ES2097080B1 - PROCEDURE FOR THE CONVERSION OF CEPHALOSPORIN C IN GLUTARIL-7-AMINOCEPHALOSPORANIC ACID. - Google Patents

PROCEDURE FOR THE CONVERSION OF CEPHALOSPORIN C IN GLUTARIL-7-AMINOCEPHALOSPORANIC ACID.

Info

Publication number
ES2097080B1
ES2097080B1 ES09400434A ES9400434A ES2097080B1 ES 2097080 B1 ES2097080 B1 ES 2097080B1 ES 09400434 A ES09400434 A ES 09400434A ES 9400434 A ES9400434 A ES 9400434A ES 2097080 B1 ES2097080 B1 ES 2097080B1
Authority
ES
Spain
Prior art keywords
glutaril
procedure
cephalosporin
aca
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09400434A
Other languages
Spanish (es)
Other versions
ES2097080A1 (en
Inventor
Kenji Matsuyama
Satoshi Soga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Publication of ES2097080A1 publication Critical patent/ES2097080A1/en
Application granted granted Critical
Publication of ES2097080B1 publication Critical patent/ES2097080B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA CONVERSION DE CEFALOSPORINA C EN ACIDO GLUTARIL-7-AMINOCEFALOSPORANICO. LA INVENCION SE REFIERE A UN PROCESO MEJORADO DE OXIDACION ENZIMATICA PARA CONVERTIR LA CEFALOSPORINA C EN ACIDO GLUTARIL-7-AMINOCEFALOSPORANICO (DESIGNADO A CONTINUACION GLUTARIL-7-ACA) QUE COMPRENDE EL ESTABLECER CONTACTO DE UNA SOLUCION ACUOSA DE CEFALOSPORINA C CON UNA MEZCLA QUE CONTIENE OXILDASA DE D-AMINOACIDO; EN EL QUE LA MEZCLA QUE CONTIENE OXIDASA DE D-AMINOACIDO ES OBTENIDA A PARTIR DE UN MICROORGANISMO MUTANTE DE CVATRIGONOPSIS VARIABILIS, CUYO MUTANTE MUESTRA 5 POR CIENTO O MENOS DE ACTIVIDAD ESTERASA BASADA EN SU ACTIVIDAD OXIDASA DE D-AMINOACIDO Y DERIVANDOSE DE CELULAS DE CVATRIGONOPSIS VARIABILIS CAPACES DE PRODUCIR OXIDASA DE D-AMINOACIDO. DE ACUERDO CON EL PROCEDIMIENTO DE LA PRESENTE INVENCION, NO TIENE LUGAR LA PRODUCCION DE FORMAS 3-DESACETILO DE CEFALOSPORINA C, GLUTARIL-7-ACA, Y EL INTERMEDIARIO AL-CETO ADIPOIL-7-ACA, DE MANERA QUE SE PUEDE OBTENER, CON ELEVADA CALIDAD, UNEXCELENTE RENDIMIENTO DE GLUTARIL-7-ACA. ADEMAS, EL PROCEDIMIENTO DE LA PRESENTE INVENCION COMPRENDE FASES SIMPLES Y SEGURAS, SIN NECESIDAD DE UTILIZAR UN DISOLVENTE, TAL COMO ACETONA, PARA EVITAR LA PRODUCCION DE FORMAS 3-DESACETILO, POR LO QUE ES APLICABLE A ESCALA INDUSTRIAL.PROCEDURE FOR THE CONVERSION OF CEPHALOSPORIN C IN GLUTARIL-7-AMINOCEPHALOSPORANIC ACID. THE INVENTION IS RELATED TO AN IMPROVED ENZYMATIC OXIDATION PROCESS TO CONVERT CEPHALOSPORIN C INTO GLUTARIL-7-AMINOCEPHALOSPORANIC ACID (DESIGNATED BELOW GLUTARIL-7-ACA) WHICH COMPLIES WITH THE ESTAUCTION OF A SOLUKAU CONTACT D-AMINO ACID OXYLDASE; IN WHICH THE MIXTURE CONTAINING D-AMINO ACID OXIDASE IS OBTAINED FROM A MUTANT MICROORGANISM OF CVATRIGONOPSIS VARIABILIS, WHOSE MUTANT SHOWS 5 PERCENT OR LESS OF ESTERASA ACTIVITY DURING YIVA DEUR-DIVA VARIABILIS CAPABLE OF PRODUCING D-AMINO ACID OXIDASE. PURSUANT TO THE PROCEDURE OF THE PRESENT INVENTION, THE PRODUCTION OF 3-DESACETILE FORMS OF CEPHALOSPORIN C, GLUTARIL-7-ACA, AND THE INTERMEDIARY AL-CETO ADIPOIL-7-ACA, THERE IS NO PLACE, SO THAT IT CAN BE OBTAINED, WITH HIGH QUALITY, EXCELLENT PERFORMANCE OF GLUTARIL-7-ACA. FURTHER, THE PROCEDURE OF THE PRESENT INVENTION INCLUDES SIMPLE AND SAFE PHASES, WITHOUT THE NEED TO USE A SOLVENT, SUCH AS ACETONE, TO AVOID THE PRODUCTION OF 3-DESACETILE FORMS, SO IT IS APPLICABLE ON AN INDUSTRIAL SCALE.

ES09400434A 1993-03-08 1994-03-03 PROCEDURE FOR THE CONVERSION OF CEPHALOSPORIN C IN GLUTARIL-7-AMINOCEPHALOSPORANIC ACID. Expired - Fee Related ES2097080B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7072793 1993-03-08

Publications (2)

Publication Number Publication Date
ES2097080A1 ES2097080A1 (en) 1997-03-16
ES2097080B1 true ES2097080B1 (en) 1997-11-16

Family

ID=13439867

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09400434A Expired - Fee Related ES2097080B1 (en) 1993-03-08 1994-03-03 PROCEDURE FOR THE CONVERSION OF CEPHALOSPORIN C IN GLUTARIL-7-AMINOCEPHALOSPORANIC ACID.

Country Status (7)

Country Link
JP (1) JPH06315396A (en)
AT (1) AT401269B (en)
DE (1) DE4407699C2 (en)
ES (1) ES2097080B1 (en)
FR (1) FR2702493B1 (en)
GB (1) GB2275925B (en)
IT (1) IT1269301B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0991752A2 (en) 1997-09-09 2000-04-12 Biochemie Gesellschaft M.B.H. Esterase free enzymes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
GB1385685A (en) * 1971-04-21 1975-02-26 Glaxo Lab Ltd Cephalosporin derivatives
EP0465600B1 (en) * 1989-04-04 1995-06-07 Biopure Corporation Enzymatic production of 7-amino cephalosporanic acid
DE69022909T2 (en) * 1989-07-19 1996-04-11 Lilly Co Eli Enzymatic oxidation of Ceph C to glutaryl-7-aminocephalosporanic acid.
DE4028119C1 (en) * 1990-09-05 1991-12-05 Hoechst Ag, 6230 Frankfurt, De
IT1252308B (en) * 1990-12-21 1995-06-08 Antibioticos Spa ENZYMATIC PROCEDURE FOR THE PRODUCTION OF 7- AMINOCEPHALOSPORANIC ACID AND DERIVATIVES
CA2100987C (en) * 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase

Also Published As

Publication number Publication date
ITMI940418A1 (en) 1995-09-08
DE4407699C2 (en) 2003-12-18
ES2097080A1 (en) 1997-03-16
GB2275925A (en) 1994-09-14
ATA47694A (en) 1995-12-15
GB2275925B (en) 1996-08-14
FR2702493A1 (en) 1994-09-16
JPH06315396A (en) 1994-11-15
AT401269B (en) 1996-07-25
IT1269301B (en) 1997-03-26
DE4407699A1 (en) 1994-09-15
ITMI940418A0 (en) 1994-03-08
FR2702493B1 (en) 1996-02-02
GB9404103D0 (en) 1994-04-20

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