ES2133401T3 - Utilizacion de farmacos cardiotonicos e inhibidores de sintesis del oxido nitrico para mitigar la hipotension patologica. - Google Patents
Utilizacion de farmacos cardiotonicos e inhibidores de sintesis del oxido nitrico para mitigar la hipotension patologica.Info
- Publication number
- ES2133401T3 ES2133401T3 ES93914126T ES93914126T ES2133401T3 ES 2133401 T3 ES2133401 T3 ES 2133401T3 ES 93914126 T ES93914126 T ES 93914126T ES 93914126 T ES93914126 T ES 93914126T ES 2133401 T3 ES2133401 T3 ES 2133401T3
- Authority
- ES
- Spain
- Prior art keywords
- nitric oxide
- pharmaces
- cardiotonic
- hypotension
- pathologic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 4
- 208000001953 Hypotension Diseases 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 230000036543 hypotension Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000003177 cardiotonic effect Effects 0.000 title 1
- 230000001575 pathological effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 abstract 1
- 101000959820 Homo sapiens Interferon alpha-1/13 Proteins 0.000 abstract 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract 1
- 108010002352 Interleukin-1 Proteins 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 230000008512 biological response Effects 0.000 abstract 1
- 229960001089 dobutamine Drugs 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
EL PRESENTE INVENTO SE REFIERE A UN METODO PARA LA PROFILAXIS O TRATAMIENTO DE UN ANIMAL CON HIPOTENSION SISTEMICA INDUCIDA POR UNA ENDOTOXINA Y/O UN MODIFICADOR DE RESPUESTA BIOLOGICA TAL COMO LAS CITOQUINAS, IFN, TFN, IL - 1 O IL - 2 Y SIMILARES. DICHO METODO IMPLICA ADMINISTRAR, PREFERIBLEMENTE INTRAVASCULARMENTE, UNA CANTIDAD EFECTIVA TERAPEUTICAMENTE DE DOBUTAMINA Y UN INHIBIDOR DE FORMACION DE OXIDO NITRICO DE ARGININA. AUNQUE ES PREFERIBLE QUE LA ADMINISTRACION SEA INTRAVASCULAR, SE CONTEMPLA QUE PUEDAN RESULTAR UTILES, POR EJEMPLO, OTRAS VIAS DE ADMINISTRACION PARENTERALES TALES COMO INTRAPERITONEAL, INTRAMUSCULAR O INYECCION SUBCUTANEA. LA ADMINISTRACION ENTERAL O TOPICA DE ANALOGOS DE ARGININA SE PUEDE MOSTRAR TAMBIEN BENEFICIOSA BAJO CIERTAS CONDICIONES CLINICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/890,430 US5312835A (en) | 1989-09-13 | 1992-05-29 | Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2133401T3 true ES2133401T3 (es) | 1999-09-16 |
Family
ID=25396669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93914126T Expired - Lifetime ES2133401T3 (es) | 1992-05-29 | 1993-05-25 | Utilizacion de farmacos cardiotonicos e inhibidores de sintesis del oxido nitrico para mitigar la hipotension patologica. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5312835A (es) |
EP (1) | EP0669824B1 (es) |
JP (1) | JPH08501069A (es) |
AT (1) | ATE178486T1 (es) |
AU (1) | AU664295B2 (es) |
CA (1) | CA2136205A1 (es) |
DE (1) | DE69324374T2 (es) |
ES (1) | ES2133401T3 (es) |
WO (1) | WO1993024122A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5312835A (en) * | 1989-09-13 | 1994-05-17 | Board Of Regents, The University Of Texas System | Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension |
US5612310A (en) * | 1993-05-24 | 1997-03-18 | Duke University | Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders |
US5554638A (en) * | 1993-05-24 | 1996-09-10 | Duke University | Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders |
US5695761A (en) * | 1993-12-23 | 1997-12-09 | Rutgers University | Suppression of nitric oxide production by osteopontin |
EP1067926A2 (en) * | 1998-04-06 | 2001-01-17 | Fujisawa Pharmaceutical Co., Ltd. | Immunosuppressive imidazole derivatives and their combination preparations with tacrolimus or cyclosporins |
GB9810299D0 (en) * | 1998-05-15 | 1998-07-15 | Glaxo Group Ltd | Use of nitric oxide synthase inhibitors |
WO2003099011A1 (en) * | 2002-05-28 | 2003-12-04 | Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Cardiac glycosides to treat cystic fibrosis and other il-8 dependent disorders |
CN100389768C (zh) * | 2004-08-25 | 2008-05-28 | 浙江震元制药有限公司 | 米力农注射用组合物及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1127322B (it) * | 1979-12-28 | 1986-05-21 | Italfarmaco Spa | Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici |
US5312835A (en) * | 1989-09-13 | 1994-05-17 | Board Of Regents, The University Of Texas System | Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension |
US5059712A (en) * | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
-
1992
- 1992-05-29 US US07/890,430 patent/US5312835A/en not_active Expired - Fee Related
-
1993
- 1993-05-25 AT AT93914126T patent/ATE178486T1/de not_active IP Right Cessation
- 1993-05-25 EP EP93914126A patent/EP0669824B1/en not_active Expired - Lifetime
- 1993-05-25 AU AU43897/93A patent/AU664295B2/en not_active Ceased
- 1993-05-25 CA CA002136205A patent/CA2136205A1/en not_active Abandoned
- 1993-05-25 WO PCT/US1993/004940 patent/WO1993024122A1/en active IP Right Grant
- 1993-05-25 ES ES93914126T patent/ES2133401T3/es not_active Expired - Lifetime
- 1993-05-25 JP JP6500705A patent/JPH08501069A/ja active Pending
- 1993-05-25 DE DE69324374T patent/DE69324374T2/de not_active Expired - Fee Related
-
1995
- 1995-03-31 US US08/338,591 patent/US5776979A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH08501069A (ja) | 1996-02-06 |
DE69324374T2 (de) | 1999-11-04 |
WO1993024122A1 (en) | 1993-12-09 |
DE69324374D1 (de) | 1999-05-12 |
EP0669824B1 (en) | 1999-04-07 |
CA2136205A1 (en) | 1993-12-09 |
EP0669824A4 (en) | 1995-07-25 |
ATE178486T1 (de) | 1999-04-15 |
AU4389793A (en) | 1993-12-30 |
EP0669824A1 (en) | 1995-09-06 |
US5312835A (en) | 1994-05-17 |
AU664295B2 (en) | 1995-11-09 |
US5776979A (en) | 1998-07-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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