ES2123844T3 - Ampolla que contiene una solucion inyectable concentrada de sales de metales alcalinos de folatos reducidos. - Google Patents

Ampolla que contiene una solucion inyectable concentrada de sales de metales alcalinos de folatos reducidos.

Info

Publication number
ES2123844T3
ES2123844T3 ES95101954T ES95101954T ES2123844T3 ES 2123844 T3 ES2123844 T3 ES 2123844T3 ES 95101954 T ES95101954 T ES 95101954T ES 95101954 T ES95101954 T ES 95101954T ES 2123844 T3 ES2123844 T3 ES 2123844T3
Authority
ES
Spain
Prior art keywords
salts
injectable solution
solution concentrated
alkaline metals
ampoule containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95101954T
Other languages
English (en)
Inventor
Peter Buchs
Fabrizio Marazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cerbios Pharma SA
Original Assignee
Cerbios Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4186893&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2123844(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cerbios Pharma SA filed Critical Cerbios Pharma SA
Application granted granted Critical
Publication of ES2123844T3 publication Critical patent/ES2123844T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA SOLUCION ESTABLE, CONCENTRADA DE ACUERDO CON LA INVENCION, EN PARTICULAR UNA SOLUCION DE INYECCION, SE CARACTERIZA PORQUE JUNTO A AGUA CONTIENE BIEN LEUCOVORIN-SODIO O LEUCOVORIN-POTASIO O SODIO - N - (5) - METIL -5,6,7,8 - ACIDO TETRAHIDROFOLICO O POTASIO - N(5) - METIL - 5,6,7,8 - ACIDO TETRAHIDROFOLICO. SE DESCRIBE TAMBIEN UN PROCESO PARA LA ELABORACION DE ESTA SOLUCION ASI COMO SUS UTILIZACIONES.
ES95101954T 1994-02-14 1995-02-14 Ampolla que contiene una solucion inyectable concentrada de sales de metales alcalinos de folatos reducidos. Expired - Lifetime ES2123844T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH00432/94A CH687062A5 (de) 1994-02-14 1994-02-14 Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.

Publications (1)

Publication Number Publication Date
ES2123844T3 true ES2123844T3 (es) 1999-01-16

Family

ID=4186893

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95101954T Expired - Lifetime ES2123844T3 (es) 1994-02-14 1995-02-14 Ampolla que contiene una solucion inyectable concentrada de sales de metales alcalinos de folatos reducidos.

Country Status (5)

Country Link
US (1) US5814635A (es)
EP (1) EP0667159B1 (es)
CH (1) CH687062A5 (es)
DE (1) DE59503740D1 (es)
ES (1) ES2123844T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9400530A (nl) 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
EP1956906A4 (en) 2005-11-09 2009-12-30 Combinatorx Inc METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES
WO2014025807A1 (en) 2012-08-06 2014-02-13 Spectrum Pharmaceuticals, Inc. Pharmaceutical compositions comprising l-leucovorin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2741608A (en) * 1951-03-08 1956-04-10 Research Corp 5-formyl-5,6,7,8-tetrahydropteroic acid and amides thereof and method of preparing same
US2695860A (en) * 1952-04-29 1954-11-30 American Cyanamid Co Stabilized pteroyl solutions
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
US4350659A (en) * 1981-07-30 1982-09-21 Corning Glass Works Stabilization of sensitive biologically active intermediate metabolites such as folic acid derivatives
CH673459A5 (es) * 1987-05-15 1990-03-15 Eprova Ag
US4931441A (en) * 1988-11-09 1990-06-05 Luitpold Pharmaceuticals, Inc. Stabilized aqueous leucovorin calcium compositions
WO1990010460A1 (en) * 1989-03-13 1990-09-20 Kenneth Naoyuki Matsumura Method for reducing side effects of a drug
NL8901432A (nl) * 1989-06-06 1991-01-02 Pharmachemie Bv Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.
US5173488A (en) * 1989-08-21 1992-12-22 American Cyanamid Company Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
ES2076263T3 (es) * 1989-08-21 1995-11-01 American Cyanamid Co Formulacion farmaceutica inyectable estable, para acido folico y sales de leucovorina y procedimiento.
NL9400530A (nl) * 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.

Also Published As

Publication number Publication date
EP0667159A2 (de) 1995-08-16
CH687062A5 (de) 1996-09-13
DE59503740D1 (de) 1998-11-05
EP0667159B1 (de) 1998-09-30
US5814635A (en) 1998-09-29
EP0667159A3 (de) 1995-11-29

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