ES2058535T3 - Derivados de rizoxina y su utilizacion como agentes anti-tumorales. - Google Patents
Derivados de rizoxina y su utilizacion como agentes anti-tumorales.Info
- Publication number
- ES2058535T3 ES2058535T3 ES89306893T ES89306893T ES2058535T3 ES 2058535 T3 ES2058535 T3 ES 2058535T3 ES 89306893 T ES89306893 T ES 89306893T ES 89306893 T ES89306893 T ES 89306893T ES 2058535 T3 ES2058535 T3 ES 2058535T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- group
- rhizoxin
- alkyl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
DERIVADOS DE RIZOXINA Y RIZOXIN-2-ENO, DE FORMULA (I), EN LA QUE N ES 1-25; A ES UN ENLACE EXTRA U O; X ES O, S, N O CARBONILO; Y R ES HIDROGENO, ACILCARBOXILO QUE TIENE DE 1-25 ATOMOS DE CARBONO, ALCOXICARBONILO QUE TIENE DE 2-26 ATOMOS DE CARBONO, FOSFONO, ALQUILFOSFONO, EN EL QUE LA PARTE ALQUILO TIENE DE 1-25 ATOMOS DE CARBONO, DIALQUILFOSFONO, EN EL QUE CADA ALQUILO TIENE DE 1-25 ATOMOS DE CARBONO ARALQUILO, CICLOALQUILO, GRUPO HETEROCICLICO, ALQUILTIO EN EL QUE LA PARTE ALQUILO TIENE DE 1-25 ATOMOS DE CARBONO, ARALQUILTIO, O HETEROCICLILTIO; O CUANDO X ES NITROGENO, R ES R1 Y R2, DONDE R1 Y R2 SON HIDROGENO, ALQUILO, ACILO, ALCOXICARBONILO, FOSFONO, ALQUILFOSFONO O DIALQUILFOSFONO, TIENEN ACTIVIDAD ANTITUMORAL VALIOSA. SE PUEDEN PREPARAR POR ACILACION DE RIZOXINA O RIZOXIN-2-ENO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16815288 | 1988-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058535T3 true ES2058535T3 (es) | 1994-11-01 |
Family
ID=15862784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89306893T Expired - Lifetime ES2058535T3 (es) | 1988-07-06 | 1989-07-06 | Derivados de rizoxina y su utilizacion como agentes anti-tumorales. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5391564A (es) |
EP (1) | EP0350315B1 (es) |
JP (1) | JPH02131484A (es) |
KR (1) | KR940008426B1 (es) |
CN (1) | CN1028427C (es) |
AT (1) | ATE90679T1 (es) |
CA (1) | CA1334757C (es) |
DE (1) | DE68907141T2 (es) |
ES (1) | ES2058535T3 (es) |
IE (1) | IE64789B1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1334757C (en) * | 1988-07-06 | 1995-03-14 | Masakatsu Kaneko | Rhizoxin derivatives and their use as anti-tumor agents |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH20405A (en) * | 1983-07-21 | 1987-01-05 | Fujisawa Pharmaceutical Co | Anti-tumor agent container fr.900216 substance or its pharmaceutically acceptable salts thereof |
JPS6084220A (ja) * | 1983-10-17 | 1985-05-13 | Norin Suisansyo Nogyo Kankyo Gijutsu Kenkyusho | 植物病原菌リゾ−プス・キネンシスの代謝産物リゾキシンを有効成分とする抗腫瘍剤 |
CA1271763A (en) * | 1985-02-28 | 1990-07-17 | Shigenobu Okuda | Rhizoxin derivatives, their preparation and pharmaceutical use |
JPH07116198B2 (ja) * | 1987-04-02 | 1995-12-13 | 三共株式会社 | リゾキシン誘導体 |
CA1334757C (en) * | 1988-07-06 | 1995-03-14 | Masakatsu Kaneko | Rhizoxin derivatives and their use as anti-tumor agents |
JPH02196789A (ja) * | 1989-01-25 | 1990-08-03 | Sankyo Co Ltd | リゾキシン類化合物の安定化法 |
-
1989
- 1989-07-05 CA CA000604861A patent/CA1334757C/en not_active Expired - Fee Related
- 1989-07-05 JP JP1173681A patent/JPH02131484A/ja active Pending
- 1989-07-06 KR KR89009656A patent/KR940008426B1/ko not_active IP Right Cessation
- 1989-07-06 ES ES89306893T patent/ES2058535T3/es not_active Expired - Lifetime
- 1989-07-06 AT AT89306893T patent/ATE90679T1/de active
- 1989-07-06 EP EP89306893A patent/EP0350315B1/en not_active Expired - Lifetime
- 1989-07-06 DE DE89306893T patent/DE68907141T2/de not_active Expired - Fee Related
- 1989-07-06 IE IE218489A patent/IE64789B1/xx not_active IP Right Cessation
- 1989-07-06 CN CN89106717A patent/CN1028427C/zh not_active Expired - Fee Related
-
1994
- 1994-02-14 US US08/195,574 patent/US5391564A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IE64789B1 (en) | 1995-09-06 |
KR940008426B1 (en) | 1994-09-14 |
EP0350315B1 (en) | 1993-06-16 |
DE68907141T2 (de) | 1994-01-27 |
KR900001703A (ko) | 1990-02-27 |
ATE90679T1 (de) | 1993-07-15 |
CN1028427C (zh) | 1995-05-17 |
EP0350315A1 (en) | 1990-01-10 |
CN1040982A (zh) | 1990-04-04 |
DE68907141D1 (de) | 1993-07-22 |
CA1334757C (en) | 1995-03-14 |
US5391564A (en) | 1995-02-21 |
JPH02131484A (ja) | 1990-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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