ES2095277T3 - 6,7-dihidro-3-fenil-1,2-benzoisoxazol-4(5h)-onas y -oles, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents

6,7-dihidro-3-fenil-1,2-benzoisoxazol-4(5h)-onas y -oles, un procedimiento para su preparacion y su uso como medicamentos.

Info

Publication number
ES2095277T3
ES2095277T3 ES91113867T ES91113867T ES2095277T3 ES 2095277 T3 ES2095277 T3 ES 2095277T3 ES 91113867 T ES91113867 T ES 91113867T ES 91113867 T ES91113867 T ES 91113867T ES 2095277 T3 ES2095277 T3 ES 2095277T3
Authority
ES
Spain
Prior art keywords
chem
formula
loweralkyl
hydrogen
arylloweralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91113867T
Other languages
English (en)
Inventor
David Gordon Wettlaufer
Gregory Michael Shutske
Peter Allen Nemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2095277T3 publication Critical patent/ES2095277T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE AL 6, 7-DIHIDRO-3-FENILO-1, 2-BENZISOXAZOL -4(5H)-ONAS Y OLES DE LA FORMULA: DONDE X ES O UN ALCALINO BAJO; Y ES HIDROGENO, HALOGENO, ALCALINO BAJO, ALKOXI BAJO, TRIFLUOROMETILO, NITRO O AMINO; R ES H CUANDO LA UNION ENTRE EL ATOMO DE OXIGENO Y EL DE CARBONO ES CUESTION ES UNA UNION SIMPLE; SI NO LA LINEA PUNTEADA INDICA LA PARTE DE UNA UNION DOBLE AL ATOMO DE OXIGENO; R SUB 1 ES HIDROGENO, ALCALINO BAJO O UN ARIL BAJO ALCALINO; R SUB 2 Y R SUB 3 SON INDEPENDIENTEMENTE HIDROGENO, ALCALINO BAJO O ARIL BAJO ALCALINO, O R SUB 2 Y R SUB 3 TOMADOS CONJUNTAMENTE CON EL ATOMO DE NITROGENO FORMAN UN HETEROCICLICO SUSTITUIDO OPCIONALMENTE SELECCIONADO DEL GRUPO QUE CONSISTE EN PIPERIDINILO, PIRROLIDINILO, MORFOLINILO, IMIDAZOL-1-ILO, 1-PIPERAZINILO, DICHOS SUSTITUYENTES SON HIDROGENO O ALCALINO BAJO; 4-SUSTITUTO-1-PIPERAZINILO DE LA FORMULA: DONDE R SUB 6 ES UN ALCALINO BAJO, ARIL, ARIL BAJO ALCALINO, 2-PIRIMIDILO, 2-PIRIMIDILO DE LA FORMULA O 4-PIRIMIDILO DE LA FORMULA 4-SUSTITUIDO-1-PIERIDINILO DE LA FORMULA DONDE R SUB 7 ES HIDROGENO, ALCALINO BAJO, ARIL, ARIL BAJO ALCALINO, 2-PIRIDINILO DE LA FORMULA 4-PIRIDINILO DE LA FORMULA 2-PIRIDINILO DE LA FORMULA ARILCARBONILO R SUB 8 ES HIDROGENO O -OH; R SUB 4 ES HIDROGENO, ALKOXI BAJO CARBONILO O ARILOXICARBONILO; Z ES CLORO, BROMO O FLUORO; M ES UN ENTERO DE 1 A 4; N ES UN ENTERO DE 1 A 4 O UNA SAL CON ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE DEL MISMO Y DONDE SE APLICAN LOS ISOMEROS GEOMETRICOS Y OPTICOS Y LAS MEZCLAS RACEMICAS DEL MISMO. LOS COMPUESTOS DE ESTA INVENCION EXHIBEN SU UTILIDAD COMO AGENTES ANTIPSICOTICOS Y ANALGESICOS.
ES91113867T 1990-08-23 1991-08-19 6,7-dihidro-3-fenil-1,2-benzoisoxazol-4(5h)-onas y -oles, un procedimiento para su preparacion y su uso como medicamentos. Expired - Lifetime ES2095277T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57148290A 1990-08-23 1990-08-23
US07/692,341 US5114936A (en) 1990-08-23 1991-04-26 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use

Publications (1)

Publication Number Publication Date
ES2095277T3 true ES2095277T3 (es) 1997-02-16

Family

ID=27075593

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91113867T Expired - Lifetime ES2095277T3 (es) 1990-08-23 1991-08-19 6,7-dihidro-3-fenil-1,2-benzoisoxazol-4(5h)-onas y -oles, un procedimiento para su preparacion y su uso como medicamentos.

Country Status (20)

Country Link
US (1) US5114936A (es)
EP (1) EP0474012B1 (es)
JP (1) JP3018619B2 (es)
KR (1) KR0173685B1 (es)
AT (1) ATE145644T1 (es)
AU (1) AU634944B2 (es)
CA (1) CA2049733C (es)
CS (1) CS260191A3 (es)
DE (1) DE69123315T2 (es)
DK (1) DK0474012T3 (es)
ES (1) ES2095277T3 (es)
FI (1) FI913957A (es)
GR (1) GR3022697T3 (es)
HU (1) HU215439B (es)
IE (1) IE76138B1 (es)
IL (1) IL99264A (es)
NO (1) NO913292L (es)
NZ (1) NZ239494A (es)
PT (1) PT98747B (es)
YU (1) YU142991A (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114960A (en) * 1989-07-20 1992-05-19 Hoffmann-La Roche Inc. Substituted isoxazole derivatives
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
US5225412A (en) * 1991-04-29 1993-07-06 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
GB2264299B (en) * 1992-02-19 1995-07-26 British Tech Group Iso-oxazolidine derivatives
GB9226857D0 (en) * 1992-12-23 1993-02-17 Boyd Edward A Pharmaceutical compositions
GB2284600A (en) * 1994-01-21 1995-06-14 Shell Int Research Herbicidal 3-(hetero)aryl-4-acylisoxazole compositions and compounds
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
AU7479400A (en) * 1999-09-14 2001-04-17 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4 antagonists
EP1484325B1 (en) 2002-03-08 2014-06-18 Japan Science and Technology Agency Isoxazole derivatives and process for producing the same
US6770659B2 (en) 2002-08-26 2004-08-03 Sk Corporation Benzoyl piperidine compounds
CA3170247A1 (en) * 2012-09-14 2014-03-20 Supernus Pharmaceuticals Inc. Methods of producing molindone and its salts
US10745401B2 (en) 2018-07-23 2020-08-18 Sumitomo Dainippon Pharma Co., Ltd. Condensed lactam derivative
CA3105428A1 (en) * 2018-07-23 2020-01-30 Sumitomo Dainippon Pharma Co., Ltd. Condensed lactam derivative
KR102453994B1 (ko) * 2020-04-10 2022-10-14 용효중 가정용 아쿠아포닉스 장치
KR102639474B1 (ko) * 2021-10-28 2024-02-22 박정한 수조 테이블
WO2023083445A1 (en) 2021-11-10 2023-05-19 Symrise Ag Compositions comprising trpm8 agonistic cooling agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4010176A (en) * 1972-10-27 1977-03-01 Merck & Co., Inc. Isoxazole substituted nitroimidazoles
US4217349A (en) * 1974-07-01 1980-08-12 Sumitomo Chemical Company, Limited Benzisoxazole derivatives
US4156005A (en) * 1978-06-21 1979-05-22 Merck & Co., Inc. Derivatives of 1,2-benzisoxazoles
GB2024008B (en) * 1978-06-28 1983-02-16 Merck & Co Inc Compositions for treating trypanosomiasis infections
EP0149229B1 (en) * 1981-04-27 1989-06-14 Hoechst-Roussel Pharmaceuticals Incorporated 3-(gamma-chloropropyl)-6-fluor-1,2-benzisoxazole, process for its preparation and its use as an intermediate
IL66866A (en) * 1982-04-09 1987-08-31 Hoechst Roussel Pharma 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them
US4458075A (en) * 1982-04-09 1984-07-03 Hoechst-Roussel Pharmaceuticals Inc. 6-Fluoro-3-[3-(1-heterocyclo)propyl]-1,2-benzisoxazoles
ATE81975T1 (de) * 1984-12-21 1992-11-15 Duphar Int Res Arzneimittel mit psychotroper wirkung.
HU208690B (en) * 1987-10-26 1993-12-28 Pfizer Process for producing 1-hjeterocyclic sulfonyl-3-(pyrimidinyl piperazinyl)-propane derivatives and pharmaceutical compositions comprising same
US5114960A (en) * 1989-07-20 1992-05-19 Hoffmann-La Roche Inc. Substituted isoxazole derivatives

Also Published As

Publication number Publication date
DE69123315T2 (de) 1997-05-22
FI913957A (fi) 1992-02-24
NZ239494A (en) 1994-08-26
CA2049733C (en) 2003-10-21
EP0474012B1 (en) 1996-11-27
IL99264A0 (en) 1992-07-15
PT98747A (pt) 1992-07-31
AU634944B2 (en) 1993-03-04
IE912976A1 (en) 1992-02-26
HUT61533A (en) 1993-01-28
HU215439B (hu) 1999-09-28
DK0474012T3 (da) 1997-05-12
GR3022697T3 (en) 1997-05-31
IE76138B1 (en) 1997-10-08
ATE145644T1 (de) 1996-12-15
AU8261791A (en) 1991-11-07
DE69123315D1 (de) 1997-01-09
JPH04230673A (ja) 1992-08-19
PT98747B (pt) 1999-01-29
EP0474012A1 (en) 1992-03-11
KR0173685B1 (ko) 1999-02-01
JP3018619B2 (ja) 2000-03-13
US5114936A (en) 1992-05-19
CS260191A3 (en) 1992-04-15
FI913957A0 (fi) 1991-08-21
KR920004366A (ko) 1992-03-27
HU912756D0 (en) 1992-01-28
IL99264A (en) 1996-01-19
NO913292L (no) 1992-02-24
CA2049733A1 (en) 1992-02-24
YU142991A (sh) 1995-01-31
NO913292D0 (no) 1991-08-22

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