease by administration of receptor binding protein (RAP) -conjugates
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2066661A2 (en) * 2006-09-22 2009-06-10 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
AU2007298549A1 (en) * 2006-09-22 2008-03-27 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-IV
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (en) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
PT2398500T (en) 2009-02-20 2019-06-14 2 Bbb Medicines B V Glutathione-based drug delivery system
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN102458374A (en) 2009-05-06 2012-05-16 实验室护肤股份有限公司 Skin delivery compositions comprising active agent-calcium phosphate particle complexes and methods of use thereof
CN101781294B (en) * 2010-03-10 2012-02-01 天津药物研究院 Imidazole derivative, and preparation method and application thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CA3100941C (en) 2011-03-01 2024-03-05 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
MX350825B (en) 2011-03-31 2017-09-22 Bayer Ip Gmbh Herbicidally and fungicidally active 3-phenylisoxazoline-5-carbox amides and 3-phenylisoxazoline-5-thioamides.
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
KR101977920B1 (en) * 2012-09-25 2019-05-13 바이엘 크롭사이언스 악티엔게젤샤프트 3-Phenylisoxazolin derivatives with herbicidal action
CN104797564B (en) 2012-09-25 2018-05-04 拜尔农作物科学股份公司 The 3- phenyl-isoxazole oxazoline -5- thioamides of the 3- phenyl-isoxazoles oxazoline -5- formamides and 5- epoxides of weeding and antifungal 5- epoxides-substituted-substituted
JP6499591B2 (en) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase receptor agonists for use in colon lavage
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
JP2016514671A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists and uses thereof
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
PT3638665T (en) 2017-06-13 2021-10-19 Bayer Cropscience Ag Herbicidally active 3-phenylisoxazoline-5-carboxamides of tetrahydro and dihydrofuran carboxylic acids and esters
CA3066872A1 (en) 2017-06-13 2018-12-20 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of tetrahydro and dihydrofuran carboxamides
EP3668845B1 (en) 2017-08-17 2024-06-26 Bayer Aktiengesellschaft Herbicidally active 3-phenyl-5-trifluormethylisoxazolin-5-carboxamides of cyclopentyl carboxylic acids and esters
ES2937924T3 (en) 2018-01-25 2023-04-03 Bayer Ag 3-Phenyl-isoxazole-yl-5-carboxamides of cyclopentenylcarboxylic acid derivatives with herbicidal activity
DK3937637T3 (en) 2019-03-12 2023-07-24 Bayer Ag HERBICIDELY ACTIVE 3-PHENYLISOXAZOLINE-5-CARBOXAMIDES OF S-CONTAINING CYCLOPENTENYLCARBONY ACID ESTERS
CN114340631A (en) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 Combination for reducing serum phosphate in a patient

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
JPS62103070A (en) * 1985-10-29 1987-05-13 Mitsui Toatsu Chem Inc Isoxazoline derivative and plant growth regulator
US4912120A (en) * 1986-03-14 1990-03-27 Syntex (U.S.A.) Inc. 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors
WO1987006576A1 (en) * 1986-04-29 1987-11-05 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
ZA872997B (en) * 1986-05-09 1988-12-28 Warner Lambert Co Novel styryl pyrazoles,isoxazoles and analogs thereof having activity as 5-lipoxygenase inhibitors,pharmaceutical compositions and methods of use therefor
DE3736113A1 (en) * 1987-10-26 1989-05-03 Hoechst Ag DRUGS, PHOSPHORUS-BASED 2-ISOXAZOLINES AND ISOXAZOLES CONTAINING THEREOF, AND METHOD OF PREPARING THESE HETEROCYCLIC COMPOUNDS
US4952700A (en) * 1988-04-25 1990-08-28 W.R. Grace & Co.-Conn. Preparation of isoxazolines and isoxazoles
US4933464A (en) * 1988-04-25 1990-06-12 W. R. Grace & Co.-Conn. Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles
CA2017383A1 (en) * 1989-06-08 1990-12-08 Raymond R. Martodam Use of vanilloids for the treatment of respiratory diseases or disorders
WO1991007177A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
GB9007762D0 (en) * 1990-04-05 1990-06-06 Beecham Group Plc Novel compounds
EP0451790A1 (en) * 1990-04-12 1991-10-16 Hoechst Aktiengesellschaft 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use
DE4026018A1 (en) * 1990-08-17 1992-02-20 Hoechst Ag PLANT-PROTECTIVE AGENTS CONTAINING ISOXAZOLINE OR ISOTHIAZOLINE AND NEW ISOXAZOLINE AND ISOTHIAZOLINE
IE913855A1 (en) * 1990-11-06 1992-05-22 Smithkline Beecham Corp Imidazolidinone compounds
PT100441A (en) * 1991-05-02 1993-09-30 Smithkline Beecham Corp PIRROLIDINONES, ITS PREPARATION PROCESS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE
WO1993007141A1 (en) * 1991-10-11 1993-04-15 Smithkline Beecham Corporation Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production

Also Published As

Publication number Publication date
DE69422061D1 (en) 2000-01-13
FI945556A0 (en) 1994-11-25
JPH09500146A (en) 1997-01-07
FI945556A7 (en) 1995-05-27
PT730587E (en) 2000-05-31
GR3032506T3 (en) 2000-05-31
EP0730587B1 (en) 1999-12-08
WO1995014680A1 (en) 1995-06-01
ATE187447T1 (en) 1999-12-15
US5686434A (en) 1997-11-11
DK0730587T3 (en) 2000-04-10
DE69422061T2 (en) 2000-03-30
JP2818820B2 (en) 1998-10-30
EP0730587A1 (en) 1996-09-11
CA2177375A1 (en) 1995-06-01

Similar Documents

Publication Publication Date Title
ES2139754T3 (en) 3-PHENYL-2-ISOXAZOLINES AS ANTI-INFLAMMATORY AGENTS.
ES2104424T3 (en) ISOXAZOLINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS.
ES2192192T3 (en) CATECOL DIETS AS SELECTIVE PDE INHIBITORS IV.
ES2154683T3 (en) INDOLES REPLACED AS TYPE IV PHOSPHODIESTERASE INHIBITORS.
CR8254A (en) [1,8] NAFTIDRIN-2-ONAS AND RELATED COMPOUNDS FOR THE TREATMENT OF CHICHOPHRENIA
BR0307564A (en) Nicotinamide derivatives useful as pde4 inhibitors
DK0988292T3 (en) Piperazine derivatives and their use as anti-inflammatory agents
GT200100022A (en) DERIVATIVES OF NICOTINAMIDE BENZOCONDENSADA-HETEROCICLILO USEFUL AS SELECTIVE INHIBITORS OF THE ISOZIMAS PDE4.
CR7043A (en) DERIVATIVES OF USEFUL ETERES AS INHIBITING GANETS OF THE ISOZIMAS PDE4
ES2111617T3 (en) CONDENSED PIRIMIDINE DERIVATIVES AND THEIR USE AS ANGIOTENSIN II ANTAGONISTS.
PA8543301A1 (en) DERIVATIVES OF DIHIDRO-BENZO (B) (1,4) DIAZEPIN-2 -ONA AS ANTAGONISTS II MGLUR2
ECSP045476A (en) THIAZOLIDINONES, ITS PREPARATION AND ITS USE AS MEDICATIONS
CR7038A (en) AMIDA DERIVATIVES OF TIAZOLILICO, OXAZOLILICO, PIRROLILICO AND IMIDIAZOLILICO ACIDS USED AS INHIBITORS OF THE ISOZIMAS PDE4
UY27976A1 (en) HETEROCYCLIC PIPERAZINES SUBSTITUTED FOR THE TREATMENT OF CHICHOPHRENIA
PA8446301A1 (en) 2-AMINO-6- (4-PHENOXI-2-SUBSTITUTED) -PIRIDINES SUBSTITUTED
MX9504422A (en) BICYCLE TETRAHYDROPIRAZOLOPYRIDINS.
UY27657A1 (en) USEFUL NICOTINAMIDE DERIVATIVES AS PDE4 INHIBITORS
HN2002000365A (en) LACTAMAS AS TAQUIQUININE ANTAGONISTS
CO5611124A2 (en) BENZOFURAN DERIVATIVES SUBSTITUTED USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS
ES2059320T3 (en) NEW DIARYL ALKANOIDS THAT HAVE ACTIVITY AS LIPOXIGENASE INHIBITORS.
BR0212661A (en) Substituted pyrazolyl benzenesulfamide compounds for the treatment of inflammation
HN2000000016A (en) 2-AMINOPIRIDINS CONTAINING SUBSTITUTES OF CONDENSED RING TYPE
ECSP003747A (en) METHOD AND COMPOSITIONS FOR THE TREATMENT OF PULMONARY DISEASES
CL2021001447A1 (en) Crystal forms a, b, d, i of 1–(6–((6–((1r)–1–hydroxyethyl)–8–isopropylamino)pyrido[3,4–d]pyrimidin–2–yl)amino)– 3-pyridyl)piperazin-2-one; pharmaceutical composition comprising them; and its use to treat rheumatoid arthritis, arteriosclerosis, among other diseases (divisional application 201901420).
CR7735A (en) HETEROCICLIC PIPERIZINES REPLACED FOR THE TREATMENT OF CHICHOPHRENIA

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 730587

Country of ref document: ES