ES2102466T3 - Nuevos compuestos denominados adenofostinas; su preparacion y su uso terapeutico. - Google Patents

Nuevos compuestos denominados adenofostinas; su preparacion y su uso terapeutico.

Info

Publication number
ES2102466T3
ES2102466T3 ES92307387T ES92307387T ES2102466T3 ES 2102466 T3 ES2102466 T3 ES 2102466T3 ES 92307387 T ES92307387 T ES 92307387T ES 92307387 T ES92307387 T ES 92307387T ES 2102466 T3 ES2102466 T3 ES 2102466T3
Authority
ES
Spain
Prior art keywords
adenofostinas
preparation
therapeutic use
new compounds
compounds called
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92307387T
Other languages
English (en)
Inventor
Shuji Takahashi
Masaaki Takahashi
Kazuhiko Tanzawa
Kaneo Ogawa
Tsuyoshi Hosoya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2102466T3 publication Critical patent/ES2102466T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I): (EN LA QUE R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ACETIL), QUE SE HAN DENOMINADO "ADENOFOSTINAS", ASI COMO LAS SALES Y ESTERES DE LOS MISMOS, LOS COMPUESTOS TIENEN LA CAPACIDAD DE INCREMENTAR LAS CONCENTRACIONES DE IONES DE CALCIO INTRACELULAR MEDIANTE LA ACTUACION SOBRE LOS RECEPTORES DEL 1,4,5-TRIFOSFATO DE INOSITOL (INSP3) QUE EXISTE EN EL RETICULO ENDOPLASMICO, Y PUEDEN ADEMAS USARSE PARA EL TRATAMIENTO O PROFILAXIS DE ENFERMEDADES CEREBRALES. LOS COMPUESTOS PUEDEN PREPARARSE MEDIANTE EL CULTIVO DE UN MICROORGANISMO DE GENERO "PENECILLIUM", POR EJEMPLO PENICILLIUM BREVICOMPACTUM" SANK 11991 (FERM BP-3499) O PENICILLIUM BREVICOMPACTUM SANK 12177 (FERM BP-3500).
ES92307387T 1991-08-14 1992-08-12 Nuevos compuestos denominados adenofostinas; su preparacion y su uso terapeutico. Expired - Lifetime ES2102466T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20408991 1991-08-14

Publications (1)

Publication Number Publication Date
ES2102466T3 true ES2102466T3 (es) 1997-08-01

Family

ID=16484606

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92307387T Expired - Lifetime ES2102466T3 (es) 1991-08-14 1992-08-12 Nuevos compuestos denominados adenofostinas; su preparacion y su uso terapeutico.

Country Status (10)

Country Link
US (1) US5436231A (es)
EP (1) EP0527646B1 (es)
JP (1) JP2750239B2 (es)
AT (1) ATE150762T1 (es)
CA (1) CA2076060C (es)
DE (1) DE69218517T2 (es)
DK (1) DK0527646T3 (es)
ES (1) ES2102466T3 (es)
GR (1) GR3023824T3 (es)
HK (1) HK1005737A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1097713A1 (en) 1999-11-03 2001-05-09 Euroscreen S.A. Inhibitors of the inositol polyphosphate 5-phosphatase ship-2 molecule

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2509531A1 (de) * 1975-03-05 1976-09-16 Thomae Gmbh Dr K Antivirales mittel
EP0249873B1 (en) * 1986-06-16 1993-07-28 Daiichi Pharmaceutical Co., Ltd. Therapeutic agent for skin ulcers
US5049550A (en) * 1987-11-05 1991-09-17 Worcester Foundation For Experimental Biology Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents
JPH01308231A (ja) * 1988-06-03 1989-12-12 Takeda Chem Ind Ltd 安定化された医薬組成物および製造法
SE464059C (sv) * 1988-09-15 1997-06-02 Perstorp Ab Användning av inositoltrifosfat för framställning av läkemedel

Also Published As

Publication number Publication date
GR3023824T3 (en) 1997-09-30
JPH05194580A (ja) 1993-08-03
DE69218517T2 (de) 1997-11-13
JP2750239B2 (ja) 1998-05-13
CA2076060C (en) 2002-08-06
DE69218517D1 (de) 1997-04-30
CA2076060A1 (en) 1993-02-15
HK1005737A1 (en) 1999-01-22
US5436231A (en) 1995-07-25
ATE150762T1 (de) 1997-04-15
DK0527646T3 (da) 1997-10-13
EP0527646B1 (en) 1997-03-26
EP0527646A1 (en) 1993-02-17

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