ES2069476B1 - SYNTHESIS PROCEDURE OF PEPTIDES WITH THE CAPACITY TO DETECT ANTI-BODIES OF HEPATITIS C (HCV) IN SERUM OF AFFECTED INDIVIDUALS. - Google Patents

SYNTHESIS PROCEDURE OF PEPTIDES WITH THE CAPACITY TO DETECT ANTI-BODIES OF HEPATITIS C (HCV) IN SERUM OF AFFECTED INDIVIDUALS.

Info

Publication number
ES2069476B1
ES2069476B1 ES9301361A ES9301361A ES2069476B1 ES 2069476 B1 ES2069476 B1 ES 2069476B1 ES 9301361 A ES9301361 A ES 9301361A ES 9301361 A ES9301361 A ES 9301361A ES 2069476 B1 ES2069476 B1 ES 2069476B1
Authority
ES
Spain
Prior art keywords
arg
groups
chains
hepatitis
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9301361A
Other languages
Spanish (es)
Other versions
ES2069476A1 (en
Inventor
Lasarte Carmen Berasain
Jose Ignacio Riezu-Boj
Valtuna Jesus Prieto
Cuesta Francisco Borras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto Cientifico y Tecnologico de Navarra SA
Original Assignee
Instituto Cientifico y Tecnologico de Navarra SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES09101525A external-priority patent/ES2051152B1/en
Application filed by Instituto Cientifico y Tecnologico de Navarra SA filed Critical Instituto Cientifico y Tecnologico de Navarra SA
Publication of ES2069476A1 publication Critical patent/ES2069476A1/en
Application granted granted Critical
Publication of ES2069476B1 publication Critical patent/ES2069476B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

NUEVOS PEPTIDOS SINTETICOS PARA DETECTAN ANTICUERPOS CONTRA EL VIRUS DE LA HEPATITIS C. DICHOS PEPTIDOS SINTETICOS TIENEN EN SU ESTRUCTURA AL MENOS UNA DE LAS CADENAS PEPTIDICAS SIGUIENTES: (A)ALA PHE ALA SER ARG GLY ASN HIS VAL SER PRO THR HIS TYR VAL; (B) THR ASN ARG ARG PRO GLN ASP VAL LYS PHE PRO GLY GLY GLY VAL; (C) LYS PRO GLN ARG LYS THR LIS ARG ASN THR ASN ARG ARG PRO VAL; LAS CUALES PUEDEN: 1) ESTAR UNIDAS A: I) TRONCOS DE LISINAS EN LAS QUE LOS GRUPOS { -AMINO Y -AMINO ESTAN SUSTITUIDOS POR OTRAS LISINAS, EN LOS QUE LA UNION ENTRE DICHAS CADENAS PEPTIDICAS (A), (B) Y/O (C) Y LOS TRONCOS DE LISINA SE REALIZA POR LOS GRUPOS AMINO LIBRES DE LOS TRONCOS DE LISINA Y POR LOS GRUPOS CARBOXILOS TERMINALES DE DICHAS CADENAS PEPTIDICAS (A), (B) O (C); II) ALBUMINA SERICA BOBINA (BSA) U OTRA PROTEINA DE ALTO PESO MOLECULAR, EN LOS QUE LA UNION ENTRE LA PROTEINA Y LAS CADENAS PEPTIDICAS (A), (B) Y/O (C) PUEDE SER: A) POR EL GRUPO CARBOXILO TERMINAL DE LAS CADENAS PEPTIDICAS (A) (B) Y/O (C), YGRUPOS -AMINO DE LA PROTEINA, O B) POR CUALQUIERA DE LOS GRUPOS REACTIVOS LIBRES PRESENTES EN CUALQUIERA DE LOS PEPTIDOS; Y 2) ESTAR POLIMERIZADAS ENTRE SI. TAMBIEN SE DESCRIBE UN ENSAYO PARA LA DETECCION DE ANTICUERPOS CONTRA EL VIRUS DE LA HEPATITIS C, QUE EMPLEA DICHOS ANTICUERPOS. *FIG*NEW SYNTHETIC PEPTIDES TO DETECT ANTIBODIES AGAINST HEPATITIS V VIRUSES. SUCH SYNTHETIC PEPTIDES HAVE IN THEIR STRUCTURE AT LEAST ONE OF THE FOLLOWING PEPTIDICAL CHAINS: (A) ALA PHE ALA SER ARG GLY ASN HIS VAL SER (B) THR ASN ARG ARG PRO GLN ASP VAL LYS PHE PRO GLY GLY GLY VAL; (C) LYS PRO GLN ARG LYS THR LIS ARG ASN THR ASN ARG ARG PRO VAL; WHICH MAY: 1) BE ATTACHED TO: I) LYSINE STOCKS IN WHICH THE GROUPS {-AMINE AND -AMINE ARE REPLACED BY OTHER LYSINES, IN WHICH THE UNION BETWEEN SUCH PEPTIDIC CHAINS (A), (B) AND / OR (C) AND THE LYSINE STOCKS IS MADE BY THE FREE AMINO GROUPS OF THE LYSINE STEMS AND BY THE TERMINAL CARBOXYL GROUPS OF THESE PEPTIDIC CHAINS (A), (B) O (C); II) SERIC COIL ALBUMINA (BSA) OR OTHER HIGH MOLECULAR WEIGHT PROTEIN, IN WHICH THE UNION BETWEEN PROTEIN AND PEPTIDIC CHAINS MAY (A) BE: A) BY THE CARBOXYL GROUP TERMINAL OF PEPTIDIC CHAINS (A) (B) AND / OR (C), AND GROUPS -AMINE OF PROTEIN, OB) BY ANY OF THE FREE REACTIVE GROUPS PRESENT IN ANY OF THE PEPTIDES; AND 2) BE POLYMERIZED WITHIN EACH OTHER. ALSO DESCRIBES A TEST FOR THE DETECTION OF ANTIBODIES AGAINST THE HEPATITIS C VIRUS, WHICH USES SUCH ANTIBODIES. * FIG *

ES9301361A 1991-06-28 1993-06-18 SYNTHESIS PROCEDURE OF PEPTIDES WITH THE CAPACITY TO DETECT ANTI-BODIES OF HEPATITIS C (HCV) IN SERUM OF AFFECTED INDIVIDUALS. Expired - Lifetime ES2069476B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09101525A ES2051152B1 (en) 1991-03-20 1991-06-28 PROCEDURE OF SYSTESIS OF PEPTIDES WITH THE CAPACITY TO DETECT ANTI-BODIES ANTI-VIRUSES OF HEPATITIS C (HCV) IN SERUM OF AFFECTED INDIVIDUALS.

Publications (2)

Publication Number Publication Date
ES2069476A1 ES2069476A1 (en) 1995-05-01
ES2069476B1 true ES2069476B1 (en) 1996-01-01

Family

ID=8272838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301361A Expired - Lifetime ES2069476B1 (en) 1991-06-28 1993-06-18 SYNTHESIS PROCEDURE OF PEPTIDES WITH THE CAPACITY TO DETECT ANTI-BODIES OF HEPATITIS C (HCV) IN SERUM OF AFFECTED INDIVIDUALS.

Country Status (1)

Country Link
ES (1) ES2069476B1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106726A (en) * 1990-02-16 1992-04-21 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV
EP0485209A1 (en) * 1990-11-08 1992-05-13 Immuno Japan Inc. Non A, non B hepatitis virus related antigen, antibody detection systems, polynucleotides and polypeptides
EP0544861A4 (en) * 1991-06-13 1997-06-04 Baxter Diagnostics Inc Immunoassay for non-a non-b hepatitis
JPH05130874A (en) * 1991-11-07 1993-05-28 Sanwa Kagaku Kenkyusho Co Ltd Cdna of human hepatitis virus c, its clone and their utilization

Also Published As

Publication number Publication date
ES2069476A1 (en) 1995-05-01

Similar Documents

Publication Publication Date Title
Bulinski et al. Peptide antibody specific for the amino terminus of skeletal muscle alpha-actin.
Glenner et al. Amyloid fibril proteins: proof of homology with immunoglobulin light chains by sequence analyses
ES2599010T3 (en) T lymphocyte receptors with high HIV affinity
WO1997008203A1 (en) Structural mimics of rgd-binding sites
DE69232064D1 (en) Peptides as amylin agonists and their use
DK1218751T3 (en) Celiac disease using a gliadin epitope
Bennett et al. Isolation of an immunoreactive analogue of brain fodrin that is associated with the cell cortex of Dictyostelium amoebae
Dunigan et al. Tobacco mosaic virus particles contain ubiquitinated coat protein subunits
KR920701246A (en) Antagonist of GM-CSF derived from carboxyl terminus
CN102023219B (en) Composition for detecting rheumatoid arthritis immune antibody by colloidal gold lateral chromatography
KR910016769A (en) Peptides and Uses thereof
DE69333760D1 (en) EVALUATION OF PATIENTS WITH PROGRESSIVE IMMUNOSUPPRESSION
CA2111325A1 (en) Detection of mammalian immunodeficiency viruses
Cook et al. Binding of glycoprotein IIIa-derived peptide 217–231 to fibrinogen and von Willebrand factors and its inhibition by platelet glycoprotein IIb/IIIa complex
ES2069476B1 (en) SYNTHESIS PROCEDURE OF PEPTIDES WITH THE CAPACITY TO DETECT ANTI-BODIES OF HEPATITIS C (HCV) IN SERUM OF AFFECTED INDIVIDUALS.
EP1715046A3 (en) New polypeptide, DNA encoding the polypeptide, recombinant vector bearing the DNA and recombinant virus utilizing the recombinant vector as well as use thereof
Trotter et al. Biochemical characterization of fibrillar collagen from the mutable spine ligament of the sea-urchin Eucidaris tribuloides
CN101865913B (en) Composition for detecting rheumatoid arthritis immune antibody by lateral chromatography
CA2075366A1 (en) Immunologically active peptides or polypeptides from the parvovirus b19
Shi et al. The antigenicity of myoglobin-related peptides synthesised on polyacrylamide and polystyrene resin supports
Schimz et al. Enzymatic and immunological detection of a G-protein in Halobacterium halobium
NO903681L (en) MONOCLONAL ANTIBODIES AGAINST ACTIVATED RACE PROTEINS WITH AMINO ACID MUTIONS IN POSITION 13 IN THE PROTEIN.
Weisel et al. The coiled-coil structure: identity of the two chains of Mercenaria paramyosin
ATE162799T1 (en) PEPTIDES WITH THIOL PROTECTED CYSTEIN FOR USE IN IMMUNE TESTS
DE69018325D1 (en) P. falciparum sporozoite and hepatic phase antigen protein.