ES2127695A1 - Process for the reduction of platelet factor 4 in plasma proteins having affinity to heparin - Google Patents
Process for the reduction of platelet factor 4 in plasma proteins having affinity to heparinInfo
- Publication number
- ES2127695A1 ES2127695A1 ES09700301A ES9700301A ES2127695A1 ES 2127695 A1 ES2127695 A1 ES 2127695A1 ES 09700301 A ES09700301 A ES 09700301A ES 9700301 A ES9700301 A ES 9700301A ES 2127695 A1 ES2127695 A1 ES 2127695A1
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- affinity
- platelet factor
- plasma proteins
- reduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Process for the reduction of platelet factor 4 in plasma proteins having affinity to heparin. The process for reducing the platelet factor 4 content of plasma proteins which have affinity to heparin comprises the separation of an original platelet material having high affinity for heparin in comparison with proteins of therapeutic interest derived from human plasma which contain the said contaminant by selective adsorption through an adsorbent having a very low capacity for non- specific protein adsorption, the adsorbent preferably being a polysulphone resin or derivatives of the aryl or phenylsulphone type and preferably the original platelet material having a high affinity for heparin is platelet factor 4 (FP4).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700301A ES2127695B1 (en) | 1997-02-14 | 1997-02-14 | PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700301A ES2127695B1 (en) | 1997-02-14 | 1997-02-14 | PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2127695A1 true ES2127695A1 (en) | 1999-04-16 |
ES2127695B1 ES2127695B1 (en) | 2000-03-16 |
Family
ID=8298242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9700301A Expired - Fee Related ES2127695B1 (en) | 1997-02-14 | 1997-02-14 | PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2127695B1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0317376A1 (en) * | 1987-10-23 | 1989-05-24 | Centre Regional De Transfusion Sanguine De Lille | Preparation of a concentrate of high-purity human factor IX and of other plasma proteins |
WO1990004609A1 (en) * | 1988-10-17 | 1990-05-03 | Sepracor, Inc. | Process for the covalent surface modification of hydrophobic polymers and articles made therefrom |
US5391580A (en) * | 1992-03-20 | 1995-02-21 | Anatrace Inc. | Poly(sulfone-alpha-olefin) composite permselective membrane article for use in blood oxygenation |
EP0842694A1 (en) * | 1996-03-21 | 1998-05-20 | Kaneka Corporation | Hollow yarn membrane used for blood purification and blood purifier |
-
1997
- 1997-02-14 ES ES9700301A patent/ES2127695B1/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0317376A1 (en) * | 1987-10-23 | 1989-05-24 | Centre Regional De Transfusion Sanguine De Lille | Preparation of a concentrate of high-purity human factor IX and of other plasma proteins |
WO1990004609A1 (en) * | 1988-10-17 | 1990-05-03 | Sepracor, Inc. | Process for the covalent surface modification of hydrophobic polymers and articles made therefrom |
US5391580A (en) * | 1992-03-20 | 1995-02-21 | Anatrace Inc. | Poly(sulfone-alpha-olefin) composite permselective membrane article for use in blood oxygenation |
EP0842694A1 (en) * | 1996-03-21 | 1998-05-20 | Kaneka Corporation | Hollow yarn membrane used for blood purification and blood purifier |
Also Published As
Publication number | Publication date |
---|---|
ES2127695B1 (en) | 2000-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990416 Kind code of ref document: A1 Effective date: 19990416 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20170526 |