ES2138536B1 - PROCEDURE FOR THE PREPARATION OF THE ANTIVIRAL COMPOUNDS PENCICLOVIR AND FAMCICLOVIR. - Google Patents
PROCEDURE FOR THE PREPARATION OF THE ANTIVIRAL COMPOUNDS PENCICLOVIR AND FAMCICLOVIR.Info
- Publication number
- ES2138536B1 ES2138536B1 ES9701614A ES9701614A ES2138536B1 ES 2138536 B1 ES2138536 B1 ES 2138536B1 ES 9701614 A ES9701614 A ES 9701614A ES 9701614 A ES9701614 A ES 9701614A ES 2138536 B1 ES2138536 B1 ES 2138536B1
- Authority
- ES
- Spain
- Prior art keywords
- penciclovir
- famciclovir
- procedure
- preparation
- side chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Procedimiento para la preparación de los compuestos antivirales penciclovir y famciclovir Un procedimiento para la preparación de: i) penciclovir o ii) famciclovir comprendiendo dicho procedimiento una o más de las siguientes etapas: a) formar una purina mediante el cierre del anillo de imidazol o pirimidina; b) hacer reaccionar una purina con un intermedio precursor de cadena lateral en posición 9 adecuado; c) convertir la cadena lateral en posición 9 en: i) 4-hidroxi-3-hidroximetilbut-l-ilo, o ii) 4-acetoxi-3-acetoximetilbut-l-ilo d) convertir una purina en: i) guanina, o ii) 2-aminopurina; caracterizado porque: la cadena lateral es como en el compuesto de fórmula (I): en la que R{sub,a , y R{sub,b son hidroxi o hidroxi protegido; que se convierte en la cadena lateral deseada por reducción usando un agente reductor suave.Procedure for the preparation of the antiviral compounds penciclovir and famciclovir A method for the preparation of: i) penciclovir or ii) famciclovir said procedure comprising one or more of the following steps: a) forming a purine by closing the imidazole or pyrimidine ring ; b) reacting a purine with a suitable 9-side chain precursor intermediate; c) converting the side chain in position 9 to: i) 4-hydroxy-3-hydroxymethylbut-l-yl, or ii) 4-acetoxy-3-acetoxymethylbut-l-yl d) converting a purine to: i) guanine, or ii) 2-aminopurine; characterized in that: the side chain is as in the compound of formula (I): wherein R {sub, a, and R {sub, b are hydroxy or protected hydroxy; which is converted to the desired side chain by reduction using a mild reducing agent.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9615275.6A GB9615275D0 (en) | 1996-07-20 | 1996-07-20 | Pharmaceuticals |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2138536A1 ES2138536A1 (en) | 2000-01-01 |
ES2138536B1 true ES2138536B1 (en) | 2000-11-16 |
Family
ID=10797240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9701614A Expired - Fee Related ES2138536B1 (en) | 1996-07-20 | 1997-07-18 | PROCEDURE FOR THE PREPARATION OF THE ANTIVIRAL COMPOUNDS PENCICLOVIR AND FAMCICLOVIR. |
Country Status (5)
Country | Link |
---|---|
AT (1) | AT412645B (en) |
ES (1) | ES2138536B1 (en) |
GB (1) | GB9615275D0 (en) |
GR (1) | GR1002943B (en) |
PT (1) | PT102028B (en) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3485225D1 (en) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | ANTIVIRAL GUANINE DERIVATIVES. |
SE8406538D0 (en) * | 1984-12-21 | 1984-12-21 | Astra Laekemedel Ab | NOVEL DERIVATIVES OF PURINE |
GB8817270D0 (en) * | 1988-07-20 | 1988-08-24 | Beecham Group Plc | Novel process |
GB8817607D0 (en) * | 1988-07-23 | 1988-09-01 | Beecham Group Plc | Novel process |
GB8822236D0 (en) * | 1988-09-21 | 1988-10-26 | Beecham Group Plc | Chemical process |
GB8922076D0 (en) * | 1989-09-28 | 1989-11-15 | Beecham Group Plc | Novel process |
JP3906488B2 (en) * | 1995-02-21 | 2007-04-18 | 味の素株式会社 | Method for producing purine derivatives |
-
1996
- 1996-07-20 GB GBGB9615275.6A patent/GB9615275D0/en active Pending
-
1997
- 1997-07-18 AT AT122597A patent/AT412645B/en not_active IP Right Cessation
- 1997-07-18 PT PT10202897A patent/PT102028B/en not_active IP Right Cessation
- 1997-07-18 GR GR970100282A patent/GR1002943B/en not_active IP Right Cessation
- 1997-07-18 ES ES9701614A patent/ES2138536B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT102028B (en) | 1999-04-30 |
ES2138536A1 (en) | 2000-01-01 |
AT412645B (en) | 2005-05-25 |
MX9705480A (en) | 1998-08-30 |
GB9615275D0 (en) | 1996-09-04 |
GR1002943B (en) | 1998-07-21 |
PT102028A (en) | 1998-01-30 |
ATA122597A (en) | 2004-10-15 |
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Legal Events
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EC2A | Search report published |
Date of ref document: 20000101 Kind code of ref document: A1 Effective date: 20000101 |
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FD2A | Announcement of lapse in spain |
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