ES2065234B1 - COMPOUNDS TO TREAT DISEASES RELATED TO LEUCOTRENEES. - Google Patents

COMPOUNDS TO TREAT DISEASES RELATED TO LEUCOTRENEES.

Info

Publication number
ES2065234B1
ES2065234B1 ES9202153A ES9202153A ES2065234B1 ES 2065234 B1 ES2065234 B1 ES 2065234B1 ES 9202153 A ES9202153 A ES 9202153A ES 9202153 A ES9202153 A ES 9202153A ES 2065234 B1 ES2065234 B1 ES 2065234B1
Authority
ES
Spain
Prior art keywords
hydrogen
compounds
aliphatic
alkyl
diseases related
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9202153A
Other languages
Spanish (es)
Other versions
ES2065234A1 (en
Inventor
Pamela Anne Chambers
Robert A Daines
Dalia R Jakas
William D Kingsbury
Israil Pendrak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Priority to ES9202153A priority Critical patent/ES2065234B1/en
Publication of ES2065234A1 publication Critical patent/ES2065234A1/en
Application granted granted Critical
Publication of ES2065234B1 publication Critical patent/ES2065234B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

COMPUESTOS PARA TRATAR ENFERMEDADES RELACIONADAS CON LOS LEUCOTRIENOS, DE FORMULA *FORMULA* SUS N-OXIDOS Y SALES DONDE Z ES O, NH, NCH3 O S(O)0-Z; M ES 0-5; R ES UN GRUPO ALIFATICO O FENIL-ALIFATICO, EVENTUALMENTE ETERIFICADOS; R1 ES R4, CH2OH, CHO O UN GRUPO ALIFATICO SUSTITUIDO CON R4, CHO O CH2OR8;R2 ES HIDROGENO, HALO, ALQUILO, ALCOXI, CN (CH2)0-5R4, CH(NH2) (R4) O (CH2)0-5R9; R3 ES HIDROGENO, ALQUILO, ALCOXI, HALO, CN, R4,NHCONH2 U OH:R4 ES COR5, SULFONAMIDA, AMIDA O TETRAZOL-5-ILO: R5 ES N(R7)2,OH, UN GRUPO FORMADOR DE ESTER O UN CATION LIGADO A OXIGENO: R7 ES HIDROGENO O UN GRUPO ALIFATICO, ACILO O CICLOALQUIL-(CH2)0-3, P UDIENDO FORMAR AMBOS R7 UN ANILLO DE 4-6 CARBONOS: R8 ES HIDROGENO, ALQUILO O ACILO: Y R9 ES N(R7)2. ESTOS COMPUESTOS PUEDEN TRANSF ORMARSE EN COMPOSICIONES FARMACEUTICAS UTILES PARA TRATAR LA PSORIASIS.COMPOUNDS FOR TREATING DISEASES RELATED TO LEUKOTRIENES, OF FORMULA * FORMULA * ITS N-OXIDES AND SALTS WHERE Z IS O, NH, NCH3 OR S (O) 0-Z; M IS 0-5; R IS AN ALIPHATIC OR PHENYL-ALIPHATIC GROUP, EVENTUALLY ETERIFIED; R1 IS R4, CH2OH, CHO OR AN ALIPHATIC GROUP SUBSTITUTED FOR R4, CHO OR CH2OR8; R2 IS HYDROGEN, HALO, ALKYL, ALCOXI, CN (CH2) 0-5R4, CH (NH2) (R4) O (CH2) 0- 5R9; R3 IS HYDROGEN, ALKYL, ALCOXY, HALO, CN, R4, NHCONH2 OR OH: R4 IS COR5, SULFONAMIDE, AMIDA OR TETRAZOLE-5-ILO: R5 IS N (R7) 2, OH, A FORMER GROUP OF ESTER OR A CATION OXYGEN-LINKED: R7 IS HYDROGEN OR AN ALIPHATIC, ACIL, OR CYCLOALKYL GROUP- (CH2) 0-3, PUTTING TO MAKE BOTH R7 A 4-6 CARBON RING: R8 IS HYDROGEN, ALKYL OR ACIL: AND R9 IS N )two. THESE COMPOUNDS CAN BE TRANSFORMED INTO USEFUL PHARMACEUTICAL COMPOSITIONS TO TREAT PSORIASIS.

ES9202153A 1992-10-27 1992-10-27 COMPOUNDS TO TREAT DISEASES RELATED TO LEUCOTRENEES. Expired - Lifetime ES2065234B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202153A ES2065234B1 (en) 1992-10-27 1992-10-27 COMPOUNDS TO TREAT DISEASES RELATED TO LEUCOTRENEES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202153A ES2065234B1 (en) 1992-10-27 1992-10-27 COMPOUNDS TO TREAT DISEASES RELATED TO LEUCOTRENEES.

Publications (2)

Publication Number Publication Date
ES2065234A1 ES2065234A1 (en) 1995-02-01
ES2065234B1 true ES2065234B1 (en) 1995-09-01

Family

ID=8278577

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202153A Expired - Lifetime ES2065234B1 (en) 1992-10-27 1992-10-27 COMPOUNDS TO TREAT DISEASES RELATED TO LEUCOTRENEES.

Country Status (1)

Country Link
ES (1) ES2065234B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125788B1 (en) * 1995-12-12 1999-11-16 Exclusivas Sarabia S A COMPOSITION OF A FUNGICIDE PRODUCT FOR THE CONTROL OF POST-HARVEST FUNGIC DISEASES AND POST-HARVEST OF PEARS AND APPLES.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056619A (en) * 1975-09-08 1977-11-01 Warner-Lambert Company 1-Substituted-2-(2-pyridinyl)ethanone N-oxides
IT1204948B (en) * 1987-03-13 1989-03-10 Boheringer Biochemia Robin S P 2-THYOMETHY-SUBSTITUTE-PYRIDINS, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
JPH05507698A (en) * 1990-06-07 1993-11-04 スミスクライン・ビーチャム・コーポレイション Amide-linked pyridyl-benzoic acid derivatives for the treatment of leukotriene-related diseases
CA2083957A1 (en) * 1990-06-07 1991-12-08 Robert A. Daines Pyridyl-benzoic acid derivatives for treating leukotriene-related diseases
JPH06501019A (en) * 1990-09-13 1994-01-27 スミスクライン・ビーチャム・コーポレイション Pyridylthio or pyridyloxyalkanoic acid

Also Published As

Publication number Publication date
ES2065234A1 (en) 1995-02-01

Similar Documents

Publication Publication Date Title
IL64905A (en) Process for the preparation of 2-penems,carbapenems,carbacephams,oxapenems,and azapenems,some novel such compounds and pharmaceutical compositions containing them
ES8207156A1 (en) Pyrimidones, their preparation and medicines containing them.
SE8004002L (en) THERAPEUTICALLY APPLICABLE TETRALIN DERIVATIVES
SE8201854L (en) N-SUBSTITUTED AMINO AMINOS ACIDS
ES2165857T3 (en) GABA AND L-GLUTAMIC ACID ANALOGS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEMS.
MX9300031A (en) DERIVATIVES OF PIPERAZINE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM.
ES2032749T3 (en) OXOFTALAZINYL-HETERO-CYCLIC ACIDS.
ES520987A0 (en) PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF SPIRIT ACID (4. (3 + N)) - 2-AZA-3CARBOXILICO.
PT99135A (en) PROCESS FOR THE PREPARATION OF PIPERAZINE DERIVATIVES
FI880494A0 (en) NYA 5-ALCOXY-2,4-DIAMINOALKYLBENZENER SAMT DESSA INNEHAOLLANDE HAORFAERGNINGSMEDEL.
ES388869A1 (en) Cephalosporin intermediates and process therefor
ES2187025T3 (en) NEW IRON BURNING AGENTS (III) VIA ORAL ASSETS.
FR2403396A1 (en) WATER-MISCIBLE ANTI-CORROSIVE AGENTS CONTAINING AMINO-ALKANOIC ACIDS SULPHONYL WITH NITROGEN
MY101126A (en) Novel compounds
ES2065234B1 (en) COMPOUNDS TO TREAT DISEASES RELATED TO LEUCOTRENEES.
ES481551A1 (en) Bis(aryloxy-alcanecarboxylic compounds, their preparation and their therapeutic use.
ES2131549T3 (en) 16-LINK MACROLID DERIVATIVES AND THEIR PREPARATION PROCEDURE.
FI854596A (en) NYTT FOERFARANDE FOER UPPDELNING AV RACEMISKA -NAFTYLPROPIONSYROR I OPTISKA ISOMERER.
AR247879A1 (en) Pyrrolidine derivatives
FR2496638B1 (en)
ES550843A0 (en) PROCEDURE FOR OBTAINING COSMETIC SUPPRESSORS OF SEBUM BASED ON ALCOXI- OR ALKYL-BENCILOXI- BENZOIC ACIDS OR THEIR SALTS
ATE162191T1 (en) AZANORADAMANTANE
DE3569376D1 (en) 1,2,4-thiadiazines and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them
HU9403458D0 (en) 3-(phenylalkyl-aminoalkyloxy)-5-phenylpyrazol derivatives, process and intermediates for producing them, and pharmaceutical compositions containing them
GR3006582T3 (en)