ES2099419T3 - COLD SPRAY NABUMETONE. - Google Patents

COLD SPRAY NABUMETONE.

Info

Publication number
ES2099419T3
ES2099419T3 ES93902444T ES93902444T ES2099419T3 ES 2099419 T3 ES2099419 T3 ES 2099419T3 ES 93902444 T ES93902444 T ES 93902444T ES 93902444 T ES93902444 T ES 93902444T ES 2099419 T3 ES2099419 T3 ES 2099419T3
Authority
ES
Spain
Prior art keywords
pct
nabumetone
cold spray
sec
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902444T
Other languages
Spanish (es)
Inventor
Graham Stanley Leonard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2099419T3 publication Critical patent/ES2099419T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coating By Spraying Or Casting (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Road Signs Or Road Markings (AREA)
  • Catching Or Destruction (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PCT No. PCT/GB93/00145 Sec. 371 Date Feb. 22, 1993 Sec. 102(e) Date Feb. 22, 1993 PCT Filed Jan. 22, 1993 PCT Pub. No. WO93/14747 PCT Pub. Date Aug. 5, 1993Nabumetone which is spray-chilled and formulated into unit dose forms which have a smaller volume than was previously possible.
ES93902444T 1992-01-29 1993-01-22 COLD SPRAY NABUMETONE. Expired - Lifetime ES2099419T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929201857A GB9201857D0 (en) 1992-01-29 1992-01-29 Novel compound

Publications (1)

Publication Number Publication Date
ES2099419T3 true ES2099419T3 (en) 1997-05-16

Family

ID=10709436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902444T Expired - Lifetime ES2099419T3 (en) 1992-01-29 1993-01-22 COLD SPRAY NABUMETONE.

Country Status (24)

Country Link
US (1) US5539000A (en)
EP (1) EP0624087B1 (en)
JP (1) JPH07503245A (en)
KR (1) KR950700056A (en)
CN (1) CN1079954A (en)
AT (1) ATE150298T1 (en)
AU (1) AU3362693A (en)
BG (1) BG98933A (en)
BR (1) BR9305674A (en)
CA (1) CA2129027A1 (en)
CZ (1) CZ182894A3 (en)
DE (1) DE69309037T2 (en)
DK (1) DK0624087T3 (en)
ES (1) ES2099419T3 (en)
FI (1) FI943550A (en)
GB (1) GB9201857D0 (en)
GR (1) GR3023142T3 (en)
HU (1) HUT67462A (en)
IL (1) IL104526A0 (en)
MX (1) MX9300430A (en)
NO (1) NO942813L (en)
SK (1) SK91694A3 (en)
WO (1) WO1993014747A1 (en)
ZA (1) ZA93577B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
GB9920148D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel composition
TWI262791B (en) 1999-10-27 2006-10-01 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
US6436990B1 (en) 1999-10-27 2002-08-20 Nobex Corporation 6-methoxy-2-naphthylacetic acid prodrugs
US6552078B2 (en) 1999-10-27 2003-04-22 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
US20020132010A1 (en) * 2000-12-22 2002-09-19 Yihong Qui Divalproex sodium dosage forms and a process for their production
US20040161474A1 (en) * 2002-05-24 2004-08-19 Moerck Rudi E. Rare earth metal compounds methods of making, and methods of using the same
US20060083791A1 (en) * 2002-05-24 2006-04-20 Moerck Rudi E Rare earth metal compounds methods of making, and methods of using the same
US20040115287A1 (en) * 2002-12-17 2004-06-17 Lipocine, Inc. Hydrophobic active agent compositions and methods
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
CA2547774A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Method for making pharmaceutical multiparticulates
RU2006119453A (en) * 2003-12-04 2007-12-20 Пфайзер Продактс Инк. (Us) PRODUCTION OF MEDICINES ASITROMYCIN WITH A LARGE NUMBER OF PARTICLES BASED ON THE APPLICATION OF LIQUIDS OF METHODS
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
WO2005053656A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
KR20080064209A (en) * 2003-12-04 2008-07-08 화이자 프로덕츠 인코포레이티드 Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride
JP2008516971A (en) * 2004-10-15 2008-05-22 アルテアーナノ，インコーポレーテッド Phosphate binder that reduces the burden of tablets
JP2009504779A (en) * 2005-08-17 2009-02-05 アルテアナノ インコーポレイテッド Treatment of chronic renal failure and other illnesses in livestock: compositions and methods
US7541384B2 (en) * 2007-06-08 2009-06-02 Axcan Pharma Inc. Mesalamine suppository
US8217083B2 (en) * 2007-06-08 2012-07-10 Aptalis Pharma Canada Inc. Mesalamine suppository
US8436051B2 (en) 2007-06-08 2013-05-07 Aptalis Pharma Canada Inc. Mesalamine suppository
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
KR101830456B1 (en) 2010-05-12 2018-02-20 스펙트럼 파마슈티컬즈 인크 Lanthanum carbonate hydroxide, lanthanum oxycarbonate and methods of their manufacture and use
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1474377A (en) 1973-09-11 1977-05-25 Beecham Group Ltd Naphthalene derivatives
US4420639C1 (en) * 1973-09-11 2001-08-21 Beecham Group Ltd Aromatic compounds
US4086346A (en) * 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
DE3833446A1 (en) 1988-10-01 1990-04-05 Hoechst Ag METHOD FOR THE PRODUCTION OF MEDICAMENT PARTICLES WITH IMPROVED FLUID, STORAGE AND FORMULATION PROPERTIES AND MEDICAMENTS CONTAINING SUCH MEDICAMENT PARTICLES

Also Published As

Publication number Publication date
DE69309037T2 (en) 1997-07-24
CA2129027A1 (en) 1993-08-05
NO942813D0 (en) 1994-07-28
KR950700056A (en) 1995-01-16
FI943550A0 (en) 1994-07-28
US5539000A (en) 1996-07-23
CN1079954A (en) 1993-12-29
AU3362693A (en) 1993-09-01
IL104526A0 (en) 1993-05-13
FI943550A (en) 1994-07-28
EP0624087A1 (en) 1994-11-17
HU9402221D0 (en) 1994-09-28
WO1993014747A1 (en) 1993-08-05
BR9305674A (en) 2005-01-11
MX9300430A (en) 1994-08-31
CZ182894A3 (en) 1995-02-15
SK91694A3 (en) 1995-03-08
ATE150298T1 (en) 1997-04-15
DE69309037D1 (en) 1997-04-24
HUT67462A (en) 1995-04-28
EP0624087B1 (en) 1997-03-19
DK0624087T3 (en) 1997-09-01
JPH07503245A (en) 1995-04-06
ZA93577B (en) 1994-01-13
GB9201857D0 (en) 1992-03-18
GR3023142T3 (en) 1997-07-30
NO942813L (en) 1994-07-28
BG98933A (en) 1995-07-28

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