ES2130992A1 - Process for the preparation of 1,4-dihalophenacins and synthesis intermediates - Google Patents
Process for the preparation of 1,4-dihalophenacins and synthesis intermediatesInfo
- Publication number
- ES2130992A1 ES2130992A1 ES09700906A ES9700906A ES2130992A1 ES 2130992 A1 ES2130992 A1 ES 2130992A1 ES 09700906 A ES09700906 A ES 09700906A ES 9700906 A ES9700906 A ES 9700906A ES 2130992 A1 ES2130992 A1 ES 2130992A1
- Authority
- ES
- Spain
- Prior art keywords
- dihalophenacins
- synthesis intermediates
- preparation
- tetrahalo
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Process for the preparation of 1,4-dihalophenacins and synthesis intermediates. Comprises reacting 3,3,6,6-tetrahalo-1,2-cyclohexanedione of formula II where X represents a halogen group with aromatic 1,2-diamines of formula III where R1, R2, R3 and R4 represent any organic or inorganic group under suitable reaction conditions and followed by bisdehydrohalogenation in order to obtain the desired product. Also relates to synthesis intermediates 1,1, 4,4- tetrahalo-1,2,3,4-tetrahydrophenacins IV which are useful for obtaining the said 1,4-dihalophenacins I. Has application on account of its herbicidal activity on the one hand and its antibiotic or antitumoral activity on the other. <IMAGE>
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700906A ES2130992B1 (en) | 1997-04-21 | 1997-04-21 | PROCEDURE FOR THE PREPARATION OF 1,4-DIHALOPHENACINES AND SYNTHESIS INTERMEDIATES. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700906A ES2130992B1 (en) | 1997-04-21 | 1997-04-21 | PROCEDURE FOR THE PREPARATION OF 1,4-DIHALOPHENACINES AND SYNTHESIS INTERMEDIATES. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2130992A1 true ES2130992A1 (en) | 1999-07-01 |
ES2130992B1 ES2130992B1 (en) | 2000-03-01 |
Family
ID=8299109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9700906A Expired - Fee Related ES2130992B1 (en) | 1997-04-21 | 1997-04-21 | PROCEDURE FOR THE PREPARATION OF 1,4-DIHALOPHENACINES AND SYNTHESIS INTERMEDIATES. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2130992B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012088438A1 (en) | 2010-12-22 | 2012-06-28 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
-
1997
- 1997-04-21 ES ES9700906A patent/ES2130992B1/en not_active Expired - Fee Related
Non-Patent Citations (3)
Title |
---|
CROSS, B et al. Synthesis of pesticidal evaluation of phenazines I. Halophenazines, J. Sci. Food. Agric., 1969, Vol. 20, paginas 8-12 * |
MAFFEI, S et al. Alogenazione della fenazine. Clorurazione in acido cloridrico. Gazz. Chim. Ital., 1953, Vol. 83, paginas 327-334 * |
TADA, M. The synthesis of Methylthio- and bis(methylthio)phenazine Derivatives. Bulletin of the Chemical Society of Japan, 1974, Vol. 47, No 7, paginas 1803-1804 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012088438A1 (en) | 2010-12-22 | 2012-06-28 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
EP2655334A1 (en) * | 2010-12-22 | 2013-10-30 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
EP2655334A4 (en) * | 2010-12-22 | 2014-12-31 | Eutropics Pharmaceuticals Inc | Compositions and methods useful for treating diseases |
US9351971B2 (en) | 2010-12-22 | 2016-05-31 | Eutropics Pharmaceuticals, Inc. | Substituted 2,2′-biphenazines for treating diseases |
Also Published As
Publication number | Publication date |
---|---|
ES2130992B1 (en) | 2000-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990701 Kind code of ref document: A1 Effective date: 19990701 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20170728 |