ES2086323T3 - DIDESOXY-ARABINITOL DERIVATIVES AS ANTIVIRIC COMPOUNDS. - Google Patents
DIDESOXY-ARABINITOL DERIVATIVES AS ANTIVIRIC COMPOUNDS.Info
- Publication number
- ES2086323T3 ES2086323T3 ES89870169T ES89870169T ES2086323T3 ES 2086323 T3 ES2086323 T3 ES 2086323T3 ES 89870169 T ES89870169 T ES 89870169T ES 89870169 T ES89870169 T ES 89870169T ES 2086323 T3 ES2086323 T3 ES 2086323T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- antiviric
- didesoxy
- arabinitol
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/164—Unsaturated ethers containing six-membered aromatic rings
- C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/40—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with ozone; by ozonolysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Novel antiviral compounds are disclosed having the following formula <CHEM> wherein R1 is C1-C14 alkyl or C1-C14 hydroxyalkyl or C3-C12 alkanoyl or a substituted or unsubstituted aryl radical having six to ten carbon atoms; and wherein R2, R3 and R4 are the same or different and each is H or acyl having one to six carbon atoms; provided, however, that when R2, R3 and R4 are each H, then R1 is C4-C9 alkyl or C2-C5 hydroxyalkyl or C3-C12 alkanoyl.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/266,718 US4876268A (en) | 1988-11-03 | 1988-11-03 | Antiviral compounds and use thereof |
US07/410,640 US4973602A (en) | 1988-11-03 | 1989-09-26 | Antiviral compounds and a method of use thereas |
US07/410,638 US4937357A (en) | 1988-11-03 | 1989-09-26 | Intermediates for antiviral compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2086323T3 true ES2086323T3 (en) | 1996-07-01 |
Family
ID=27401904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89870169T Expired - Lifetime ES2086323T3 (en) | 1988-11-03 | 1989-10-31 | DIDESOXY-ARABINITOL DERIVATIVES AS ANTIVIRIC COMPOUNDS. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0367747B1 (en) |
JP (1) | JP2840334B2 (en) |
AT (1) | ATE135346T1 (en) |
CA (1) | CA2002105C (en) |
DE (1) | DE68925940T2 (en) |
ES (1) | ES2086323T3 (en) |
GR (1) | GR3019885T3 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP9901132A2 (en) * | 1995-09-08 | 1999-07-28 | Novo Nordisk A/S | 2-alkylpyrrolidines |
EP1037636A4 (en) | 1997-12-11 | 2004-08-18 | Univ Oxford | Inhibition of membrane-associated viral replication |
AU1840101A (en) * | 1999-08-10 | 2001-03-05 | Chancellor, Masters And Scholars Of The University Of Oxford, The | Long chain n-alkyl compounds and oxo-derivatives thereof |
JP5241709B2 (en) * | 2006-05-24 | 2013-07-17 | ユナイテッド セラピューティクス コーポレーション | Deoxynojirimycin and D-arabinitol analogs and methods of use |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
-
1989
- 1989-10-31 ES ES89870169T patent/ES2086323T3/en not_active Expired - Lifetime
- 1989-10-31 AT AT89870169T patent/ATE135346T1/en not_active IP Right Cessation
- 1989-10-31 EP EP89870169A patent/EP0367747B1/en not_active Expired - Lifetime
- 1989-10-31 DE DE68925940T patent/DE68925940T2/en not_active Expired - Fee Related
- 1989-11-02 JP JP1287315A patent/JP2840334B2/en not_active Expired - Fee Related
- 1989-11-02 CA CA002002105A patent/CA2002105C/en not_active Expired - Fee Related
-
1996
- 1996-05-10 GR GR960401265T patent/GR3019885T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2840334B2 (en) | 1998-12-24 |
GR3019885T3 (en) | 1996-08-31 |
CA2002105A1 (en) | 1990-05-03 |
EP0367747A2 (en) | 1990-05-09 |
CA2002105C (en) | 1999-01-19 |
DE68925940D1 (en) | 1996-04-18 |
ATE135346T1 (en) | 1996-03-15 |
EP0367747A3 (en) | 1991-05-08 |
EP0367747B1 (en) | 1996-03-13 |
JPH02172972A (en) | 1990-07-04 |
DE68925940T2 (en) | 1996-10-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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