ES2113664T3 - AMINO ACID DERIVATIVES AS NO SINTASA INHIBITORS. - Google Patents

AMINO ACID DERIVATIVES AS NO SINTASA INHIBITORS.

Info

Publication number
ES2113664T3
ES2113664T3 ES94918447T ES94918447T ES2113664T3 ES 2113664 T3 ES2113664 T3 ES 2113664T3 ES 94918447 T ES94918447 T ES 94918447T ES 94918447 T ES94918447 T ES 94918447T ES 2113664 T3 ES2113664 T3 ES 2113664T3
Authority
ES
Spain
Prior art keywords
sub
group
rent
sintasa
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94918447T
Other languages
Spanish (es)
Inventor
Barry George Shearer
Karl Witold Franzmann
Harold Francis Hodson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2113664T3 publication Critical patent/ES2113664T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I) Y SALES, ESTERES Y AMIDAS DE LOS MISMOS, DONDE R{SUP,1} ES UN GRUPO ALQUILO DE CADENA DIRECTA O RAMIFICADA C{SUB,1-6}, UN GRUPO CICLOALQUIL C{SUB,3-6}, UN GRUPO TIOL OPCIONALMENTE SUSTITUIDO POR UN GRUPO ALQUIL C{SUB,1-6}, O UN GRUPO AMINO OPCIONALMENTE SUSTITUIDO POR UNO O DOS GRUPOS DE ALQUILO O ALQUENIL; R{SUP,2} ES H, UN ALQUILO DE CADENA DIRECTA O RAMIFICADA C{SUB,1-7}, CICLOALQUIL C{SUB,3-6}, ALQUENIL C{SUB,2-7} O BENCIL; A ES UN CARBOCICLICO AROMATICO DE 5 O 6 ELEMENTOS O UN ANILLO HETEROCICLICO QUE PUEDE SER SUSTITUIDO OPCIONALMENTE POR UNO O MAS SUSTITUYENTES ADECUADOS TALES COMO, ALQUIL C{SUB,1-6}, ALCOXI C{SUB,1-6}, HIDROXI, HALO, NITRO, CIANO, ALQUIL C{SUB,1-6}TRIFLUORO, AMINO, ALQUILAMINO C{SUB,1-6} O ALQUILAMINO DI C{SUB,1-6}; R ES 0,1 O 2; S ES 0,1 O 2; SU USO EN MEDICINA Y EN PARTICULAR EN CONDICIONES QUE REQUIEREN LA INHIBICION DE LA ENZIMA SINTASA NO, FORMULACIONES FARMACEUTICAS Y PROCESOS PARA LA PREPARACION DE LOS MISMOS.COMPOUNDS OF FORMULA (I) AND SALTS, ESTERS AND AMIDES OF THE SAME, WHERE R {SUP, 1} IS A DIRECT OR BRANCHED CHAIN RENT GROUP C {SUB, 1-6}, A CYCLLOALKYL GROUP C {SUB, 3 -6}, A THIOL GROUP OPTIONALLY SUBSTITUTED BY AN ALKYL GROUP C {SUB, 1-6}, OR AN AMINO GROUP OPTIONALLY SUBSTITUTED BY ONE OR TWO GROUPS OF RENT OR ALKENYL; R {SUP, 2} IS H, A DIRECT OR BRANCHED CHAIN RENT C {SUB, 1-7}, CYCLLOALKYL C {SUB, 3-6}, ALQUENYL C {SUB, 2-7} OR BENCIL; A IS A 5 OR 6 ELEMENT AROMATIC CARBOCICLIC OR A HETERO-CYCLIC RING THAT CAN BE OPTIONALLY REPLACED BY ONE OR MORE SUITABLE SUBSTITUTES SUCH AS, ALKYL C {SUB, 1-6}, ALCOXI C {SUB, 1-6}, HIDROXI, HALO, NITRO, CIANO, ALQUIL C {SUB, 1-6} TRIFLUORO, AMINO, ALQUILAMINO C {SUB, 1-6} OR ALQUILAMINO DI C {SUB, 1-6}; R ES 0.1 O 2; S ES 0.1 O 2; ITS USE IN MEDICINE AND PARTICULARLY IN CONDITIONS THAT REQUIRE THE INHIBITION OF THE ENZYME SYNTHESA NO, PHARMACEUTICAL FORMULATIONS AND PROCESSES FOR THE PREPARATION OF THE SAME.

ES94918447T 1993-06-21 1994-06-20 AMINO ACID DERIVATIVES AS NO SINTASA INHIBITORS. Expired - Lifetime ES2113664T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939312761A GB9312761D0 (en) 1993-06-21 1993-06-21 Amino acid derivatives

Publications (1)

Publication Number Publication Date
ES2113664T3 true ES2113664T3 (en) 1998-05-01

Family

ID=10737511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94918447T Expired - Lifetime ES2113664T3 (en) 1993-06-21 1994-06-20 AMINO ACID DERIVATIVES AS NO SINTASA INHIBITORS.

Country Status (11)

Country Link
US (1) US5874472A (en)
EP (1) EP0705257B1 (en)
JP (1) JPH09501651A (en)
AT (1) ATE163932T1 (en)
AU (1) AU6976394A (en)
DE (1) DE69408988T2 (en)
DK (1) DK0705257T3 (en)
ES (1) ES2113664T3 (en)
GB (1) GB9312761D0 (en)
HU (1) HUT73169A (en)
WO (1) WO1995000505A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821267A (en) * 1993-10-21 1998-10-13 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
WO1995024382A1 (en) * 1994-03-10 1995-09-14 G.D. Searle & Co. L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
MX9605366A (en) * 1994-05-07 1997-12-31 Astra Ab Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase.
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
AU2629795A (en) 1994-12-12 1996-07-03 Chugai Seiyaku Kabushiki Kaisha Aniline derivative having the effect of inhibiting nitrogen monoxide synthase
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
WO1997046515A1 (en) * 1996-06-04 1997-12-11 Chugai Seiyaku Kabushiki Kaisha Substituted benzenes having nos inhibitory effects
US6291514B1 (en) 1998-02-09 2001-09-18 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
EP1054886B1 (en) * 1998-02-09 2002-09-04 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines as protease inhibitors, in particular as urokinase inhibitors
PT1062201E (en) * 1998-03-11 2005-02-28 Searle & Co HALOGENATED DERIVATIVES OF USED AMIDINE-AMINOACIDS AS INHIBITORS OF NITRIC ACID SYNTHASE
FR2784678B1 (en) * 1998-09-23 2002-11-29 Sod Conseils Rech Applic NOVEL N- (IMINOMETHYL) AMINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2783519B1 (en) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU2847200A (en) * 1999-01-27 2000-08-18 G.D. Searle & Co. Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors
CZ20012858A3 (en) * 1999-02-09 2002-05-15 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methyl amidines a guanidines functioning as protease inhibitors
AR034120A1 (en) * 2000-04-13 2004-02-04 Pharmacia Corp HALOGENATED DERIVATIVE COMPOUND OF HEPTENOIC ACID 2-AMINO-4,5, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOUND AND SUCH COMPOSITION IN THE MANUFACTURE OF A MEDICINAL PRODUCT TO INHIBIT OR MODULATE NITRIC ACID SYNTHESIS
ITTO20010110A1 (en) 2001-02-08 2002-08-08 Rotta Research Lab NEW BENZAMIDINE DERIVATIVES EQUIPPED WITH ANTI-INFLAMMATORY AND IMMUNOSOPPRESSIVE ACTIVITY.
RU2223952C2 (en) * 2001-06-04 2004-02-20 Институт физиологически активных веществ РАН Derivatives of n,s-substituted n'-1-[(hetero)aryl]-n'-[(hetero)aryl]- methylisothioureas or their salts and bases, pharmaceutical composition, method for treatment and method for study of glutamatergic system
DE60325959D1 (en) * 2002-05-09 2009-03-12 Baker Medical Res Inst Prahran Amino Acid Analogs
RU2252936C2 (en) * 2002-12-05 2005-05-27 Институт физиологически активных веществ РАН S-substituted [(hetero)aryl]alkylisothioureas, production thereof, pharmaceutical composition, investigation of glutamatergic system, treatment methods (variants)
WO2006054912A1 (en) * 2004-11-18 2006-05-26 Obchestvo S Ogranichennoy Otvetstvennost'u 'asineks Medhim' Aryl(hetaryl)-3-aminomethyl-quinilone-2 derivatives in the form of no-synthetase i and cyclooxygenase-2 nhibitors, methods for the production thereof and compositions based thereon
EP1917244A2 (en) 2005-08-24 2008-05-07 Abbott GmbH & Co. KG Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
IT1201511B (en) * 1985-12-23 1989-02-02 Italfarmaco Spa CITOPROTECTIVE DERIVATIVES IN ISCHEMIC-BASED DISEASES, THEIR PREPARATION AND COMPOSITIONS THAT CONTAIN THEM
US4992463A (en) * 1988-07-20 1991-02-12 Monsanto Company Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
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GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
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US5364884A (en) * 1993-01-21 1994-11-15 Baylor College Of Medicine Arginine compounds as ocular hypotensive agents
US5439938A (en) * 1993-04-07 1995-08-08 The Johns Hopkins University Treatments for male sexual dysfunction
US5424447A (en) * 1993-07-07 1995-06-13 The Medical College Of Wisconsin Research Foundation, Inc. Heme binding compounds and use thereof

Also Published As

Publication number Publication date
JPH09501651A (en) 1997-02-18
HUT73169A (en) 1996-06-28
US5874472A (en) 1999-02-23
AU6976394A (en) 1995-01-17
HU9501816D0 (en) 1995-08-28
ATE163932T1 (en) 1998-03-15
WO1995000505A1 (en) 1995-01-05
GB9312761D0 (en) 1993-08-04
DE69408988D1 (en) 1998-04-16
EP0705257B1 (en) 1998-03-11
DK0705257T3 (en) 1998-12-21
DE69408988T2 (en) 1998-07-30
EP0705257A1 (en) 1996-04-10

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