ES2062340T3 - Derivados de 2-carbapenemo antibacterianos. - Google Patents

Derivados de 2-carbapenemo antibacterianos.

Info

Publication number
ES2062340T3
ES2062340T3 ES90303014T ES90303014T ES2062340T3 ES 2062340 T3 ES2062340 T3 ES 2062340T3 ES 90303014 T ES90303014 T ES 90303014T ES 90303014 T ES90303014 T ES 90303014T ES 2062340 T3 ES2062340 T3 ES 2062340T3
Authority
ES
Spain
Prior art keywords
pref
carbapenemo
antibacterials
derivatives
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90303014T
Other languages
English (en)
Inventor
John Jasys Vytautas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2062340T3 publication Critical patent/ES2062340T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

EL INVENTO SE REFIERE A LOS COMPUESTOS ANTIBACTERIANOS DE FORMULA (I) DONDE N ES 0 O 1, R ES HIDROGENO O UN RADICAL QUE FORMA UN ESTER HIDROLIZABLE BAJO CIERTAS CONDICIONES FISIOLOGICAS, Y R1 ES UN HIDROGENO O UN METIL), A LAS SALES CATIONICAS ACEPTABLES FARMACOLOGICAMENTE (EN LA QUE R1 REPRESENTA UN HIDROGENO), A LAS COMPOSICIONES FARMACOLOGICAS CORRESPONDIENTES Y A LOS INTERMEDIARIOS UTILES PARA LA SINTESIS DE TODOS ESTOS COMPUESTOS.
ES90303014T 1989-03-28 1990-03-21 Derivados de 2-carbapenemo antibacterianos. Expired - Lifetime ES2062340T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/001281 WO1990011284A1 (en) 1989-03-28 1989-03-28 Antibacterial 2-carbapenem derivatives

Publications (1)

Publication Number Publication Date
ES2062340T3 true ES2062340T3 (es) 1994-12-16

Family

ID=22214911

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90303014T Expired - Lifetime ES2062340T3 (es) 1989-03-28 1990-03-21 Derivados de 2-carbapenemo antibacterianos.

Country Status (24)

Country Link
EP (1) EP0392681B1 (es)
JP (1) JPH02286681A (es)
KR (1) KR920002132B1 (es)
CN (1) CN1024554C (es)
AT (1) ATE100104T1 (es)
AU (1) AU616345B2 (es)
CA (1) CA2013024A1 (es)
DD (1) DD293117A5 (es)
DE (1) DE69005875T2 (es)
DK (1) DK0392681T3 (es)
EG (1) EG19079A (es)
ES (1) ES2062340T3 (es)
FI (1) FI914558A0 (es)
HU (2) HUT63167A (es)
IE (1) IE901105L (es)
IL (1) IL93835A0 (es)
MX (1) MX20084A (es)
NO (1) NO913815L (es)
NZ (1) NZ233093A (es)
PH (1) PH26902A (es)
PT (1) PT93565A (es)
WO (1) WO1990011284A1 (es)
YU (1) YU59890A (es)
ZA (1) ZA902347B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
US5602118A (en) * 1993-03-16 1997-02-11 American Cyanamid Company 2-thiosubstituted carbapenems

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619924A (en) * 1984-05-18 1986-10-28 Pfizer Inc. 2-alkylthiopenem derivatives
US4757066A (en) * 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
EP0223397B1 (en) * 1985-10-17 1991-09-04 Pfizer Inc. Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics
EP0260042B1 (en) * 1986-09-04 1991-12-27 Pfizer Inc. 2-(1-oxo-1-imino-1-thiacycloalkyl)-thiopenem derivatives
WO1988008845A1 (en) * 1987-05-11 1988-11-17 Pfizer Inc. Diastereomeric 5r,6s-6-(1r-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids

Also Published As

Publication number Publication date
ZA902347B (en) 1991-11-27
CA2013024A1 (en) 1990-09-28
KR900014384A (ko) 1990-10-23
HU209817B (en) 1994-11-28
EP0392681B1 (en) 1994-01-12
DE69005875T2 (de) 1994-04-28
PH26902A (en) 1992-12-03
CN1024554C (zh) 1994-05-18
ATE100104T1 (de) 1994-01-15
YU59890A (en) 1991-10-31
DD293117A5 (de) 1991-08-22
WO1990011284A1 (en) 1990-10-04
EP0392681A1 (en) 1990-10-17
NO913815L (no) 1991-11-27
AU5229390A (en) 1990-10-04
PT93565A (pt) 1990-11-07
IL93835A0 (en) 1990-12-23
HUT64070A (en) 1993-11-29
DE69005875D1 (de) 1994-02-24
FI914558A0 (fi) 1991-09-27
HU895565D0 (en) 1992-07-28
DK0392681T3 (da) 1994-03-21
AU616345B2 (en) 1991-10-24
JPH02286681A (ja) 1990-11-26
NZ233093A (en) 1992-01-29
IE901105L (en) 1990-09-28
EG19079A (en) 1994-04-30
HUT63167A (en) 1993-07-28
MX20084A (es) 1993-03-01
CN1046164A (zh) 1990-10-17
NO913815D0 (no) 1991-09-27
KR920002132B1 (ko) 1992-03-12

Similar Documents

Publication Publication Date Title
AU5027393A (en) Benzo-fused lactams
NO180407C (no) Anvendelse av 1,3-oksatiolannukleosidanaloger ved fremstilling av et medikament for behandling av hepatitt B
FI881985A (fi) Foerfarande foer framstaellning av terapeutiskt verkande (s,s,s)-isomerer av substituerade acylderivat av 1,2,3,4-tetrahydroisokinolin-3-karboxylsyror.
AU679021B2 (en) N-heteroaryl-N'-phenylurea derivatives, their production and use
GR3032220T3 (en) Use of 2-(N-(2-aminoethyl)amino)acetic acid derivatives for the treatment of diseases which are mediated by non-enzymatical glycosylation
AU1302388A (en) Method of treating anxiety with tetrahydrobenz(c,d)indole-6- carboxamides
AU627631B2 (en) Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
ES2062340T3 (es) Derivados de 2-carbapenemo antibacterianos.
NO892002L (no) Fremgangsmaate ved fremstilling av enantiomere glutaramidderivater.
DE3765142D1 (de) Halogenide des esters aus 2-n,n,n-dimethyl-alkyl-amino-aethanol mit substituierter essigsaeure, sowie diese enthaltende arzneimittel mit entzuendungshemmender und antiseptischer wirkung.
AU7022796A (en) 2,3-dihydroxypropyl 2-(1-oxoalkyl)amino-2- deoxyglucopyranosides, a process for their preparation and their uses
EP0001715A3 (en) Azetidinone antibiotics and their pharmaceutical formulations and use
NO172493C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-beta (substituert)-(s)-hydroksymetylpenicillansyrer og derivater derav
MX9706187A (es) Derivados de 3-pirrolidiliden-2-ona-cefalosporinas.
FI931580A (fi) Menetelmä terapeuttisesti aktiivisten tetratsolijohdannaisten valmistamiseksi

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 392681

Country of ref document: ES