ES2081993T3 - Procedimiento de ensayo para diagnostico. - Google Patents

Procedimiento de ensayo para diagnostico.

Info

Publication number
ES2081993T3
ES2081993T3 ES90909892T ES90909892T ES2081993T3 ES 2081993 T3 ES2081993 T3 ES 2081993T3 ES 90909892 T ES90909892 T ES 90909892T ES 90909892 T ES90909892 T ES 90909892T ES 2081993 T3 ES2081993 T3 ES 2081993T3
Authority
ES
Spain
Prior art keywords
assay
sites
ligand
proteins
unoccupied
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909892T
Other languages
English (en)
Inventor
John J Blackwood
Shai Inbar
James V Patzke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Behring Diagnostics Inc
Original Assignee
Behring Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behring Diagnostics Inc filed Critical Behring Diagnostics Inc
Application granted granted Critical
Publication of ES2081993T3 publication Critical patent/ES2081993T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Selective Calling Equipment (AREA)
  • Measurement Of Radiation (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

SE DESCRIBE UN SISTEMA DE ENSAYO PARA EVALUAR LOS LUGARES DE ENLACE DE LIGANDOS ESPECIFICOS DESOCUPADOS DE PROTEINAS EN FLUIDOS BIOLOGICOS. EL ENSAYO SE LLEVA A CABO CON UN ELEMENTO DE ENSAYO DE MULTIPLES CAPAS Y SE BASA EN EL PRINCIPIO DE DISTRIBUCION POR EQUILIBRIO SEGUN EL CUAL UN LIGANDO SE DISTRIBUYE A SI MISMO ENTRE LOS LUGARES DESOCUPADOS DE LAS PROTEINAS Y EL RESTO DEL ELEMENTO. EL LIGANDO SE PUEDE ETIQUETAR CON UNA UNIDAD DETECTABLE O SE PUEDE NO ESTAR ETIQUETADO Y DETECTARLO UTILIZANDO OTRAS ESPECIES DETECTABLES. EN UN ASPECTO DE LA INVENCION, SE UTILIZA EL FORMATO DEL ENSAYO PARA ESTIMAR EL NUMERO DE LUGARES EN LA GLOBULINA AGLUTINANTE DE LA TIROXINA (TBG) NO OCUPADOS POR LA TIROXINA (T4) NI LA TRIYODOTIRONINA (T3).
ES90909892T 1989-07-11 1990-06-12 Procedimiento de ensayo para diagnostico. Expired - Lifetime ES2081993T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/378,062 US5364796A (en) 1989-07-11 1989-07-11 Diagnostic assay system

Publications (1)

Publication Number Publication Date
ES2081993T3 true ES2081993T3 (es) 1996-03-16

Family

ID=23491573

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909892T Expired - Lifetime ES2081993T3 (es) 1989-07-11 1990-06-12 Procedimiento de ensayo para diagnostico.

Country Status (9)

Country Link
US (1) US5364796A (es)
EP (1) EP0617790B1 (es)
JP (1) JP2574068B2 (es)
AT (1) ATE130103T1 (es)
CA (1) CA2018856A1 (es)
DE (1) DE69023517T2 (es)
DK (1) DK0617790T3 (es)
ES (1) ES2081993T3 (es)
WO (1) WO1991001006A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2960628B2 (ja) * 1992-06-26 1999-10-12 イーストマン コダック カンパニー 標識サイロニンハプテン類似体を用いたイムノアッセイ
US5741714A (en) * 1995-07-18 1998-04-21 Immunivest Corporation Detection of bound analyte by magnetic partitioning and masking
US5660990A (en) * 1995-08-18 1997-08-26 Immunivest Corporation Surface immobilization of magnetically collected materials
WO1999023475A1 (en) * 1997-10-31 1999-05-14 Dade Behring Inc. Chromogenic and turbidimetric assay device
US11703502B2 (en) * 2017-01-27 2023-07-18 Becton, Dickinson And Company Vertical flow assay device for detecting glucose concentration in a fluid sample

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941564A (en) * 1973-09-13 1976-03-02 Miles Laboratories, Inc. Method for assessing thyroid function
US4252782A (en) * 1978-09-29 1981-02-24 Meloy Laboratories, Inc. Test for assessing the unsaturated binding capacity of serum proteins which bind thyroid hormones
US4381291A (en) * 1979-02-23 1983-04-26 Ab Fortia Measurement of free ligands
US4333733A (en) * 1980-07-17 1982-06-08 Eastman Kodak Company Continuous release of reagent in an analytical element to reduce assay interference
AU555213B2 (en) * 1981-02-17 1986-09-18 Abbott Laboratories N-substituted-amido-fluoresein derivatives
EP0103605B1 (en) * 1982-03-19 1990-12-05 EKINS, Roger Philip Method for free ligand assays
JPS5977356A (ja) * 1982-06-30 1984-05-02 Fuji Photo Film Co Ltd 螢光アツセイ用多層分析要素およびそれを用いる螢光アツセイ法
US4476228A (en) * 1982-11-08 1984-10-09 Abbott Laboratories Determination of unsaturated thyroxine binding protein sites using fluorescence polarization techniques
GB2134806B (en) 1983-02-07 1986-07-16 English Clays Lovering Pochin A tube pressure filter
EP0131096A2 (en) * 1983-05-02 1985-01-16 Miles Laboratories, Inc. Homogeneous immunoassay method for determining binding substances and reagent system therefor
EP0165669A1 (en) * 1984-05-04 1985-12-27 Corning Glass Works Improved method of measuring free ligand
AU4108085A (en) * 1984-05-29 1985-12-05 Warner-Lambert Company Triiodothyronine uptake test
US4906439A (en) * 1986-03-25 1990-03-06 Pb Diagnostic Systems, Inc. Biological diagnostic device and method of use
US4900686A (en) * 1987-04-02 1990-02-13 Polaroid Corporation Fluorescent conjugates and biological diagnostic assay
US4824777A (en) * 1987-07-08 1989-04-25 Ciba Corning Diagnostics Corp. Method for determining thyroxine uptake
GB8800419D0 (en) * 1988-01-08 1988-02-10 Amersham Int Plc Method for measuring free fraction of ligands in biological fluids

Also Published As

Publication number Publication date
EP0617790A1 (en) 1994-10-05
DE69023517T2 (de) 1996-05-02
DK0617790T3 (da) 1996-02-26
WO1991001006A1 (en) 1991-01-24
ATE130103T1 (de) 1995-11-15
DE69023517D1 (de) 1995-12-14
EP0617790B1 (en) 1995-11-08
JP2574068B2 (ja) 1997-01-22
CA2018856A1 (en) 1991-01-11
JPH04500731A (ja) 1992-02-06
US5364796A (en) 1994-11-15

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