ES2130992B1 - PROCEDURE FOR THE PREPARATION OF 1,4-DIHALOPHENACINES AND SYNTHESIS INTERMEDIATES. - Google Patents
PROCEDURE FOR THE PREPARATION OF 1,4-DIHALOPHENACINES AND SYNTHESIS INTERMEDIATES.Info
- Publication number
- ES2130992B1 ES2130992B1 ES9700906A ES9700906A ES2130992B1 ES 2130992 B1 ES2130992 B1 ES 2130992B1 ES 9700906 A ES9700906 A ES 9700906A ES 9700906 A ES9700906 A ES 9700906A ES 2130992 B1 ES2130992 B1 ES 2130992B1
- Authority
- ES
- Spain
- Prior art keywords
- sub
- synthesis intermediates
- procedure
- preparation
- dihalophenacines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento papa la preparación de 1,4-dihalofenacinas e intermedios de síntesis. Comprende hacer reaccionar 3,3,6,6-tetrahalo-1,2-ciclohexanodiona de fórmula (II), en donde X representa un grupo halo, con 1,2-diaminas aromáticas de fórmula (III), en donde R{sub,1 , R{sub,2 , R{sub,3 y R{sub,4 representan cualquier grupo orgánico o inorgánico, bajo condiciones de reacción adecuadas, y seguida de la bisdeshidrohalogenación para obtener el producto deseado. También se refiere a intermedios de síntesis 1,1,4,4-tetrahalo-1,2,3,4-tetrahidrofenacinas (IV), útiles para la obtención de dichas 1,4-dihalofenacinas (I). Tienen aplicación por su actividad herbicida, por un lado, y actividad antibiótico o antitumoral, por otro.Procedure for the preparation of 1,4-dihalofenacins and synthesis intermediates. It comprises reacting 3,3,6,6-tetrahalo-1,2-cyclohexanedione of formula (II), where X represents a halo group, with aromatic 1,2-diamines of formula (III), where R {sub , 1, R {sub, 2, R {sub, 3 and R {sub, 4 represent any organic or inorganic group, under suitable reaction conditions, and followed by bishydrohalogenation to obtain the desired product. It also refers to 1,1,4,4-tetrahalo-1,2,3,4-tetrahydrophenazines (IV) synthesis intermediates, useful for obtaining said 1,4-dihalophenazines (I). They have application due to their herbicidal activity, on the one hand, and antibiotic or antitumor activity, on the other.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700906A ES2130992B1 (en) | 1997-04-21 | 1997-04-21 | PROCEDURE FOR THE PREPARATION OF 1,4-DIHALOPHENACINES AND SYNTHESIS INTERMEDIATES. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700906A ES2130992B1 (en) | 1997-04-21 | 1997-04-21 | PROCEDURE FOR THE PREPARATION OF 1,4-DIHALOPHENACINES AND SYNTHESIS INTERMEDIATES. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2130992A1 ES2130992A1 (en) | 1999-07-01 |
ES2130992B1 true ES2130992B1 (en) | 2000-03-01 |
Family
ID=8299109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9700906A Expired - Fee Related ES2130992B1 (en) | 1997-04-21 | 1997-04-21 | PROCEDURE FOR THE PREPARATION OF 1,4-DIHALOPHENACINES AND SYNTHESIS INTERMEDIATES. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2130992B1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012088438A1 (en) | 2010-12-22 | 2012-06-28 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
-
1997
- 1997-04-21 ES ES9700906A patent/ES2130992B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2130992A1 (en) | 1999-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990701 Kind code of ref document: A1 Effective date: 19990701 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20170728 |