ES2087812A1 - Decahydroisoquinoline derivatives useful as exciter amino acid receptor antagonists - Google Patents
Decahydroisoquinoline derivatives useful as exciter amino acid receptor antagonistsInfo
- Publication number
- ES2087812A1 ES2087812A1 ES09301493A ES9301493A ES2087812A1 ES 2087812 A1 ES2087812 A1 ES 2087812A1 ES 09301493 A ES09301493 A ES 09301493A ES 9301493 A ES9301493 A ES 9301493A ES 2087812 A1 ES2087812 A1 ES 2087812A1
- Authority
- ES
- Spain
- Prior art keywords
- exciter
- amino acid
- receptor antagonists
- acid receptor
- decahydroisoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Decahydroisoquinoline derivatives useful as exciter amino acid receptor antagonists. Derivatives of decahydroisoquinoline of formula (I) where R1 is H, alkyl, arylalkyl, alkoxycarbonyl or acyl, R2 is H, alkyl, which may be substituted, cycloalkyl or arylalkyl, R3 is CO2H, SO3H, CONHSO2R8 or a five-member ring containing one to four N atoms and, optionally, one atom of O or S, which may optionally be substituted, W is (CH2)n, S, SO, SO2, Y is CHR7, NR4, O, S, SO or SO2, Z is NR6, CHR7, CH or W and Y together are HC=CH or CC, or Y and Z together are HC=CH or CC, are useful as exciter amino acid antagonists, as a result of which they can be used in the treatment of neurological disorders and in the production of analgesia.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301493A ES2087812B1 (en) | 1993-07-02 | 1993-07-02 | DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301493A ES2087812B1 (en) | 1993-07-02 | 1993-07-02 | DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2087812A1 true ES2087812A1 (en) | 1996-07-16 |
ES2087812B1 ES2087812B1 (en) | 1997-03-16 |
Family
ID=8282429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9301493A Expired - Fee Related ES2087812B1 (en) | 1993-07-02 | 1993-07-02 | DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2087812B1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
-
1993
- 1993-07-02 ES ES9301493A patent/ES2087812B1/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
Non-Patent Citations (1)
Title |
---|
ORNSTEIN y col. 6-Substituted Decahydroisoquinolines-3-carboxylic Acids as Potent and Selective Conformationally Constrained NMDA Receptor Antagonists. J. Med. Chem. 1992, Vol. 35, pßginas 3547-3560 * |
Also Published As
Publication number | Publication date |
---|---|
ES2087812B1 (en) | 1997-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Effective date: 19960716 |
|
FD1A | Patent lapsed |
Effective date: 20040503 |