ES2138536B1 - PROCEDURE FOR THE PREPARATION OF THE ANTIVIRAL COMPOUNDS PENCICLOVIR AND FAMCICLOVIR. - Google Patents

PROCEDURE FOR THE PREPARATION OF THE ANTIVIRAL COMPOUNDS PENCICLOVIR AND FAMCICLOVIR.

Info

Publication number
ES2138536B1
ES2138536B1 ES9701614A ES9701614A ES2138536B1 ES 2138536 B1 ES2138536 B1 ES 2138536B1 ES 9701614 A ES9701614 A ES 9701614A ES 9701614 A ES9701614 A ES 9701614A ES 2138536 B1 ES2138536 B1 ES 2138536B1
Authority
ES
Spain
Prior art keywords
penciclovir
famciclovir
procedure
preparation
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9701614A
Other languages
Spanish (es)
Other versions
ES2138536A1 (en
Inventor
Victor Witold Jacewicz
David Alan Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of ES2138536A1 publication Critical patent/ES2138536A1/en
Application granted granted Critical
Publication of ES2138536B1 publication Critical patent/ES2138536B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procedimiento para la preparación de los compuestos antivirales penciclovir y famciclovir Un procedimiento para la preparación de: i) penciclovir o ii) famciclovir comprendiendo dicho procedimiento una o más de las siguientes etapas: a) formar una purina mediante el cierre del anillo de imidazol o pirimidina; b) hacer reaccionar una purina con un intermedio precursor de cadena lateral en posición 9 adecuado; c) convertir la cadena lateral en posición 9 en: i) 4-hidroxi-3-hidroximetilbut-l-ilo, o ii) 4-acetoxi-3-acetoximetilbut-l-ilo d) convertir una purina en: i) guanina, o ii) 2-aminopurina; caracterizado porque: la cadena lateral es como en el compuesto de fórmula (I): en la que R{sub,a , y R{sub,b son hidroxi o hidroxi protegido; que se convierte en la cadena lateral deseada por reducción usando un agente reductor suave.Procedure for the preparation of the antiviral compounds penciclovir and famciclovir A method for the preparation of: i) penciclovir or ii) famciclovir said procedure comprising one or more of the following steps: a) forming a purine by closing the imidazole or pyrimidine ring ; b) reacting a purine with a suitable 9-side chain precursor intermediate; c) converting the side chain in position 9 to: i) 4-hydroxy-3-hydroxymethylbut-l-yl, or ii) 4-acetoxy-3-acetoxymethylbut-l-yl d) converting a purine to: i) guanine, or ii) 2-aminopurine; characterized in that: the side chain is as in the compound of formula (I): wherein R {sub, a, and R {sub, b are hydroxy or protected hydroxy; which is converted to the desired side chain by reduction using a mild reducing agent.

ES9701614A 1996-07-20 1997-07-18 PROCEDURE FOR THE PREPARATION OF THE ANTIVIRAL COMPOUNDS PENCICLOVIR AND FAMCICLOVIR. Expired - Fee Related ES2138536B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9615275.6A GB9615275D0 (en) 1996-07-20 1996-07-20 Pharmaceuticals

Publications (2)

Publication Number Publication Date
ES2138536A1 ES2138536A1 (en) 2000-01-01
ES2138536B1 true ES2138536B1 (en) 2000-11-16

Family

ID=10797240

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9701614A Expired - Fee Related ES2138536B1 (en) 1996-07-20 1997-07-18 PROCEDURE FOR THE PREPARATION OF THE ANTIVIRAL COMPOUNDS PENCICLOVIR AND FAMCICLOVIR.

Country Status (5)

Country Link
AT (1) AT412645B (en)
ES (1) ES2138536B1 (en)
GB (1) GB9615275D0 (en)
GR (1) GR1002943B (en)
PT (1) PT102028B (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (en) * 1983-08-18 1991-12-05 Beecham Group Plc ANTIVIRAL GUANINE DERIVATIVES.
SE8406538D0 (en) * 1984-12-21 1984-12-21 Astra Laekemedel Ab NOVEL DERIVATIVES OF PURINE
GB8817270D0 (en) * 1988-07-20 1988-08-24 Beecham Group Plc Novel process
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process
JP3906488B2 (en) * 1995-02-21 2007-04-18 味の素株式会社 Method for producing purine derivatives

Also Published As

Publication number Publication date
PT102028B (en) 1999-04-30
ES2138536A1 (en) 2000-01-01
AT412645B (en) 2005-05-25
MX9705480A (en) 1998-08-30
GB9615275D0 (en) 1996-09-04
GR1002943B (en) 1998-07-21
PT102028A (en) 1998-01-30
ATA122597A (en) 2004-10-15

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