ES2119945T3 - Derivados de indol, sus sales y agentes para el tratamiento de las enfermedades cardiacas que los contienen. - Google Patents

Derivados de indol, sus sales y agentes para el tratamiento de las enfermedades cardiacas que los contienen.

Info

Publication number
ES2119945T3
ES2119945T3 ES94117102T ES94117102T ES2119945T3 ES 2119945 T3 ES2119945 T3 ES 2119945T3 ES 94117102 T ES94117102 T ES 94117102T ES 94117102 T ES94117102 T ES 94117102T ES 2119945 T3 ES2119945 T3 ES 2119945T3
Authority
ES
Spain
Prior art keywords
chem
action
indol
derivatives
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94117102T
Other languages
English (en)
Inventor
Yoshinori Kyotani
Katsumi Kawamine
Tsutomu Toma
Tadaaki Ohgiya
Takashi Yamaguchi
Kazuhiro Onogi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of ES2119945T3 publication Critical patent/ES2119945T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

UN DERIVADO DE INDOL REPRESENTADO POR LA FORMULA (1), EN LA QUE A ES UN GRUPO O EN DONDE R10 ES HIDROGENO O ALQUILO INFERIOR, LAS LINEAS DE PUNTOS PUEDEN SER OPCIONALMENTE REENVIADAS Y DE R1 A R9 REPRESENTAN VARIOS GRUPOS SUSTITUIDORES. EL COMPUESTO (1) PRESENTA UNA ACCION INOTROPICA POSITIVA EN EL MUSCULO CARDIACO, UNA ACCION ANTIARRITMICA Y UNA ACCION VASOLITADORA SIN AUMENTAR EL RITMO DEL CORAZON. UN AGENTE TERAPEUTICO PARA UNA AFECCION CARDIACA QUE CONTENGA ESTE COMPUESTO COMO COMPONENTE EFECTIVO ES EXTREMADAMENTE EFECTIVO PARA EL TRATAMIENTO DE FALLOS CARDIACOS Y DE LA ARRITMIA.
ES94117102T 1993-10-29 1994-10-28 Derivados de indol, sus sales y agentes para el tratamiento de las enfermedades cardiacas que los contienen. Expired - Lifetime ES2119945T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27177093 1993-10-29

Publications (1)

Publication Number Publication Date
ES2119945T3 true ES2119945T3 (es) 1998-10-16

Family

ID=17504610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94117102T Expired - Lifetime ES2119945T3 (es) 1993-10-29 1994-10-28 Derivados de indol, sus sales y agentes para el tratamiento de las enfermedades cardiacas que los contienen.

Country Status (9)

Country Link
US (1) US5510366A (es)
EP (1) EP0653426B1 (es)
KR (1) KR100327264B1 (es)
AT (1) ATE168690T1 (es)
CA (1) CA2134608C (es)
DE (1) DE69411852T2 (es)
DK (1) DK0653426T3 (es)
ES (1) ES2119945T3 (es)
SI (1) SI0653426T1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US20040097433A1 (en) * 2002-11-15 2004-05-20 Sekhar Boddupalli Chroman derivatives for the reduction of inflammation symptoms
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
BRPI0618643A2 (pt) 2005-11-09 2011-09-06 Combinatorx Inc composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1159459A (en) * 1980-12-11 1983-12-27 Andre A. Asselin 6,7,8,9-tetrahydro-3h-benz¬e| indolamine derivatives
DE3525564A1 (de) * 1985-07-15 1987-02-05 Schering Ag Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
JPH05505599A (ja) * 1990-03-15 1993-08-19 ジ・アップジョン・カンパニー 治療上有用な複素環インドール化合物類

Also Published As

Publication number Publication date
EP0653426B1 (en) 1998-07-22
KR950011446A (ko) 1995-05-15
DK0653426T3 (da) 1998-10-26
CA2134608A1 (en) 1995-04-30
SI0653426T1 (en) 1998-12-31
KR100327264B1 (ko) 2002-07-02
CA2134608C (en) 2004-12-07
DE69411852T2 (de) 1998-12-03
ATE168690T1 (de) 1998-08-15
DE69411852D1 (de) 1998-08-27
US5510366A (en) 1996-04-23
EP0653426A1 (en) 1995-05-17

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