ES2125237T3 - Estabilizacion de substancias macromoleculares biologicas y de otros compuestos organicos. - Google Patents

Estabilizacion de substancias macromoleculares biologicas y de otros compuestos organicos.

Info

Publication number
ES2125237T3
ES2125237T3 ES91909487T ES91909487T ES2125237T3 ES 2125237 T3 ES2125237 T3 ES 2125237T3 ES 91909487 T ES91909487 T ES 91909487T ES 91909487 T ES91909487 T ES 91909487T ES 2125237 T3 ES2125237 T3 ES 2125237T3
Authority
ES
Spain
Prior art keywords
organic compounds
stabilization
macromolecular substances
sugar
biological macromolecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91909487T
Other languages
English (en)
Inventor
Bruce Joseph Roser
Camilo Colaco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Holdings Cambridge Ltd
Original Assignee
Quadrant Holdings Cambridge Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadrant Holdings Cambridge Ltd filed Critical Quadrant Holdings Cambridge Ltd
Application granted granted Critical
Publication of ES2125237T3 publication Critical patent/ES2125237T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

UN METODO PARA PRESERVAR SUSTANCIAS BIOLOGICAS DELICADAS O COMPUESTOS ORGANICOS (A) EN ESTADO SECO Y/O (B) A ELEVADAS TEMPERATURAS Y/O (C) BAJO IRRADIACION COMPRENDE INCORPORAR A UN SISTEMA QUE CONTIENE LAS SUSTANCIAS DICHAS O COMPONENTES, UN AZUCAR O UN DERIVADO DE ESTE ELEGIDO ENTRE (I) UN GLUCOSIDO NO REDUCIDO DE UN COMPUESTO POLIALCOHOLICO SELECCIONADO DE ENTRE ALCOHOLES DE AZUCAR Y OTRO POLIALCOHOLES NO RAMIFICADOS O (II) UN OLISACARIDO ELEGIDO ENTRE RAFINOSA, ESTAQUIOSA Y MELECITOSA.
ES91909487T 1990-05-14 1991-05-14 Estabilizacion de substancias macromoleculares biologicas y de otros compuestos organicos. Expired - Lifetime ES2125237T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909010742A GB9010742D0 (en) 1990-05-14 1990-05-14 Stabilization of biological macromolecular substances

Publications (1)

Publication Number Publication Date
ES2125237T3 true ES2125237T3 (es) 1999-03-01

Family

ID=10675945

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91909487T Expired - Lifetime ES2125237T3 (es) 1990-05-14 1991-05-14 Estabilizacion de substancias macromoleculares biologicas y de otros compuestos organicos.

Country Status (9)

Country Link
EP (1) EP0541556B1 (es)
JP (1) JP3101320B2 (es)
AT (1) ATE171209T1 (es)
AU (1) AU7872591A (es)
DE (1) DE69130223T2 (es)
DK (1) DK0541556T3 (es)
ES (1) ES2125237T3 (es)
GB (1) GB9010742D0 (es)
WO (1) WO1991018091A1 (es)

Cited By (1)

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ES2214144A1 (es) * 2003-02-26 2004-09-01 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Composicion estabilizada para ensayos fluorimetricos, colorimetricos o quimio-luminiscentes, kits que la contienen y procedimiento para su obtencion.

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US5298406A (en) * 1992-09-14 1994-03-29 E. I. Du Pont De Nemours And Company Formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
EP0748225B1 (en) * 1994-03-04 2004-06-09 Genentech, Inc. PHARMACEUTICALLY ACCEPTABLE DNase FORMULATION
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
WO1996002631A1 (fr) * 1994-07-20 1996-02-01 Kyowa Hakko Kogyo Co., Ltd. Procede pour produire une carboxyesterase seche stabilisee
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
EP0773781B1 (en) * 1994-08-04 2003-10-22 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
SE9404468D0 (sv) * 1994-12-22 1994-12-22 Astra Ab Powder formulations
SE9501189D0 (sv) * 1995-03-31 1995-03-31 Pharmacia Ab Protein formulation
GB9508691D0 (en) * 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
US6964771B1 (en) 1995-06-07 2005-11-15 Elan Drug Delivery Limited Method for stably incorporating substances within dry, foamed glass matrices
ES2194992T3 (es) * 1995-06-07 2003-12-01 Elan Drug Delivery Ltd Procedimientos para la incorporacion estable de sustancias en matrices vitreas secas esponjosas, y composiciones asi obtenidas.
IT1276684B1 (it) * 1995-06-08 1997-11-03 Bioextech Inc Formulazioni idrosolubili di collagenasi stabilizzata e procedimento per la loro preparazione
ID21635A (id) * 1996-12-20 1999-07-08 Astra Pharma Prod Komposisi farmasi untuk pengeringan beku
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
EP0913177A1 (de) 1997-11-03 1999-05-06 Roche Diagnostics GmbH Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung
DE19818842C1 (de) * 1998-04-28 2000-01-05 Suedzucker Ag Erkältungsmittel
US6225289B1 (en) 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
US6190701B1 (en) 1999-03-17 2001-02-20 Peter M. Ronai Composition and method for stable injectable liquids
IL149778A0 (en) * 1999-11-22 2002-11-10 Universal Preservation Technologies Inc Preservation of sensitive biological material
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
EP1449523A1 (en) * 2000-10-13 2004-08-25 Cambridge Biostability Ltd Composition and method for stable injectable liquids
US6872357B1 (en) 2000-11-22 2005-03-29 Quadrant Drug Delivery Limited Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying
ES2180416B1 (es) 2001-03-12 2004-06-01 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen.
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
CA2480270A1 (en) * 2002-04-03 2003-10-09 Solvay Pharmaceuticals B.V. Stabilized natural cannabinoid formulation
RU2011110459A (ru) 2008-08-21 2012-09-27 Октафарма АГ (CH) Рекомбинантно полученный человеческий фактор viii и ix
JP5953229B2 (ja) * 2009-06-12 2016-07-20 マイクロニクス， インコーポレイテッド マイクロ流体デバイス内でオンボード試薬を脱水保存する組成物および方法
WO2010144682A1 (en) * 2009-06-12 2010-12-16 Micronics, Inc. Rehydratable matrices for dry storage of taq polymerase in a microfluidic device
US20130157265A1 (en) 2009-10-22 2013-06-20 Jesus Mingorance Cruz Composition, method and kit for detecting bacteria by means of sequencing
JP2019043961A (ja) * 2010-04-20 2019-03-22 オクタファルマ・アーゲー 医薬タンパク質の新規な安定化剤
AU2015202570B2 (en) * 2010-04-20 2017-04-06 Octapharma Ag New stabilizing agent for pharmaceutical proteins
ES2545893T3 (es) * 2010-04-20 2015-09-16 Octapharma Ag Nuevo agente estabilizante para proteínas farmacéuticas
GB201901818D0 (en) * 2010-07-07 2019-04-03 Thermo Fisher Scient Gmbh Analyte mass spectrometry quantitation using a universal reporter
US9480966B2 (en) 2012-04-30 2016-11-01 General Electric Company Substrates and methods for collection, stabilization and elution of biomolecules
GB201301457D0 (en) 2013-01-28 2013-03-13 Fluorogenics Ltd Freeze-dried composition
US9534214B2 (en) * 2013-10-31 2017-01-03 General Electric Company Substrates and associated methods for elution of nucleic acids
KR102495546B1 (ko) * 2014-04-25 2023-02-06 글로벌 라이프 사이언시스 솔루션즈 오퍼레이션스 유케이 엘티디 생체분자의 수집, 안정화 및 용리를 위한 기재 및 방법
FR3034418B1 (fr) 2015-04-03 2018-09-28 Roquette Freres Utilisation de combinaisons particulieres de carbohydrates pour stabiliser des proteines, et compositions proteiques contenant de telles combinaisons
CN108473932B (zh) 2015-09-09 2022-07-15 集联健康有限公司 用于样品收集、稳定化和保存的系统、方法和装置
TW202425920A (zh) 2017-01-10 2024-07-01 美商集聯健康有限公司 筒匣組裝件

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FR7773M (es) * 1968-06-14 1970-03-23
US4891319A (en) * 1985-07-09 1990-01-02 Quadrant Bioresources Limited Protection of proteins and the like
GB8604983D0 (en) * 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
GB8826429D0 (en) * 1988-11-11 1988-12-14 Univ Leeds Ind Service Ltd Enzyme stabilisation systems
GB8903593D0 (en) * 1989-02-16 1989-04-05 Pafra Ltd Storage of materials

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2214144A1 (es) * 2003-02-26 2004-09-01 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Composicion estabilizada para ensayos fluorimetricos, colorimetricos o quimio-luminiscentes, kits que la contienen y procedimiento para su obtencion.
WO2004076656A1 (es) * 2003-02-26 2004-09-10 Biotools Biotechnological & Medical Laboratories, S.A. Composición estabilizada para ensayos fluorimétricos, colorimétricos o quimio-luminiscentes, kits que la contienen y procedimiento para su obtención

Also Published As

Publication number Publication date
ATE171209T1 (de) 1998-10-15
GB9010742D0 (en) 1990-07-04
JP3101320B2 (ja) 2000-10-23
JPH05508315A (ja) 1993-11-25
DE69130223T2 (de) 1999-08-26
EP0541556B1 (en) 1998-09-16
EP0541556A1 (en) 1993-05-19
DE69130223D1 (de) 1998-10-22
AU7872591A (en) 1991-12-10
WO1991018091A1 (en) 1991-11-28
DK0541556T3 (da) 1999-06-14

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