ES2064228A1 - Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion. - Google Patents

Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.

Info

Publication number
ES2064228A1
ES2064228A1 ES09202203A ES9202203A ES2064228A1 ES 2064228 A1 ES2064228 A1 ES 2064228A1 ES 09202203 A ES09202203 A ES 09202203A ES 9202203 A ES9202203 A ES 9202203A ES 2064228 A1 ES2064228 A1 ES 2064228A1
Authority
ES
Spain
Prior art keywords
alkyl
hydroxy
hydrogen
alkoxy
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09202203A
Other languages
English (en)
Other versions
ES2064228B1 (es
Inventor
Carmen Almansa
Concepcion Gonzalez
M Carmen Torres
Elena Carceller
Javier Bartroli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES09202203A priority Critical patent/ES2064228B1/es
Priority to US08/049,865 priority patent/US5356915A/en
Priority to MX9302429A priority patent/MX9302429A/es
Priority to EP93107289A priority patent/EP0600147A1/en
Priority to JP5144239A priority patent/JPH07291932A/ja
Priority to CA002097045A priority patent/CA2097045A1/en
Priority to KR1019930020516A priority patent/KR940009154A/ko
Publication of ES2064228A1 publication Critical patent/ES2064228A1/es
Application granted granted Critical
Publication of ES2064228B1 publication Critical patent/ES2064228B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

NUEVAS TETRALONAS DE FORMULA GENERAL I, UTILES COMO REGULADORES DE LA CONTRACCION DE LA MUSCULATURA LISA EN LOS SISTEMAS CARDIOVASCULAR, BRONCOPULMONAR Y DIGESTIVO, EN DONDE RBS1 SC Y RBS2 SC SIGNIFICAN HIDROGENO, CIANO, NITRO, HALOGENO, HIDROXI O CSI1-4 SC ALCOXI; RBS3 SC Y RBS4 SC REPRESENTAN CSI1-4 SC ALQUILO, O BIEN RBS3 SC Y RBS4 SC JUNTOS FORMAN UNA CADENA DE CSI2-5 SC POLIMETILENO; RBS5 SC ES HIDROGENO EN CUYO CASO RBS6 SC ES HIDROGENO, HIDROXILO O CSI1-4 SC ALCOXI, O BIEN RBS5 SC ES HIDROXILO Y ENTONCES RBS6 SC ES HIDROGENO, O BIEN RBS5 SC-RBS6 SC JUNTO CON LOS CARBONOS DEL ANILLO FORMAN UN DOBLE ENLACE O UNA AGRUPACION DE TIPO EPOXIDO; RBS7 SC ES UN GRUPO 2-, 3- O 4-PIRIDILO QUE PUEDE ESTAR OPCIONALMENTE SUSTITUIDO POR UN GRUPO HIDROXILO O BIEN CUYO ATOMO DE NITROGENO PUEDE ESTAR OPCIONALMENTE EN FORMA DE N-OXIDO; Y SUS SALES LA PRESENTE INVENCION TAMBIEN DESCRIBE PROCEDIMIENTOS PARA SU OBTENCION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES09202203A 1992-10-19 1992-10-19 Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion. Expired - Fee Related ES2064228B1 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES09202203A ES2064228B1 (es) 1992-10-19 1992-10-19 Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.
US08/049,865 US5356915A (en) 1992-10-19 1993-04-20 Tetralones with pharmacological activity, compositions containing them
MX9302429A MX9302429A (es) 1992-10-19 1993-04-26 Nuevas tetralonas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
EP93107289A EP0600147A1 (en) 1992-10-19 1993-05-05 Tetralones with pharmacological activity, compositions containing them and process for their preparation
JP5144239A JPH07291932A (ja) 1992-10-19 1993-05-24 薬理活性を有する新規テトラロン類、それらを含有した組成物及びそれらの製造方法
CA002097045A CA2097045A1 (en) 1992-10-19 1993-05-26 Tetralones with pharmacological activity, compositions containing them and process for their preparation
KR1019930020516A KR940009154A (ko) 1992-10-19 1993-10-05 약리학적 활성을 갖는 테트랄론, 이를 함유하는 조성물 및 이의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09202203A ES2064228B1 (es) 1992-10-19 1992-10-19 Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.

Publications (2)

Publication Number Publication Date
ES2064228A1 true ES2064228A1 (es) 1995-01-16
ES2064228B1 ES2064228B1 (es) 1995-09-01

Family

ID=8278646

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09202203A Expired - Fee Related ES2064228B1 (es) 1992-10-19 1992-10-19 Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.

Country Status (7)

Country Link
US (1) US5356915A (es)
EP (1) EP0600147A1 (es)
JP (1) JPH07291932A (es)
KR (1) KR940009154A (es)
CA (1) CA2097045A1 (es)
ES (1) ES2064228B1 (es)
MX (1) MX9302429A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
JP4976134B2 (ja) * 2003-10-01 2012-07-18 アドラー コーポレーション スピロ環複素環誘導体及びそれらを使用する方法
US20060029530A1 (en) * 2004-08-09 2006-02-09 Gloria Gremillion Perfect tooth brush sterilize
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CN101534819A (zh) * 2006-09-12 2009-09-16 阿得罗公司 含氮的螺环化合物用于增强认知功能的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2318625A1 (fr) * 1975-07-24 1977-02-18 Beecham Group Ltd Composes polycycliques
EP0168619A1 (en) * 1984-06-12 1986-01-22 Beecham Group Plc N-acylated di- or tetrahydronaphthalenamines, and antihypertensive compositions containing them
EP0489300A2 (en) * 1990-12-05 1992-06-10 J. URIACH & CIA. S.A. Tetralones with pharmacological activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
CA2074864A1 (en) * 1991-07-30 1993-01-31 Carmen Almansa Tetralones with pharmacological activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2318625A1 (fr) * 1975-07-24 1977-02-18 Beecham Group Ltd Composes polycycliques
EP0168619A1 (en) * 1984-06-12 1986-01-22 Beecham Group Plc N-acylated di- or tetrahydronaphthalenamines, and antihypertensive compositions containing them
EP0489300A2 (en) * 1990-12-05 1992-06-10 J. URIACH & CIA. S.A. Tetralones with pharmacological activity

Also Published As

Publication number Publication date
ES2064228B1 (es) 1995-09-01
JPH07291932A (ja) 1995-11-07
KR940009154A (ko) 1994-05-20
CA2097045A1 (en) 1994-04-20
US5356915A (en) 1994-10-18
EP0600147A1 (en) 1994-06-08
MX9302429A (es) 1994-04-29

Similar Documents

Publication Publication Date Title
DE69417012T2 (de) Cyclobutan-derivate als inhibitoren der squalen-synthetase und der protein-farnesyltransferase
NZ324007A (en) Quinazoline derivatives susbtituted by a phenyl and medicaments
NZ330118A (en) Thiophenopyrimidines, pharmaceutical compositions thereof and use in treating endocrine, psychiatric and neurologic conditions
MY125533A (en) Heterocyclic dihydropyrimidine compounds
MY116761A (en) Novel spiroazabicyclic heterocyclic compounds.
MY123354A (en) 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
ES8101586A1 (es) Un procedimiento para la preparacion de nuevos derivados de quinazolina.
CA2295087A1 (en) Gastrokinetic monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
IL123655A (en) Substituted tetracyclic tetrahydrofuran derivatives and pharmaceutical compositions containing them
MY121275A (en) 2-substituted amino and thio alkyl benzoxazine antimicrobial agents
GEP20043214B (en) Complex of Ras-Farnesyltransferase Inhibitor and Sulfobutylether-7- Beta – Cyclodextrin or 2-Hydroxypropyl- Beta – Cyclodextrina and Pharmaceutical Compositions Containing the Same
YU89202A (sh) Faktor viia inhibitorni derivati (tio)uree, njihovo dobijanje i upotreba
HUT65574A (en) Process for preparing 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutical compositions containing them
IL165181A0 (en) The use of substituted cyanopyrrolidines and combination preparations containing them for treating hyperlipidemia and associated diseases
NZ212500A (en) Substituted chroman and chromene derivatives, their preparation and pharmaceutical compositions
ES2064228A1 (es) Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.
HU895226D0 (en) Process for the preparation of novel imidazoline derivatives and pharmaceutical compositions containing said compounds as active ingredients
AP9300561A0 (en) Antibiotic compounds.
NZ334033A (en) bicyclic aryl ring linked by propynylene or allenylene to phenyl, pyridine, thiochromane or chromane
MD502G2 (ro) Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
BR9909326A (pt) Derivados de piridina inibidores de pde iv
ES8600244A1 (es) Procedimiento de preparacion de nuevos derivados piridinicos y de sus sales de adicion acidas y cuaternarias
MY120046A (en) Angiogenesis inhibiting thiadiazolyl pyridazine derivatives.
ZA9811645B (en) Acronycine compounds a process for their preparation and pharmaceutical compositions containing them
IL149830A0 (en) Dimethylamino (ethylidene) thioamide derivatives, process for their preparation and use thereof in the preparation of angiogenesis inhibitors

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971020