ES2133095A1 - Acidos alquilidenglutaminicos con propiedades farmaceuticas. - Google Patents

Acidos alquilidenglutaminicos con propiedades farmaceuticas.

Info

Publication number
ES2133095A1
ES2133095A1 ES09700642A ES9700642A ES2133095A1 ES 2133095 A1 ES2133095 A1 ES 2133095A1 ES 09700642 A ES09700642 A ES 09700642A ES 9700642 A ES9700642 A ES 9700642A ES 2133095 A1 ES2133095 A1 ES 2133095A1
Authority
ES
Spain
Prior art keywords
optionally substituted
glutamic acid
alkyl
treatment
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09700642A
Other languages
English (en)
Other versions
ES2133095B1 (es
Inventor
Tercero Concepcion Pedregal
Esteban Almudena Rubio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly SA
Original Assignee
Lilly SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly SA filed Critical Lilly SA
Priority to ES009700642A priority Critical patent/ES2133095B1/es
Priority to JP10075357A priority patent/JPH10279542A/ja
Priority to CA002233077A priority patent/CA2233077A1/en
Priority to US09/046,445 priority patent/US5990165A/en
Priority to EP98302168A priority patent/EP0867430A3/en
Publication of ES2133095A1 publication Critical patent/ES2133095A1/es
Application granted granted Critical
Publication of ES2133095B1 publication Critical patent/ES2133095B1/es
Anticipated expiration legal-status Critical
Withdrawn - After Issue legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Acidos alquilidenglutámicos con propiedades farmacéuticas. Una composición farmacéutica de fórmula (I), en la que n es 1 ó 2, R sup,1 es -CO sub,2 H, R sub,2 es hidrógeno o alquilo C sub,1 -C sub,4 y R sub,3 es hidrógeno, alquilo C sub,1-10 , alquenilo C sub,2-10 , fenilo opcionalmente sustituido, fenil-alquilo C sub,1-4 opcionalmente sustituido, fenil alquenilo C sub,2-10 opcionalmente sustituido, (fenil opcionalmente sustituido) sub,2 -alquilo C sub,1-4 , cicloalquilo C sub,3-7 opcionalmente sustituido, cicloalquilo C sub,3-7 opcionalmente sustituido-alquilo C sub,1-4 o cicloalquilo C sub,3-7 opcionalmente sustituido-alquenilo C sub,2-10 o R sup,2 y R sup,3 juntos con el átomo de carbono al que están unidos, forman un grupo cicloalquilo C sub,4-7 opcionalmente sustituido; o una sal o un éster del mismo.
ES009700642A 1997-03-25 1997-03-25 Acidos alquilidenglutaminicos con propiedades farmaceuticas. Withdrawn - After Issue ES2133095B1 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES009700642A ES2133095B1 (es) 1997-03-25 1997-03-25 Acidos alquilidenglutaminicos con propiedades farmaceuticas.
JP10075357A JPH10279542A (ja) 1997-03-25 1998-03-24 製薬化合物
CA002233077A CA2233077A1 (en) 1997-03-25 1998-03-24 Pharmaceutical compounds
US09/046,445 US5990165A (en) 1997-03-25 1998-03-24 Pharmaceutical compounds
EP98302168A EP0867430A3 (en) 1997-03-25 1998-03-24 Glutamic acid derivatives and pharmaceutical compositions for the treatment of central nervous system disorders

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009700642A ES2133095B1 (es) 1997-03-25 1997-03-25 Acidos alquilidenglutaminicos con propiedades farmaceuticas.

Publications (2)

Publication Number Publication Date
ES2133095A1 true ES2133095A1 (es) 1999-08-16
ES2133095B1 ES2133095B1 (es) 2000-04-01

Family

ID=8298736

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009700642A Withdrawn - After Issue ES2133095B1 (es) 1997-03-25 1997-03-25 Acidos alquilidenglutaminicos con propiedades farmaceuticas.

Country Status (5)

Country Link
US (1) US5990165A (es)
EP (1) EP0867430A3 (es)
JP (1) JPH10279542A (es)
CA (1) CA2233077A1 (es)
ES (1) ES2133095B1 (es)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5343519B2 (es) * 1974-05-22 1978-11-20

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9324872D0 (en) * 1993-12-03 1994-01-19 Univ Pasteur Pharmaceutical compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5343519B2 (es) * 1974-05-22 1978-11-20

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chem. Abs. Vol. 90, no 23, 04.06.1979 (Columbus, Ohio, US), pagina 703, columna 1, resumen no 187333j, OGISHI, H. Glutamic acid derivatives, XP002068899 & JP 53043519 B (MITSUBISHI CHEMICAL INDUSTRIES CO., LTD) 20.11.1978 *
OUATHEK OUERFELLI et al. "Efficient synthesis of 4-methylene-L-glutamic acid and its analogues". Synlett, 1993, Junio. Paginas 409-410 *
TODESCHI, N. et al.: Conformational analysis by NMR spectroscopy and molecular simulation in water of methylated glutamic acids, agonists at glutamate receptors. J. of the Chemical Society, Perkin Transactions 1996, Vol. 2, paginas 1337-1351 *

Also Published As

Publication number Publication date
US5990165A (en) 1999-11-23
JPH10279542A (ja) 1998-10-20
EP0867430A2 (en) 1998-09-30
CA2233077A1 (en) 1998-09-25
ES2133095B1 (es) 2000-04-01
EP0867430A3 (en) 1998-12-09

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