ES2137942T3 - Estereoisomeros individuales de 7-(3-(aminoalquil)-1-pirrolidinil)-quinolonas y de naftiridonas utilizados como agentes antibacterianos. - Google Patents

Estereoisomeros individuales de 7-(3-(aminoalquil)-1-pirrolidinil)-quinolonas y de naftiridonas utilizados como agentes antibacterianos.

Info

Publication number
ES2137942T3
ES2137942T3 ES92901238T ES92901238T ES2137942T3 ES 2137942 T3 ES2137942 T3 ES 2137942T3 ES 92901238 T ES92901238 T ES 92901238T ES 92901238 T ES92901238 T ES 92901238T ES 2137942 T3 ES2137942 T3 ES 2137942T3
Authority
ES
Spain
Prior art keywords
aminoalkyl
antibacterial agents
quinolons
naphtiridones
pirrolidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901238T
Other languages
English (en)
Inventor
John Michael Domagala
John Steven Kiely
Mel Conrad Schroeder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2137942T3 publication Critical patent/ES2137942T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE DESCRIBEN ESTEREOISOMEROS INDIVIDUALES DE 7-[3-(1AMINOALQUIL)-1-PIRROLIDINIL]-QUINOLONAS Y NAFTIRIDONAS, SUS VENTAJAS TERAPEUTICAS COMO AGENTES ANTIBACTERIANOS, ASI COMO UN NUEVO METODO PARA LA PREPARACION Y SEPARACION DE TALES ESTEREOISOMEROS.
ES92901238T 1990-11-30 1991-11-12 Estereoisomeros individuales de 7-(3-(aminoalquil)-1-pirrolidinil)-quinolonas y de naftiridonas utilizados como agentes antibacterianos. Expired - Lifetime ES2137942T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62120190A 1990-11-30 1990-11-30
US73182591A 1991-07-15 1991-07-15
PCT/US1991/008419 WO1992009596A1 (en) 1990-11-30 1991-11-12 Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents

Publications (1)

Publication Number Publication Date
ES2137942T3 true ES2137942T3 (es) 2000-01-01

Family

ID=27088892

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92901238T Expired - Lifetime ES2137942T3 (es) 1990-11-30 1991-11-12 Estereoisomeros individuales de 7-(3-(aminoalquil)-1-pirrolidinil)-quinolonas y de naftiridonas utilizados como agentes antibacterianos.

Country Status (14)

Country Link
EP (2) EP0909759A3 (es)
JP (1) JPH06503565A (es)
AT (1) ATE181915T1 (es)
AU (2) AU658384B2 (es)
CA (1) CA2095338C (es)
DE (1) DE69131428T2 (es)
DK (1) DK0559774T3 (es)
ES (1) ES2137942T3 (es)
GR (1) GR3031224T3 (es)
IE (1) IE62205B1 (es)
MX (1) MX9102290A (es)
NZ (1) NZ240784A (es)
PT (1) PT99657B (es)
WO (1) WO1992009596A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU649893B1 (en) * 1991-11-25 1994-06-02 Warner-Lambert Company Antibacterial agents
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
AU716479B2 (en) * 1993-05-06 2000-02-24 Pharmacia & Upjohn Company Optically active 3-(1-(alkylamino) alkyl pyrrolidines
JPH08509979A (ja) * 1993-05-06 1996-10-22 ジ・アップジョン・カンパニー 光学活性な３−（１−（アルキルアミノ））アルキルピロリジン類
US6140510A (en) * 1993-05-06 2000-10-31 Pharmacia & Upjohn Company Optically active 3-(1-(carbamoyl))alkyl-2-oxo-pyrrolidines and optically active 3-(1-(alkylamido))alkyl-2-oxo-pyrrolidines
HUT77946A (hu) * 1994-11-18 1998-12-28 Pharmacia & Upjohn Co. Fluor-kinolon-származék fizikailag stabil, szilárd formája
NZ332719A (en) * 1996-05-10 2000-01-28 Upjohn Co Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases
US5929086A (en) 1996-05-10 1999-07-27 Pharmacia & Upjohn Company Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases
KR100395779B1 (ko) * 2001-05-25 2003-08-21 한국화학연구원 임의적으로 베타-위치가 치환된 알파-아릴알킬기의 제거를통해 3급 아미드 화합물로부터 2급 아미드 화합물을제조하는 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79189A (en) * 1985-06-26 1990-07-12 Daiichi Seiyaku Co Quinoline and/or naphthyridine-4-oxo-3-carboxylic acid derivatives,process for their preparation and pharmaceutical compositions comprising them
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
CA2012681A1 (en) * 1989-03-31 1990-09-30 Masayasu Okuhira Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same
US5157128A (en) * 1990-11-30 1992-10-20 Warner-Lambert Company Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates
KR950014567B1 (ko) * 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체

Also Published As

Publication number Publication date
DE69131428D1 (de) 1999-08-12
EP0559774A1 (en) 1993-09-15
ATE181915T1 (de) 1999-07-15
EP0909759A3 (en) 2000-04-26
CA2095338C (en) 2002-04-09
IE62205B1 (en) 1994-12-28
EP0559774B1 (en) 1999-07-07
PT99657B (pt) 1999-05-31
MX9102290A (es) 1992-07-08
GR3031224T3 (en) 1999-12-31
IE914160A1 (en) 1992-06-03
DK0559774T3 (da) 2000-01-31
WO1992009596A1 (en) 1992-06-11
EP0909759A2 (en) 1999-04-21
JPH06503565A (ja) 1994-04-21
PT99657A (pt) 1992-12-31
AU9057491A (en) 1992-06-25
CA2095338A1 (en) 1992-05-31
NZ240784A (en) 1997-06-24
AU658384B2 (en) 1995-04-13
AU2334495A (en) 1995-09-07
AU678715B2 (en) 1997-06-05
DE69131428T2 (de) 2000-01-05

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