ES2122245T3 - Derivados de piperazina como ligandos 5-ht1a. - Google Patents

Derivados de piperazina como ligandos 5-ht1a.

Info

Publication number
ES2122245T3
ES2122245T3 ES94909244T ES94909244T ES2122245T3 ES 2122245 T3 ES2122245 T3 ES 2122245T3 ES 94909244 T ES94909244 T ES 94909244T ES 94909244 T ES94909244 T ES 94909244T ES 2122245 T3 ES2122245 T3 ES 2122245T3
Authority
ES
Spain
Prior art keywords
pct
ht1a
cycloalkyl
lower alkyl
ligands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909244T
Other languages
English (en)
Inventor
Mark Antony Ashwell
Ian Anthony Cliffe
Terence James Ward
Alan Chapman White
Graham John Warrellow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Application granted granted Critical
Publication of ES2122245T3 publication Critical patent/ES2122245T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

DERIVADOS DE PIPERACINA DE FORMULA (I) Y SUS SALES SON AGENTES AGLOMERANTES 5-HT{SUB.1A}, Y PUEDEN SER UTILIZADOS, POR EJEMPLO, COMO ANXIOLITICOS. EN LA FORMULA R, R{SUP.2}, Y R{SUP.4} SON HIDROGENO O ALQUIL BAJO, R{SUP.1} ES ARIL MONO O BICICLICO O HETEROARIL, R{SUP.3} ES ALQUIL BAJO O CICLOALQUIL, A ES UNA CADENA ALQUILENA Y X ES -CO-, -CR{SUP.5}OH- (DONDE R{SUP.5} ES HIDROGENO, ALQUIL BAJO O CICLOALQUIL), -S-, -SO- O -SO{SUB.2}O X PUEDE SER -(CH{SUB.2}){SUB.N}- (DONDE N ES 0,1 O 2) DONDE R{SUP.3} ES CICLOALQUIL.
ES94909244T 1993-03-24 1994-03-17 Derivados de piperazina como ligandos 5-ht1a. Expired - Lifetime ES2122245T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939306103A GB9306103D0 (en) 1993-03-24 1993-03-24 Piperazine derivatives

Publications (1)

Publication Number Publication Date
ES2122245T3 true ES2122245T3 (es) 1998-12-16

Family

ID=10732658

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909244T Expired - Lifetime ES2122245T3 (es) 1993-03-24 1994-03-17 Derivados de piperazina como ligandos 5-ht1a.

Country Status (12)

Country Link
US (1) US5693642A (es)
EP (1) EP0690845B1 (es)
JP (1) JPH08508031A (es)
AT (1) ATE170841T1 (es)
AU (1) AU6216394A (es)
DE (1) DE69413213T2 (es)
DK (1) DK0690845T3 (es)
ES (1) ES2122245T3 (es)
GB (1) GB9306103D0 (es)
TW (1) TW281673B (es)
WO (1) WO1994021610A1 (es)
ZA (1) ZA941934B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
WO1999006382A1 (en) * 1997-08-01 1999-02-11 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
US6271234B1 (en) 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
UA66370C2 (en) 1997-12-16 2004-05-17 Lilly Co Eli Arylpiperazines having activity to setotonin 1 receptors
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
CA2334254A1 (en) * 1998-06-15 1999-12-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US6743796B2 (en) 2001-05-07 2004-06-01 Wyeth Piperazinyl-isatins
US7071197B2 (en) * 2002-06-14 2006-07-04 Recordati S.A. N,N-disubstituted diazocycloalkanes
US20040072839A1 (en) * 2002-06-14 2004-04-15 Amedeo Leonardi 1-Phenylalkylpiperazines
US7419980B2 (en) * 2003-10-14 2008-09-02 Wyeth Fused-aryl and heteroaryl derivatives and methods of their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
MX9201991A (es) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.

Also Published As

Publication number Publication date
US5693642A (en) 1997-12-02
TW281673B (es) 1996-07-21
GB9306103D0 (en) 1993-05-12
DK0690845T3 (da) 1999-02-22
ZA941934B (en) 1995-09-18
EP0690845B1 (en) 1998-09-09
JPH08508031A (ja) 1996-08-27
ATE170841T1 (de) 1998-09-15
DE69413213D1 (de) 1998-10-15
WO1994021610A1 (en) 1994-09-29
AU6216394A (en) 1994-10-11
EP0690845A1 (en) 1996-01-10
DE69413213T2 (de) 1999-05-06

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