ES2129370A1 - Procedimiento para la obtencion del 2-(4-(4-(m-etilsulfonamidofenil)p iperazin-1-il(butil)-1,3-dioxoperhidropirrolo)1,2-c(imidazol - Google Patents
Procedimiento para la obtencion del 2-(4-(4-(m-etilsulfonamidofenil)p iperazin-1-il(butil)-1,3-dioxoperhidropirrolo)1,2-c(imidazolInfo
- Publication number
- ES2129370A1 ES2129370A1 ES09701987A ES9701987A ES2129370A1 ES 2129370 A1 ES2129370 A1 ES 2129370A1 ES 09701987 A ES09701987 A ES 09701987A ES 9701987 A ES9701987 A ES 9701987A ES 2129370 A1 ES2129370 A1 ES 2129370A1
- Authority
- ES
- Spain
- Prior art keywords
- imidazol
- piperazine
- butyl
- dioxoperhydroyrrolo
- ethylsulfonamido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento para la obtención del 2-[4-[4-(m-etilsulfonamido-Fenil)piperazin-1-il]butil]-1,3-dioxoperhidropirrolo[1,2-c]imidazol. La presente invención tiene por objeto un nuevo procedimiento de obtención del 2-[4-[4-(m-etilsulfonamidofenil)piperazin-1-il]butil]-1,3-dioxoperhidropirrolo[1,2-c]imidazol (1, EF-7412), compuesto de síntesis con interés terapéutico por su carácter antagonista del receptor 5-HT{sub,1A . Este nuevo procedimiento obvia las dificultades del método descrito previamente para su preparación ya que llega al producto deseado en una secuencia sintética de mayor simplicidad y con rendimientos superiores.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9701987A ES2129370B1 (es) | 1997-09-23 | 1997-09-23 | Procedimiento para la obtencion del 2-(4-(4-(m-etilsulfonamidofenil)p iperazin-1-il(butil)-1,3-dioxoperhidropirrolo)1,2-c(imidazol |
PCT/ES1998/000250 WO1999015527A1 (es) | 1997-09-23 | 1998-09-15 | PROCEDIMIENTO PARA LA OBTENCION DEL 2-[4-[4-(m- ETILSULFONAMIDOFENIL) PIPERAZIN-1-IL] BUTIL]-1,3- DIOXOPERHIDROPIRROLO [1,2-c]IMIDAZOL |
AU90730/98A AU9073098A (en) | 1997-09-23 | 1998-09-15 | Process for obtaining 2-(4-(4-(m- ethylsulfonamido-phenyl) piperazine-1-yl) butyl)-1,3- dioxoperhydroyrrolo (1,2-c)imidazol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9701987A ES2129370B1 (es) | 1997-09-23 | 1997-09-23 | Procedimiento para la obtencion del 2-(4-(4-(m-etilsulfonamidofenil)p iperazin-1-il(butil)-1,3-dioxoperhidropirrolo)1,2-c(imidazol |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2129370A1 true ES2129370A1 (es) | 1999-06-01 |
ES2129370B1 ES2129370B1 (es) | 2000-03-01 |
Family
ID=8300663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9701987A Expired - Fee Related ES2129370B1 (es) | 1997-09-23 | 1997-09-23 | Procedimiento para la obtencion del 2-(4-(4-(m-etilsulfonamidofenil)p iperazin-1-il(butil)-1,3-dioxoperhidropirrolo)1,2-c(imidazol |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU9073098A (es) |
ES (1) | ES2129370B1 (es) |
WO (1) | WO1999015527A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7351732B2 (en) | 2002-07-31 | 2008-04-01 | Schwarz Pharma S.L. | Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006846A1 (es) * | 1994-09-01 | 1996-03-07 | Universidad Complutense De Madrid | Nuevos derivados de arilpiperazinas |
-
1997
- 1997-09-23 ES ES9701987A patent/ES2129370B1/es not_active Expired - Fee Related
-
1998
- 1998-09-15 WO PCT/ES1998/000250 patent/WO1999015527A1/es active Application Filing
- 1998-09-15 AU AU90730/98A patent/AU9073098A/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006846A1 (es) * | 1994-09-01 | 1996-03-07 | Universidad Complutense De Madrid | Nuevos derivados de arilpiperazinas |
Non-Patent Citations (2)
Title |
---|
Journal Medicinal Chemistry, Vol. 39, paginas 4439-4450, 1996. M.L. LOPEZ-RODRIGUEZ et al. "Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines". Pagina 4440, esquema 1, mÉtodo C. * |
Journal Medicinal Chemistry. Vol. 32, paginas 1052-1056, 1989. G.E. MARTIN et al. "Activity of Aromatic Substituted Phenylpiperazines Lacking Affinity for Dopamine Binding Sites in a Preclinical Test of Antipsychotic Efficacy". Esquema 1, tabla 1, compuesto 1q. * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7351732B2 (en) | 2002-07-31 | 2008-04-01 | Schwarz Pharma S.L. | Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications |
Also Published As
Publication number | Publication date |
---|---|
WO1999015527A1 (es) | 1999-04-01 |
AU9073098A (en) | 1999-04-12 |
ES2129370B1 (es) | 2000-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUT60719A (en) | Process for producing 3-aminopiperidine derivatives | |
FI920217A (fi) | Angiotensin ii receptor blockerande 2,3,6-substituerade kinazolinoner. | |
WO2000047583A8 (en) | Cyclic substituted fused pyrrolocarbazoles and isoindolones | |
DE69709938D1 (de) | N-benzylpiperidin- und tetrahydropyridin-derivate | |
ES2122905A1 (es) | Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato). | |
SK1452000A3 (en) | Pyrrolidine-3-carboxylic acid derivatives and their use as endothelin antagonists | |
HU9203761D0 (en) | Method for producing substituted pyridine derivatives | |
EG19361A (en) | A process for the preparation of piperidine compound having local anaesthetica and analgetic | |
EA200300579A1 (ru) | Соединение лактама | |
WO1999062893A3 (de) | Neue neurokininantagonisten, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen | |
ES2129370A1 (es) | Procedimiento para la obtencion del 2-(4-(4-(m-etilsulfonamidofenil)p iperazin-1-il(butil)-1,3-dioxoperhidropirrolo)1,2-c(imidazol | |
MX9603272A (es) | Nuevos derivados de aminoacidos, procedimiento para su preparacion y composiciones farmaceuticas que contienen estos compuestos. | |
PL320355A1 (en) | Salts of ethyl 3-(2-(4-(4-amino-imino-methyl)-phenyl)-4-methyl-2,5-diketioimidazolydinyl-1)-acetylamine)3-phenylpropionate of valuable pharmacological properties and method of obtaining them as well as pharmaceutic preparation and method of obtaining same | |
HU9400020D0 (en) | New process for producing sulphur-derivatives of imidazole, and the obtained new intermediates | |
MD554G2 (ro) | Derivaţi noi ai triazolpirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin | |
DK0804186T3 (da) | Indolditerpenalkaloidforbindelser | |
PT78161A (de) | Verfahren zur herstellung von 4-amino-6,7-dimethoxy-2-<4-(furo--2-yl)-piperazin-1-yl>-chinazolin und dessen physiologisch annehmabarer salze | |
ES2123599T3 (es) | Procedimiento para la produccion de 2-halogeno-4,6-dialcoxipirimidinas. | |
MY116365A (en) | Process for the preparation of the (-)-n-methyl-n [4-(4-phenyl-4-acetyl-aminopiperidin-1-yl)-2-(3,4-dichlorophenyl) butyl]-benzamide and its pharmaceutically acceptable salts | |
YU46441B (sh) | Postupak za dobijanje 8{-/4-(2-pirimidinil)-1-piperazinil/butil}-8-aza-1-spiro/4,5/-dekan-7,9-diona | |
DK0492350T3 (da) | Fremgangsmåde til fremstilling af (S)-vinyl- og (S)-allenyl-GABA | |
ES8707206A1 (es) | Procedimiento para preparar derivados de oxadiazolilimidazobenzodiazepina | |
YU62302A (sh) | Postupak za izradu jedinjenja 2-(4-alkil-1-piperazinil)- benzaldehida i benzilidenila | |
CA2267510A1 (en) | Process for manufacturing alpha-1l-adrenoceptor antagonists | |
HUT44759A (en) | Process for producing 2-acyl-3,4-dialkoxy-aniline derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990601 Kind code of ref document: A1 Effective date: 19990601 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20180102 |