ES2087915T3 - Agente terapeutico y procedimiento que inhibe la vascularizacion de tumores. - Google Patents
Agente terapeutico y procedimiento que inhibe la vascularizacion de tumores.Info
- Publication number
- ES2087915T3 ES2087915T3 ES90914867T ES90914867T ES2087915T3 ES 2087915 T3 ES2087915 T3 ES 2087915T3 ES 90914867 T ES90914867 T ES 90914867T ES 90914867 T ES90914867 T ES 90914867T ES 2087915 T3 ES2087915 T3 ES 2087915T3
- Authority
- ES
- Spain
- Prior art keywords
- vascularization
- therapeutic agent
- tumors
- inhibits
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940124597 therapeutic agent Drugs 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000003053 toxin Substances 0.000 abstract 3
- 231100000765 toxin Toxicity 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE PRESENTA UN METODO Y UN AGENTE TERAPEUTICO PARA INHIBIR AL MENOS PARCIALMENTE LA VASCULARIZACION DE UN TUMOR SOLIDO EN DESARROLLO. EL AGENTE TERAPEUTICO COMPRENDE TOXINA POLYSACARIDA. UNA TOXINA GBS, PRODUCIDA POR UNA BACTERIA DEL GRUPO B BETA-HEMOLITICA STERPTOCOCCUS. EL AGENTE GBS, SE PRESENTA EN FORMA DE TOXINA ACTIVA PURIFICADA, PUDIENDO SER ADMINISTRADA VIA PARENTERAL EN DOSIS EFECTIVA PARA INHIBIR LA VASCULARIZACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/411,674 US5010062A (en) | 1989-09-25 | 1989-09-25 | Therapeutic agent and method of inhibiting vascularization of tumors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2087915T3 true ES2087915T3 (es) | 1996-08-01 |
Family
ID=23629867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90914867T Expired - Lifetime ES2087915T3 (es) | 1989-09-25 | 1990-09-13 | Agente terapeutico y procedimiento que inhibe la vascularizacion de tumores. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5010062A (es) |
EP (1) | EP0445280B1 (es) |
JP (1) | JPH0662426B2 (es) |
AT (1) | ATE136222T1 (es) |
AU (1) | AU626733B2 (es) |
CA (1) | CA2042032C (es) |
DE (1) | DE69026371T2 (es) |
DK (1) | DK0445280T3 (es) |
ES (1) | ES2087915T3 (es) |
WO (1) | WO1991004048A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5811403A (en) * | 1996-09-30 | 1998-09-22 | Vanderbilt University | Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity |
US5981508A (en) | 1997-01-29 | 1999-11-09 | Vanderbilt University | Facilitation of repair of neural injury with CM101/GBS toxin |
US6028060A (en) * | 1997-01-29 | 2000-02-22 | Vanderbilt University | Treatment of chronic inflammatory diseases with CM101/GBS toxin |
US5858991A (en) * | 1997-01-29 | 1999-01-12 | Vanderbilt University | Facilitation of wound healing with CM101/GBS toxin |
US6670337B1 (en) | 1998-01-29 | 2003-12-30 | Yeda Reaearch And Development Co., Ltd. | Facilitation of wound healing with CM101/GBS toxin |
US6756361B1 (en) * | 1997-10-14 | 2004-06-29 | Nabi | Enterococcus antigens and vaccines |
US6803448B1 (en) | 1998-07-22 | 2004-10-12 | Vanderbilt University | GBS toxin receptor |
US8609614B2 (en) * | 1998-07-22 | 2013-12-17 | Vanderbilt University | GBS toxin receptor compositions and methods of use |
US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
CN100400100C (zh) * | 2000-02-02 | 2008-07-09 | 范德比尔特大学 | Gbs毒素受体的制药用途 |
CA2512812A1 (en) * | 2003-01-09 | 2004-07-29 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS557014A (en) * | 1978-06-29 | 1980-01-18 | Chugai Pharmaceut Co Ltd | Antitumor agent and its preparation |
US4522803A (en) * | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
NZ222192A (en) * | 1986-10-20 | 1991-03-26 | Kanto Ishi Pharma Co Ltd | Glycolipid containing n-glycolylneuraminic acid, and preparation thereof |
US4939083A (en) * | 1986-10-30 | 1990-07-03 | La Jolla Cancer Research Foundation | Carbohydrate specific to chronic myelogenous leukemia granulocytes |
US4895838A (en) * | 1988-03-09 | 1990-01-23 | Trustees Of Boston University | Method for provoking angiogenesis by administration of angiogenically active oligosaccharides |
-
1989
- 1989-09-25 US US07/411,674 patent/US5010062A/en not_active Expired - Lifetime
-
1990
- 1990-09-13 JP JP2513756A patent/JPH0662426B2/ja not_active Expired - Fee Related
- 1990-09-13 DK DK90914867.8T patent/DK0445280T3/da active
- 1990-09-13 AU AU65135/90A patent/AU626733B2/en not_active Ceased
- 1990-09-13 CA CA002042032A patent/CA2042032C/en not_active Expired - Fee Related
- 1990-09-13 EP EP90914867A patent/EP0445280B1/en not_active Expired - Lifetime
- 1990-09-13 WO PCT/US1990/005177 patent/WO1991004048A1/en active IP Right Grant
- 1990-09-13 ES ES90914867T patent/ES2087915T3/es not_active Expired - Lifetime
- 1990-09-13 AT AT90914867T patent/ATE136222T1/de not_active IP Right Cessation
- 1990-09-13 DE DE69026371T patent/DE69026371T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69026371T2 (de) | 1996-08-01 |
ATE136222T1 (de) | 1996-04-15 |
AU6513590A (en) | 1991-04-18 |
AU626733B2 (en) | 1992-08-06 |
JPH04501870A (ja) | 1992-04-02 |
CA2042032A1 (en) | 1991-03-26 |
EP0445280B1 (en) | 1996-04-03 |
DK0445280T3 (da) | 1996-07-08 |
JPH0662426B2 (ja) | 1994-08-17 |
US5010062A (en) | 1991-04-23 |
CA2042032C (en) | 1995-10-10 |
WO1991004048A1 (en) | 1991-04-04 |
DE69026371D1 (de) | 1996-05-09 |
EP0445280A1 (en) | 1991-09-11 |
EP0445280A4 (en) | 1993-05-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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