ES2109190A1 - Nuevos derivados de bencimidazol con afinidad por los receptores serotoninergicos 5-ht /5-ht - Google Patents
Nuevos derivados de bencimidazol con afinidad por los receptores serotoninergicos 5-ht /5-htInfo
- Publication number
- ES2109190A1 ES2109190A1 ES09600700A ES9600700A ES2109190A1 ES 2109190 A1 ES2109190 A1 ES 2109190A1 ES 09600700 A ES09600700 A ES 09600700A ES 9600700 A ES9600700 A ES 9600700A ES 2109190 A1 ES2109190 A1 ES 2109190A1
- Authority
- ES
- Spain
- Prior art keywords
- serotoninergic
- receptors
- affinity
- troubles
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NUEVOS DERIVADOS DE BENCIMIDAZOL CON AFINIDAD POR LOS RECEPTORES SEROTONINERGICOS 5-HT3/5-HT4. LA PRESENTE INVENCION TRATA DE NUEVOS COMPUESTOS DE FORMULA GENERAL I, DONDE X ES OXIGENO O NITROGENO; R ES HIDROGENO O CLORO; R'' ES HIDROGENO, NITRO O AMINO; E Y ES AZABICICLO [X.Y.Z] ALQUILO, N-ALQUILPIPERIDILO O DIALQUILAMINOALQUILO. SE DESCRIBEN LOS METODOS DE PREPARACION DE DICHOS COMPUESTOS, LOS CUALES HAN MOSTRADO UNA ELEVADA AFINIDAD POR LOS RECEPTORES SEROTONINERGICOS 5-HT3 Y/O 5-HT4, LO QUE INDICA SU INTERES DESDE EL PUNTO DE VISTA TERAPEUTICO EN EL TRATAMIENTO DE LA EMESIS PROVOCADA POR LA QUIMIOTERAPIA, Y EN EL TRATAMIENTO DE ALTERACIONES GASTROINTESTINALES Y NEURONALES, TALES COMO LA ANSIEDAD, LA PSICOSIS, LA DROGODEPENDENCIA Y LOS TRASTORNOS COGNITIVOS.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9600700A ES2109190B1 (es) | 1996-03-22 | 1996-03-22 | Nuevos derivados de bencimidazol con afinidad por los receptores serotoninergicos 5-ht /5-ht |
AU21607/97A AU2160797A (en) | 1996-03-22 | 1997-03-18 | Novel benzimidazol derivatives having an affinity for the serotoninergic 5-ht3/5 ht4 receptors |
PCT/ES1997/000068 WO1997035860A1 (es) | 1996-03-22 | 1997-03-18 | Nuevos derivados de bencimidazol con afinidad por los receptores serotoninergicos 5-ht3/5-ht¿4? |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9600700A ES2109190B1 (es) | 1996-03-22 | 1996-03-22 | Nuevos derivados de bencimidazol con afinidad por los receptores serotoninergicos 5-ht /5-ht |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2109190A1 true ES2109190A1 (es) | 1998-01-01 |
ES2109190B1 ES2109190B1 (es) | 1998-07-01 |
Family
ID=8294288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9600700A Expired - Fee Related ES2109190B1 (es) | 1996-03-22 | 1996-03-22 | Nuevos derivados de bencimidazol con afinidad por los receptores serotoninergicos 5-ht /5-ht |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2160797A (es) |
ES (1) | ES2109190B1 (es) |
WO (1) | WO1997035860A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7351732B2 (en) | 2002-07-31 | 2008-04-01 | Schwarz Pharma S.L. | Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2154605B1 (es) * | 1999-09-14 | 2001-11-16 | Univ Madrid Complutense | Nuevos derivados mixtos de bencimidazol-arilpiperazina con afinidad por los receptores serotoninergicos 5-ht1a y 5-ht3 |
AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
AR036041A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
HUP0402289A2 (hu) | 2001-10-02 | 2005-02-28 | Pharmacia & Upjohn Company | Gyógyhatású azabiciklusos csoporttal helyettesített kondenzált heteroaril-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
MXPA04004373A (es) | 2001-11-09 | 2004-08-11 | Upjohn Co | Compuestos heterociclicos condensados con fenilo azabiciclo para el tratamiento de enfermedades. |
US6858613B2 (en) | 2002-02-19 | 2005-02-22 | Pfizer Inc. | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease |
EP1476448A2 (en) | 2002-02-19 | 2004-11-17 | PHARMACIA & UPJOHN COMPANY | Azabicyclic compounds for the treatment of disease |
WO2005021040A2 (en) * | 2003-08-29 | 2005-03-10 | Dynogen Pharmaceuticals, Inc. | Compositions useful for treating gastrointestinal motility disorders |
TW200533348A (en) | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
US7728006B2 (en) | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
SE0401969D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Piperidine derivatives |
DE602005016446D1 (de) | 2004-11-05 | 2009-10-15 | Theravance Inc | 5-HT4-Rezeptoragonistenverbindungen |
DE602005014566D1 (de) | 2004-11-05 | 2009-07-02 | Theravance Inc | Chinolinon-carboxamid-verbindungen |
CA2588037A1 (en) | 2004-12-22 | 2006-06-29 | Theravance, Inc. | Indazole-carboxamide compounds |
BRPI0607748A2 (pt) | 2005-02-17 | 2017-05-23 | Amr Tech Inc | composto, composição farmacêutica, e, método de tratamento de um distúrbio |
NZ560828A (en) | 2005-03-02 | 2011-01-28 | Theravance Inc | Quinolinone compounds as 5-HT4 receptor agonists |
US7256294B2 (en) | 2005-05-25 | 2007-08-14 | Theravance, Inc. | Crystalline form of a benzimidazole-carboxamide medicinal compound |
MY147756A (en) | 2005-05-25 | 2013-01-15 | Theravance Inc | Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994000454A1 (en) * | 1992-06-24 | 1994-01-06 | G.D. Searle & Co. | Benzimidazole compounds |
WO1994000449A1 (en) * | 1992-06-24 | 1994-01-06 | G.D. Searle & Co. | Benzimidazole compounds |
WO1995003298A1 (en) * | 1993-07-19 | 1995-02-02 | Fujisawa Pharmaceutical Co., Ltd. | BENZIMIDAZOLE DERIVATIVES USEFUL AS DOPAMINE RECEPTOR ANTAGONIST, 5-HT RECEPTOR AGONIST OR α1 RECEPTOR ANTAGONIST |
-
1996
- 1996-03-22 ES ES9600700A patent/ES2109190B1/es not_active Expired - Fee Related
-
1997
- 1997-03-18 AU AU21607/97A patent/AU2160797A/en not_active Abandoned
- 1997-03-18 WO PCT/ES1997/000068 patent/WO1997035860A1/es active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994000454A1 (en) * | 1992-06-24 | 1994-01-06 | G.D. Searle & Co. | Benzimidazole compounds |
WO1994000449A1 (en) * | 1992-06-24 | 1994-01-06 | G.D. Searle & Co. | Benzimidazole compounds |
WO1995003298A1 (en) * | 1993-07-19 | 1995-02-02 | Fujisawa Pharmaceutical Co., Ltd. | BENZIMIDAZOLE DERIVATIVES USEFUL AS DOPAMINE RECEPTOR ANTAGONIST, 5-HT RECEPTOR AGONIST OR α1 RECEPTOR ANTAGONIST |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7351732B2 (en) | 2002-07-31 | 2008-04-01 | Schwarz Pharma S.L. | Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications |
Also Published As
Publication number | Publication date |
---|---|
WO1997035860A1 (es) | 1997-10-02 |
ES2109190B1 (es) | 1998-07-01 |
AU2160797A (en) | 1997-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19980101 Kind code of ref document: A1 Effective date: 19980101 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20160629 |