ES2127695A1 - Process for the reduction of platelet factor 4 in plasma proteins having affinity to heparin - Google Patents

Process for the reduction of platelet factor 4 in plasma proteins having affinity to heparin

Info

Publication number
ES2127695A1
ES2127695A1 ES09700301A ES9700301A ES2127695A1 ES 2127695 A1 ES2127695 A1 ES 2127695A1 ES 09700301 A ES09700301 A ES 09700301A ES 9700301 A ES9700301 A ES 9700301A ES 2127695 A1 ES2127695 A1 ES 2127695A1
Authority
ES
Spain
Prior art keywords
heparin
affinity
platelet factor
plasma proteins
reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09700301A
Other languages
Spanish (es)
Other versions
ES2127695B1 (en
Inventor
Debart Pere Ristol
Rodriguez Jesus Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grifols SA
Original Assignee
Grifols SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grifols SA filed Critical Grifols SA
Priority to ES9700301A priority Critical patent/ES2127695B1/en
Publication of ES2127695A1 publication Critical patent/ES2127695A1/en
Application granted granted Critical
Publication of ES2127695B1 publication Critical patent/ES2127695B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Process for the reduction of platelet factor 4 in plasma proteins having affinity to heparin. The process for reducing the platelet factor 4 content of plasma proteins which have affinity to heparin comprises the separation of an original platelet material having high affinity for heparin in comparison with proteins of therapeutic interest derived from human plasma which contain the said contaminant by selective adsorption through an adsorbent having a very low capacity for non- specific protein adsorption, the adsorbent preferably being a polysulphone resin or derivatives of the aryl or phenylsulphone type and preferably the original platelet material having a high affinity for heparin is platelet factor 4 (FP4).
ES9700301A 1997-02-14 1997-02-14 PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN. Expired - Fee Related ES2127695B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9700301A ES2127695B1 (en) 1997-02-14 1997-02-14 PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9700301A ES2127695B1 (en) 1997-02-14 1997-02-14 PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN.

Publications (2)

Publication Number Publication Date
ES2127695A1 true ES2127695A1 (en) 1999-04-16
ES2127695B1 ES2127695B1 (en) 2000-03-16

Family

ID=8298242

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9700301A Expired - Fee Related ES2127695B1 (en) 1997-02-14 1997-02-14 PROCEDURE FOR THE REDUCTION OF THE CONTENT OF PLATELET FACTOR 4 IN PLASMA PROTEINS THAT HAVE AFFINITY TO HEPARIN.

Country Status (1)

Country Link
ES (1) ES2127695B1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317376A1 (en) * 1987-10-23 1989-05-24 Centre Regional De Transfusion Sanguine De Lille Preparation of a concentrate of high-purity human factor IX and of other plasma proteins
WO1990004609A1 (en) * 1988-10-17 1990-05-03 Sepracor, Inc. Process for the covalent surface modification of hydrophobic polymers and articles made therefrom
US5391580A (en) * 1992-03-20 1995-02-21 Anatrace Inc. Poly(sulfone-alpha-olefin) composite permselective membrane article for use in blood oxygenation
EP0842694A1 (en) * 1996-03-21 1998-05-20 Kaneka Corporation Hollow yarn membrane used for blood purification and blood purifier

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317376A1 (en) * 1987-10-23 1989-05-24 Centre Regional De Transfusion Sanguine De Lille Preparation of a concentrate of high-purity human factor IX and of other plasma proteins
WO1990004609A1 (en) * 1988-10-17 1990-05-03 Sepracor, Inc. Process for the covalent surface modification of hydrophobic polymers and articles made therefrom
US5391580A (en) * 1992-03-20 1995-02-21 Anatrace Inc. Poly(sulfone-alpha-olefin) composite permselective membrane article for use in blood oxygenation
EP0842694A1 (en) * 1996-03-21 1998-05-20 Kaneka Corporation Hollow yarn membrane used for blood purification and blood purifier

Also Published As

Publication number Publication date
ES2127695B1 (en) 2000-03-16

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