ES2069735T3 - Procedimiento para la produccion de 3-desoxi-4-en-esteroides. - Google Patents

Procedimiento para la produccion de 3-desoxi-4-en-esteroides.

Info

Publication number
ES2069735T3
ES2069735T3 ES90904244T ES90904244T ES2069735T3 ES 2069735 T3 ES2069735 T3 ES 2069735T3 ES 90904244 T ES90904244 T ES 90904244T ES 90904244 T ES90904244 T ES 90904244T ES 2069735 T3 ES2069735 T3 ES 2069735T3
Authority
ES
Spain
Prior art keywords
group
pct
hydrogen atom
ethylidene
date oct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90904244T
Other languages
English (en)
Inventor
Ekkehard Winterfeldt
Ulf Tilstamm
Helmut Hofmeister
Henry Laurent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2069735T3 publication Critical patent/ES2069735T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION TRATA DEL METODO DE PREPARACION DE ESTEROIDES 3-DESOXY-4 -ENE CON LA FORMULA GENERAL I, DONDE R SUB 1, R SUB 2 Y R SUB 3 SON ATOMOS DE HIDROGENO O UN GRUPO METYL, R SUB 4 ES UN GRUPO DE ALKYL BAJO, UN GRUPO FENIL O UN GRUPO HIDROXILO LIBRE, ESTERIFICADO O ETERIFICADO, R SUB 5 ES UN ATOMO DE HIDROGENO, UN GRUPO VINILO O LA AGRUPACION -C=CR SUB 6, R SUB 6 ES UN ATOMO DE HIDROGENO, UN GRUPO ALKYL CON UN MINIMO DE 4 ATOMOS DE CARBONO O UN ATOMO DE HALOGENO, X ES UN GRUPO DE METILENO, Y Y U SON GRUPOS DE METILENO O DE ETILIDENO, Y Z ES UN GRUPO DE METILENO, UN GRUPO DE ETILIDENO, UN GRUPO DE VINILIDENO, UN GRUPO DE CLOROMETILENO O UN GRUPO DE HIDROXIMETILENO, Y CUYOS ENLACES SON TRES ENLACES SIMPLES O UNO DOBLE Y DOS ENLACES SIMPLES O UN ENLACE DOBLE CONJUGADO. EL ESTEROIDE 3-OXO-4-ENE ES REDUCIDO UTILIZANDO UNA MEZCLA DE REACCION QUE LLEVA ACIDO TRIFUOROACETICO O TRICLOROACETICO, ACIDO CARBOXILICO ADICIONAL OPCIONAL Y BOROHIDRIDO DE SODIO.
ES90904244T 1989-03-21 1990-03-08 Procedimiento para la produccion de 3-desoxi-4-en-esteroides. Expired - Lifetime ES2069735T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3909770A DE3909770A1 (de) 1989-03-21 1989-03-21 Verfahren zur herstellung von 3-desoxy-4-en-steroiden

Publications (1)

Publication Number Publication Date
ES2069735T3 true ES2069735T3 (es) 1995-05-16

Family

ID=6377146

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90904244T Expired - Lifetime ES2069735T3 (es) 1989-03-21 1990-03-08 Procedimiento para la produccion de 3-desoxi-4-en-esteroides.

Country Status (9)

Country Link
US (1) US5140106A (es)
EP (1) EP0440752B1 (es)
JP (1) JPH03505740A (es)
AT (1) ATE119542T1 (es)
DD (1) DD292916A5 (es)
DE (2) DE3909770A1 (es)
DK (1) DK0440752T3 (es)
ES (1) ES2069735T3 (es)
WO (1) WO1990011290A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4330727C2 (de) * 1993-09-10 1998-02-19 Jenapharm Gmbh Steroidzwischenprodukte und Verfahren zu ihrer Herstellung
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
US7402577B2 (en) * 2001-10-03 2008-07-22 Merck & Co., Inc. Androstane 17-beta-carboxamides as androgen receptor modulators
ITMI20021755A1 (it) 2002-08-02 2002-11-01 Poli Ind Chimica Spa Processo e nuovi intermedi per la preparazione di steroidi ad attivita' progestinica.
ATE550041T1 (de) 2004-01-21 2012-04-15 Novo Nordisk Healthcare Ag Transglutaminase-vermittelte konjugation von peptiden
CN105237606B (zh) * 2014-07-11 2018-08-24 上海创诺制药有限公司 一种用于合成去氧孕烯的中间体及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3099656A (en) * 1962-02-26 1963-07-30 Syntex Corp delta3,5-pregnadiene derivatives
US3471531A (en) * 1966-04-07 1969-10-07 Herchel Smith Synthesis of gona-3,5-dienes
NL7017428A (es) * 1970-11-28 1972-05-30
DE3005374A1 (de) * 1980-02-11 1981-08-20 Schering Ag Berlin Und Bergkamen, 1000 Berlin 3-desoxy-delta hoch 15 -steroide, verfahren zu ihrer herstellung sowie diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
EP0440752B1 (de) 1995-03-08
DD292916A5 (de) 1991-08-14
DK0440752T3 (da) 1995-07-24
DE3909770A1 (de) 1990-09-27
JPH03505740A (ja) 1991-12-12
DE59008652D1 (de) 1995-04-13
WO1990011290A1 (de) 1990-10-04
ATE119542T1 (de) 1995-03-15
EP0440752A1 (de) 1991-08-14
US5140106A (en) 1992-08-18

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