ES2105959A1 - Derivados de 1,4-dioxido de quinoxalina, procedimiento de preparacion y de utilizacion. - Google Patents

Derivados de 1,4-dioxido de quinoxalina, procedimiento de preparacion y de utilizacion.

Info

Publication number
ES2105959A1
ES2105959A1 ES09500076A ES9500076A ES2105959A1 ES 2105959 A1 ES2105959 A1 ES 2105959A1 ES 09500076 A ES09500076 A ES 09500076A ES 9500076 A ES9500076 A ES 9500076A ES 2105959 A1 ES2105959 A1 ES 2105959A1
Authority
ES
Spain
Prior art keywords
quinoxaline
cytotoxic
dioxides
vitro
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09500076A
Other languages
English (en)
Other versions
ES2105959B1 (es
Inventor
Vega Antonio Monge
Andy J Barker
Elizabeth Hamilton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
Original Assignee
Zeneca Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Pharma SA filed Critical Zeneca Pharma SA
Priority to ES9500076A priority Critical patent/ES2105959B1/es
Priority to GB9600963A priority patent/GB2297089B/en
Publication of ES2105959A1 publication Critical patent/ES2105959A1/es
Application granted granted Critical
Publication of ES2105959B1 publication Critical patent/ES2105959B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DERIVADOS DE 1,4-DIOXIDO DE QUINOXALINA, PROCEDIMIENTO DE PREPARACION Y DE UTILIZACION. DICHOS DERIVADOS RESPONDEN A LA FORMULA 1 EN DONDE LOS DISTINTOS RADICALES TIENEN LOS SIGNIFICADOS OFRECIDOS EN LA DESCRIPCION Y SE OBTIENEN MEDIANTE REACCION DE UN COMPUESTO DE FORMULA 3 CON UN COMPUESTO DE FORMULA NH2-ALQUIL (1-6C)-N(A1) (A2) EN DONDE A1 Y A2 TIENEN EL SIGNIFICADO INDICADO EN LA DESCRIPCION. LOS COMPUESTOS DE FORMULA 1 SON DE UTILIDAD COMO AGENTES CITOTOXICOS PARA DESTRUIR SELECTIVAMENTE CELULAS HIPOXICAS TUMORALES EN MAMIFEROS.
ES9500076A 1995-01-17 1995-01-17 Derivados de 1,4-dioxido de quinoxalina, procedimiento de preparacion y de utilizacion. Expired - Fee Related ES2105959B1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES9500076A ES2105959B1 (es) 1995-01-17 1995-01-17 Derivados de 1,4-dioxido de quinoxalina, procedimiento de preparacion y de utilizacion.
GB9600963A GB2297089B (en) 1995-01-17 1996-01-17 Derivatives of quinoxaline 1 4-dioxide procedure for their preparation and their employment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9500076A ES2105959B1 (es) 1995-01-17 1995-01-17 Derivados de 1,4-dioxido de quinoxalina, procedimiento de preparacion y de utilizacion.

Publications (2)

Publication Number Publication Date
ES2105959A1 true ES2105959A1 (es) 1997-10-16
ES2105959B1 ES2105959B1 (es) 1998-07-01

Family

ID=8289176

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9500076A Expired - Fee Related ES2105959B1 (es) 1995-01-17 1995-01-17 Derivados de 1,4-dioxido de quinoxalina, procedimiento de preparacion y de utilizacion.

Country Status (2)

Country Link
ES (1) ES2105959B1 (es)
GB (1) GB2297089B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2278244A1 (en) * 1997-01-21 1998-07-23 Nissan Chemical Industries, Ltd. Industrial antimicrobial/mildew-proofing agents, algicides and antifouling agents containing n-quinoxalylanilines
ATE261963T1 (de) 1999-01-11 2004-04-15 Agouron Pharma Tricyclische inhibitoren von poly(adp-ribose) polymerasen
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
DE60228134D1 (de) 2001-12-10 2008-09-18 Univ Temple Substituierte hydrazone als hemmer von cyclooxygenase-2
JP2006241111A (ja) * 2005-03-04 2006-09-14 Univ Nihon 新規ベンゾフロキサン及びその合成法
US7968713B2 (en) * 2005-10-14 2011-06-28 Nihon University Method of synthesizing quinoxaline derivative by microwave irradiation
WO2015167350A1 (ru) 2014-04-28 2015-11-05 Общество С Ограниченной Ответственностью "А-Лаборатория" Способ лечения опухолевого заболевания и способ селективного ингибирования роста опухолевых клеток с помощью производного хиноксалин-1,4-диоксида

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343942A (en) * 1966-11-08 1982-08-10 Research Corporation Quinoxaline derivatives
EP0289752A1 (en) * 1987-04-13 1988-11-09 The Firestone Tire & Rubber Company Rubber compositions modified with heterocyclic Di-N-oxides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343942A (en) * 1966-11-08 1982-08-10 Research Corporation Quinoxaline derivatives
EP0289752A1 (en) * 1987-04-13 1988-11-09 The Firestone Tire & Rubber Company Rubber compositions modified with heterocyclic Di-N-oxides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
K. LEY y F. SENG. Synthesen unter Verwendung von Benzofuroxan. Synthesis, Abril 1975, pßginas 415-422 * Pßgina 417, tabla 2, ·ltimo R3 * *
MONGE, A y col. New Quinoxaline and Pyrimido[4,5-b]quinoxaline Derivatives. Potential Antihypertensive and Blood Platelet Antiaggregating Agents. J. Heterocyclic Chem, 1989, Vol. 26, N‘ 6, pßginas 1623-6 *

Also Published As

Publication number Publication date
ES2105959B1 (es) 1998-07-01
GB2297089A (en) 1996-07-24
GB9600963D0 (en) 1996-03-20
GB2297089B (en) 1998-08-26

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