ES2059492T3 - Procedimiento para la preparacion de ibuprofen. - Google Patents

Procedimiento para la preparacion de ibuprofen.

Info

Publication number
ES2059492T3
ES2059492T3 ES88201365T ES88201365T ES2059492T3 ES 2059492 T3 ES2059492 T3 ES 2059492T3 ES 88201365 T ES88201365 T ES 88201365T ES 88201365 T ES88201365 T ES 88201365T ES 2059492 T3 ES2059492 T3 ES 2059492T3
Authority
ES
Spain
Prior art keywords
ibuprofen
preparation
procedure
ester
stereoselectively
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88201365T
Other languages
English (en)
Inventor
Mauro Attilio Bertola
Smet Marie Jose De
Arthur Friedrich Marx
Gareth Thomas Phillips
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Shell Internationale Research Maatschappij BV
Original Assignee
Gist Brocades NV
Shell Internationale Research Maatschappij BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV, Shell Internationale Research Maatschappij BV filed Critical Gist Brocades NV
Application granted granted Critical
Publication of ES2059492T3 publication Critical patent/ES2059492T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/823—Acetobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/882—Staphylococcus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA LA PREPARACION DE IBUPROFEN ENRIQUECIDO EN ISOMERO R, QUE COMPRENDE SOMETER UN ESTER DE IBUPROFEN A LA ACCION DE UN MICROORGANISMO O SUSTANCIAS DERIVADAS DE EL, LO QUE HIDROLIZA EL ESTER ESTEREOSELECTIVAMENTE PARA FORMAR IBUPROFEN QUE TIENE PREDOMINANTEMENTE CONFIGURACION R.
ES88201365T 1987-07-01 1988-06-30 Procedimiento para la preparacion de ibuprofen. Expired - Lifetime ES2059492T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878715476A GB8715476D0 (en) 1987-07-01 1987-07-01 Preparation of ibuprofen

Publications (1)

Publication Number Publication Date
ES2059492T3 true ES2059492T3 (es) 1994-11-16

Family

ID=10619903

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88201365T Expired - Lifetime ES2059492T3 (es) 1987-07-01 1988-06-30 Procedimiento para la preparacion de ibuprofen.

Country Status (8)

Country Link
US (1) US5108917A (es)
EP (1) EP0299558B1 (es)
JP (1) JP2793812B2 (es)
AT (1) ATE91721T1 (es)
DE (1) DE3882453T2 (es)
ES (1) ES2059492T3 (es)
GB (1) GB8715476D0 (es)
IE (1) IE61906B1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100204837B1 (ko) * 1989-04-28 1999-06-15 기스트 브로카데스 나암로제 베노오트하프 카르복실 에스테라제의 안정화
DE3919029A1 (de) * 1989-06-10 1990-12-13 Hoechst Ag Verfahren zur enzymatischen spaltung von 2-arylpropionsaeure-vinylester
EP0497103B1 (en) * 1991-01-10 1998-04-08 Sumitomo Chemical Company Limited Gene encoding asymmetrically active esterase
IT1247533B (it) * 1991-04-26 1994-12-17 Mini Ricerca Scient Tecnolog Processo per la separazione degli isomeri ottici di acidi carbossilici alfa-sostitutivi
US5273895A (en) * 1992-10-26 1993-12-28 Sepracor, Inc. Enantioselective production of chiral carboxylic acids
US5457051A (en) * 1993-03-09 1995-10-10 Sepracor, Inc. Enantioselective hydrolysis of ketoprofen esters by beauveria bassiana and enzymes derived therefrom
US5580783A (en) * 1994-10-12 1996-12-03 E. I. Du Pont De Nemours And Company Enzymatic process for the preparation of chiral α-tertiary carboxylic acid esters
US5843765A (en) * 1997-01-31 1998-12-01 National Research Council Of Canada Streptomyces microorganism useful for the preparation of (R)-baclofen from the racemic mixture
DE19716713A1 (de) * 1997-04-21 1998-10-22 Paz Arzneimittelentwicklung Arzneimittel, enthaltend Ibuprofenthioester als Hemmer der Nf-kappaB abhängigen Bildung von Mediatoren von Entzündung und Schmerz
US7358254B2 (en) * 2001-07-13 2008-04-15 Bristol-Myers Squibb Company Method for treating atherosclerosis employing an aP2 inhibitor and combination
US6844574B1 (en) 1999-03-12 2005-01-18 Sumitomo Chemical Company, Limited III-V compound semiconductor
JP4192331B2 (ja) * 1999-04-16 2008-12-10 住友化学株式会社 光学活性２−オキソビシクロ［３．１．０］ヘキサン−６−カルボン酸誘導体の製造方法
US6365399B1 (en) 1999-08-09 2002-04-02 Sumitomo Chemical Company, Limited Process for producing carboxylic acid isomer using Nocardia diaphanozonaria or Saccharopolyspora hirsuta
EP1551384A4 (en) * 2002-10-07 2008-04-09 Encore Pharmaceuticals Inc R-NSAID ESTERS AND ITS USE
WO2005015152A2 (en) * 2002-11-21 2005-02-17 Cole Philip L Remote sensing device to detect materials of varying atomic numbers
DE10352511A1 (de) * 2003-11-07 2005-06-16 Ernst-Moritz-Arndt-Universität Greifswald Verwendung von MRP4-Inhibitoren zur Behandlung und/oder Prophylaxe kardiovaskulärer Erkrankungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1201408B (it) * 1985-03-22 1989-02-02 Montedison Spa Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi
US4668628A (en) * 1985-04-01 1987-05-26 Stauffer Chemical Company Resolution of racemic mixtures of aliphatic acid esters
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids

Also Published As

Publication number Publication date
IE61906B1 (en) 1994-11-30
JPS6486898A (en) 1989-03-31
ATE91721T1 (de) 1993-08-15
DE3882453T2 (de) 1993-11-18
JP2793812B2 (ja) 1998-09-03
EP0299558A1 (en) 1989-01-18
EP0299558B1 (en) 1993-07-21
DE3882453D1 (de) 1993-08-26
GB8715476D0 (en) 1987-08-05
US5108917A (en) 1992-04-28
IE881981L (en) 1989-01-01

Similar Documents

Publication Publication Date Title
ES2059492T3 (es) Procedimiento para la preparacion de ibuprofen.
DE3675796D1 (de) Verfahren zur herstellung von entschleimten pflanzlichen oelen und schleim mit hohem gehalt an phosphatidischer saeure.
ES2021699B3 (es) Proceso para la preparacion de esteres.
DE3687946D1 (de) Verfahren zur herstellung der 2-keto-l-gulonsaeure.
DE3882242D1 (de) Fermentationsverfahren zur herstellung von 2-keto-l-gulonsaeuren.
ATE87664T1 (de) Verfahren zur herstellung von optisch aktiven 2- arylpropionsaeuren.
DE3885151D1 (de) Methode zur Herstellung von Methacrylatestern.
DE69220746D1 (de) Verfahren zur Herstellung einer mehrfach ungesättigten Fettsäure des Omega 9 Typs
DE68909627D1 (de) Verfahren zur Herstellung von Aktivkohle.
DE69016946D1 (de) Verfahren zur Herstellung von 4-O-Dopaminphosphaten und Dopaminderivate.
ES2159296T3 (es) Procedimiento para preparar 2,2-difluorocetena silil acetales y esteres de acido alfa,alfa-difluoro-beta-sililoxi-1,3-dioxolano-4-propanoico.
ATE95836T1 (de) Zum abbau von glycosaminoglycan faehige enzymzusammensetzung und verfahren zur herstellung dieser zusammensetzung.
ES2025122B3 (es) Procedimiento para obtencion de esteres de acidos alquencarboxilicos.
DE58905655D1 (de) Verfahren zur Isolierung bzw. Reinigung von im wesentlichen methylverzweigten, gesättigten C12-C24-Fettsäuren.
DE3874260D1 (de) Verfahren zur herstellung von estern ungesaettigter alkohole.
DE59007810D1 (de) Verfahren zur enzymatischen Spaltung von 2-Arylpropionsäurevinylestern.
DE3884272D1 (de) Verfahren zur Herstellung von Triglyceriden.
DE69016065D1 (de) Verfahren zur Herstellung von Calciumsalzen von Fettsäuren.
DE68912236D1 (de) Verfahren zur Herstellung von hochgradig ungesättigten Fettsäuren.
PT82352B (pt) Processo para a preparacao de uma composicao praguicida, nomeadamente insecticida e acaricida contendo esteres de acidos vinilciclopropanocarboxilicos
DE58907892D1 (de) Verfahren zur Herstellung von optisch aktiven alpha-Aminoacetalen.
ES551926A0 (es) Procedimiento de preparacion de metoprolol y-o de eter 4-(2-metoxietil)-fenilglicidilico
DE68911168D1 (de) Verfahren zur Herstellung von ungesättigten Carbonsäuren.
DE69021001D1 (de) Enzymatisches Verfahren zur Herstellung von L-Serin.
MX9304608A (es) Nuevas (n-metanosulfonil)-quinolilmetoxifenil-cicoalquilacetamidas sustituidas por isobutilo, procedimiento para su preparacion y medicamentos que las contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 299558

Country of ref document: ES