ES2087812A1 - Decahydroisoquinoline derivatives useful as exciter amino acid receptor antagonists - Google Patents

Decahydroisoquinoline derivatives useful as exciter amino acid receptor antagonists

Info

Publication number
ES2087812A1
ES2087812A1 ES09301493A ES9301493A ES2087812A1 ES 2087812 A1 ES2087812 A1 ES 2087812A1 ES 09301493 A ES09301493 A ES 09301493A ES 9301493 A ES9301493 A ES 9301493A ES 2087812 A1 ES2087812 A1 ES 2087812A1
Authority
ES
Spain
Prior art keywords
exciter
amino acid
receptor antagonists
acid receptor
decahydroisoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301493A
Other languages
Spanish (es)
Other versions
ES2087812B1 (en
Inventor
Bret Eugene Huff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to ES9301493A priority Critical patent/ES2087812B1/en
Publication of ES2087812A1 publication Critical patent/ES2087812A1/en
Application granted granted Critical
Publication of ES2087812B1 publication Critical patent/ES2087812B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

Decahydroisoquinoline derivatives useful as exciter amino acid receptor antagonists. Derivatives of decahydroisoquinoline of formula (I) where R1 is H, alkyl, arylalkyl, alkoxycarbonyl or acyl, R2 is H, alkyl, which may be substituted, cycloalkyl or arylalkyl, R3 is CO2H, SO3H, CONHSO2R8 or a five-member ring containing one to four N atoms and, optionally, one atom of O or S, which may optionally be substituted, W is (CH2)n, S, SO, SO2, Y is CHR7, NR4, O, S, SO or SO2, Z is NR6, CHR7, CH or W and Y together are HC=CH or CC, or Y and Z together are HC=CH or CC, are useful as exciter amino acid antagonists, as a result of which they can be used in the treatment of neurological disorders and in the production of analgesia.
ES9301493A 1993-07-02 1993-07-02 DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS. Expired - Fee Related ES2087812B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301493A ES2087812B1 (en) 1993-07-02 1993-07-02 DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301493A ES2087812B1 (en) 1993-07-02 1993-07-02 DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS.

Publications (2)

Publication Number Publication Date
ES2087812A1 true ES2087812A1 (en) 1996-07-16
ES2087812B1 ES2087812B1 (en) 1997-03-16

Family

ID=8282429

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301493A Expired - Fee Related ES2087812B1 (en) 1993-07-02 1993-07-02 DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS.

Country Status (1)

Country Link
ES (1) ES2087812B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ORNSTEIN y col. 6-Substituted Decahydroisoquinolines-3-carboxylic Acids as Potent and Selective Conformationally Constrained NMDA Receptor Antagonists. J. Med. Chem. 1992, Vol. 35, pßginas 3547-3560 *

Also Published As

Publication number Publication date
ES2087812B1 (en) 1997-03-16

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Legal Events

Date Code Title Description
EC2A Search report published

Effective date: 19960716

FD1A Patent lapsed

Effective date: 20040503