ES2094885T3 - Unas composiciones de materia en la forma de 1-alquil-2-acil-1,2-disulfonil hidracinas y su uso. - Google Patents
Unas composiciones de materia en la forma de 1-alquil-2-acil-1,2-disulfonil hidracinas y su uso.Info
- Publication number
- ES2094885T3 ES2094885T3 ES92310041T ES92310041T ES2094885T3 ES 2094885 T3 ES2094885 T3 ES 2094885T3 ES 92310041 T ES92310041 T ES 92310041T ES 92310041 T ES92310041 T ES 92310041T ES 2094885 T3 ES2094885 T3 ES 2094885T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- disulfonil
- acil
- hydrazines
- material compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCRIBE UNA NUEVA 1-ALQUIL-2-ACIL-1,2-DISULFONILHIDRAZINA ANTINEOPLASTICA QUE TIENE LA FORMULA: JUNTO CON METODOS DE TERAPIA QUE UTILIZAN ESOS COMPUESTOS ANTINEOPLASTICOS. R1 Y R2 SON (INDEPENDIENTEMENTE) ALQUILO, CICLOALQUILO, ARILO, ARALQUILO O HETEROARILO. X ES UN GRUPO ACILO Y Z ES UN ALQUILO O UN GRUPO HALOALQUILO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/790,689 US5256820A (en) | 1991-11-08 | 1991-11-08 | 1-alkyl-2-acyl-1,2-disulfonylhydrazines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2094885T3 true ES2094885T3 (es) | 1997-02-01 |
Family
ID=25151476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92310041T Expired - Lifetime ES2094885T3 (es) | 1991-11-08 | 1992-11-02 | Unas composiciones de materia en la forma de 1-alquil-2-acil-1,2-disulfonil hidracinas y su uso. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5256820A (es) |
EP (1) | EP0541322B1 (es) |
JP (1) | JP3229039B2 (es) |
AT (1) | ATE142620T1 (es) |
CA (1) | CA2082037A1 (es) |
DE (1) | DE69213656T2 (es) |
DK (1) | DK0541322T3 (es) |
ES (1) | ES2094885T3 (es) |
GR (1) | GR3021045T3 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5637619A (en) * | 1995-07-05 | 1997-06-10 | Yale University | Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines |
US6040338A (en) * | 1997-11-03 | 2000-03-21 | Yale University | N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents |
WO2004098504A2 (en) * | 2003-04-30 | 2004-11-18 | Yale University | Antitumor 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines and methods of treating tumors |
US6855695B2 (en) * | 2003-06-13 | 2005-02-15 | Vion Pharmaceuticals, Inc. | Water-soluble SHPs as novel alkylating agents |
US7605137B2 (en) * | 2004-03-26 | 2009-10-20 | Vion Pharmaceuticals, Inc. | Combination therapy comprising cloretazine |
JP4814245B2 (ja) * | 2004-09-21 | 2011-11-16 | ヴァイオン ファーマシューティカルズ、インコーポレーテッド | 低酸素選択性抗腫瘍剤としてのスルホニルヒドラジンのリン酸含有プロドラッグ |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4892887A (en) * | 1984-12-20 | 1990-01-09 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
US4684747A (en) * | 1984-12-20 | 1987-08-04 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
US4849563A (en) * | 1986-01-21 | 1989-07-18 | Yale University | Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
US5101072A (en) * | 1989-09-06 | 1992-03-31 | Yale University | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents |
-
1991
- 1991-11-08 US US07/790,689 patent/US5256820A/en not_active Expired - Lifetime
-
1992
- 1992-11-02 ES ES92310041T patent/ES2094885T3/es not_active Expired - Lifetime
- 1992-11-02 DK DK92310041.6T patent/DK0541322T3/da active
- 1992-11-02 AT AT92310041T patent/ATE142620T1/de not_active IP Right Cessation
- 1992-11-02 DE DE69213656T patent/DE69213656T2/de not_active Expired - Fee Related
- 1992-11-02 EP EP92310041A patent/EP0541322B1/en not_active Expired - Lifetime
- 1992-11-03 CA CA002082037A patent/CA2082037A1/en not_active Abandoned
- 1992-11-06 JP JP29737492A patent/JP3229039B2/ja not_active Expired - Fee Related
-
1996
- 1996-09-13 GR GR960402407T patent/GR3021045T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0541322A1 (en) | 1993-05-12 |
GR3021045T3 (en) | 1996-12-31 |
DE69213656T2 (de) | 1997-01-23 |
CA2082037A1 (en) | 1993-05-09 |
EP0541322B1 (en) | 1996-09-11 |
DK0541322T3 (da) | 1996-10-14 |
ATE142620T1 (de) | 1996-09-15 |
JPH0625146A (ja) | 1994-02-01 |
US5256820A (en) | 1993-10-26 |
JP3229039B2 (ja) | 2001-11-12 |
DE69213656D1 (de) | 1996-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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