ES2117558A1 - Composicion oftalmica topica que comprende un derivado de 2-(4-(azolilbutil)-piperazinil-metil)-benzimidazol, principalmente para el tratamiento de la conjuntivitis alergica. - Google Patents

Composicion oftalmica topica que comprende un derivado de 2-(4-(azolilbutil)-piperazinil-metil)-benzimidazol, principalmente para el tratamiento de la conjuntivitis alergica.

Info

Publication number
ES2117558A1
ES2117558A1 ES09600606A ES9600606A ES2117558A1 ES 2117558 A1 ES2117558 A1 ES 2117558A1 ES 09600606 A ES09600606 A ES 09600606A ES 9600606 A ES9600606 A ES 9600606A ES 2117558 A1 ES2117558 A1 ES 2117558A1
Authority
ES
Spain
Prior art keywords
radical
methyl
allergic conjunctivitis
treating allergic
azolylbutyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09600606A
Other languages
English (en)
Other versions
ES2117558B1 (es
Inventor
Altisent Maria Rosa Cuberes
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2117558A1 publication Critical patent/ES2117558A1/es
Application granted granted Critical
Publication of ES2117558B1 publication Critical patent/ES2117558B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSICION OFTALMICA TOPICA QUE COMPRENDE UN DERIVADO DE 2-[4-(AZOLILBUTIL)-PIPERAZINIL-METIL]-BENZIMIDAZOL, PRINCIPALMENTE PARA EL TRATAMIENTO DE LA CONJUNTIVITIS ALERGICA. COMPRENDE POR LO MENOS UN COMPUESTO DE FORMULA GENERAL I. EN LA CUAL: N PUEDE TENER LOS VALORES 0 O 1, M PUEDE TENER LOS VALORES 2 O 3, Y HET REPRESENTA UN RADICAL HETEROAROMATICO DE FORMULA EN LA CUAL: X, Y, Z Y W, IGUALES O DIFERENTES, REPRESENTAN UN ATOMO DE NITROGENO O UN ATOMO DE CARBONO UNIDO A UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN RADICAL METILO, UN RADICAL CARBOXILATO DE ETILO, UN RADICAL CARBOXILICO O UN RADICAL SULFONICO, Y SUS SALES FISIOLOGICAMENTE ACEPTABLES, ASOCIADOS A UN VEHICULO OFTALMICAMENTE ACEPTABLE, EN PARTICULAR PARA EL TRATAMIENTO DE LA CONJUNTIVITIS ALERGICA.
ES09600606A 1995-03-14 1996-03-13 Composicion oftalmica topica que comprende un derivado de 2-(4-(azolilbutil)-piperazinil-metil)-benzimidazol, principalmente para el tratamiento de la conjuntivitis alergica. Expired - Fee Related ES2117558B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9502910A FR2731618B1 (fr) 1995-03-14 1995-03-14 Composition ophtalmique topique comprenant un derive de 2-(4-(azolylbutyl)-piperazinyl-methyl)-benzimidazole, notamment pour le traitement de la conjonctivite allergique

Publications (2)

Publication Number Publication Date
ES2117558A1 true ES2117558A1 (es) 1998-08-01
ES2117558B1 ES2117558B1 (es) 1999-09-16

Family

ID=9476989

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09600606A Expired - Fee Related ES2117558B1 (es) 1995-03-14 1996-03-13 Composicion oftalmica topica que comprende un derivado de 2-(4-(azolilbutil)-piperazinil-metil)-benzimidazol, principalmente para el tratamiento de la conjuntivitis alergica.

Country Status (9)

Country Link
US (1) US5641781A (es)
EP (1) EP0760663A1 (es)
JP (1) JPH10500427A (es)
AU (1) AU718008B2 (es)
CA (1) CA2190187A1 (es)
ES (1) ES2117558B1 (es)
FR (1) FR2731618B1 (es)
WO (1) WO1996028161A1 (es)
ZA (1) ZA962060B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
WO2004037167A2 (en) * 2002-10-18 2004-05-06 Molichem Medicines, Inc. Methods of treating dry eye disease with lantibiotics
WO2005107787A1 (en) * 2004-05-06 2005-11-17 Molichem Medicines, Inc. Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions
WO2005115432A2 (en) * 2004-05-06 2005-12-08 Molichem Medicines, Inc. Treatment of ocular diseases and disorders using lantibiotic compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468884A1 (fr) * 1990-07-26 1992-01-29 Laboratorios Del Dr. Esteve, S.A. Nouveaux dérivés de benzimidazole, leur préparation, et leur application en tant que médicaments
EP0507696A1 (fr) * 1991-04-05 1992-10-07 Laboratorios Del Dr. Esteve, S.A. Antihistaminiques non sédatifs, dérivés de benzimidazole, leur procédé de préparation et leur utilisation en tant que médicaments.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3527256B2 (ja) * 1992-12-09 2004-05-17 ロート製薬株式会社 抗アレルギー点眼剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468884A1 (fr) * 1990-07-26 1992-01-29 Laboratorios Del Dr. Esteve, S.A. Nouveaux dérivés de benzimidazole, leur préparation, et leur application en tant que médicaments
EP0507696A1 (fr) * 1991-04-05 1992-10-07 Laboratorios Del Dr. Esteve, S.A. Antihistaminiques non sédatifs, dérivés de benzimidazole, leur procédé de préparation et leur utilisation en tant que médicaments.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YANNI, J.M. et al. Preclinical efficacy of emedastine a potent, selective Histamine H1 antagonist for topical ocular use. Journal of ocular Pharmacology, 1994, Vol. 10, n‘ 4, pßginas 665-675 * Todo el documento * *

Also Published As

Publication number Publication date
WO1996028161A1 (fr) 1996-09-19
FR2731618A1 (fr) 1996-09-20
ZA962060B (en) 1996-12-31
AU718008B2 (en) 2000-04-06
CA2190187A1 (fr) 1996-09-19
EP0760663A1 (fr) 1997-03-12
ES2117558B1 (es) 1999-09-16
FR2731618B1 (fr) 1997-08-01
US5641781A (en) 1997-06-24
JPH10500427A (ja) 1998-01-13
AU5145296A (en) 1996-10-02

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