ES2058030A1 - Procedure for preparing 1-[(2S)-methyl-3- mercaptopropionyl]pyrrolidine-(2S)-carboxylic acid - Google Patents
Procedure for preparing 1-[(2S)-methyl-3- mercaptopropionyl]pyrrolidine-(2S)-carboxylic acidInfo
- Publication number
- ES2058030A1 ES2058030A1 ES09300495A ES9300495A ES2058030A1 ES 2058030 A1 ES2058030 A1 ES 2058030A1 ES 09300495 A ES09300495 A ES 09300495A ES 9300495 A ES9300495 A ES 9300495A ES 2058030 A1 ES2058030 A1 ES 2058030A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrrolidine
- methyl
- carboxylic acid
- mercaptopropionyl
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to a new procedure for preparing 1-[(2S)-methyl-3-mercaptopropionyl]pyrrolidine-(2S)- carboxylic acid of formula I, in which the 1-[(2S)-methyl- 3-thiocyanatopropionyl]pyrrolidine-(2S)-carboxylic acid of formula II is dissolved in an aqueous mineral acid, the solution obtained is diluted with water and the 1- [(2S)-methyl-3-carbamoylthiopropionyl]-pyrrolidine-(2S)- carboxylic acid of formula III which is formed is hydrolysed with an aqueous solution of a base. The compound obtained according to the invention is applicable for the treatment of hypertension.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9200838A HUT64965A (en) | 1992-03-13 | 1992-03-13 | Process for the production of 2-imino-selenazolydes and medical preparations containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2058030A1 true ES2058030A1 (en) | 1994-10-16 |
ES2058030B1 ES2058030B1 (en) | 1995-10-01 |
Family
ID=10981539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9300495A Expired - Fee Related ES2058030B1 (en) | 1992-03-13 | 1993-03-11 | PROCEDURE FOR PREPARING ACID 1- ((2S) -METIL-3-MERCAPTOPROPIONIL-PIRROLIDINA- (2S) -CARBOXILICO. |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2058030B1 (en) |
HU (1) | HUT64965A (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8101548A1 (en) * | 1979-11-21 | 1980-12-16 | Farmaceutico Quimico Lab | Procedure for obtaining a proline derivative (Machine-translation by Google Translate, not legally binding) |
ES8105280A1 (en) * | 1980-04-24 | 1981-05-16 | Inke Sa | Procedure for the obtaining of N- (d-3-mercapto-2-metilpropionil) l-prolin. (Machine-translation by Google Translate, not legally binding) |
ES8200340A1 (en) * | 1979-12-29 | 1981-11-16 | Egyt Gyogyszervegyeszeti Gyar | Process for the preparation of 1-[3-mercapto-(2S)-methylpropionyl]-pyrrolidine-(2S)-carboxylic acid |
ES8604514A1 (en) * | 1985-04-10 | 1986-02-01 | Farmhispania | Mercapto methyl-propanoyl proline |
ES8706626A1 (en) * | 1986-06-21 | 1987-07-01 | Salvat | Mercapto-iso-butyramide deriv. prepn. |
-
1992
- 1992-03-13 HU HU9200838A patent/HUT64965A/en unknown
-
1993
- 1993-03-11 ES ES9300495A patent/ES2058030B1/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8101548A1 (en) * | 1979-11-21 | 1980-12-16 | Farmaceutico Quimico Lab | Procedure for obtaining a proline derivative (Machine-translation by Google Translate, not legally binding) |
ES8200340A1 (en) * | 1979-12-29 | 1981-11-16 | Egyt Gyogyszervegyeszeti Gyar | Process for the preparation of 1-[3-mercapto-(2S)-methylpropionyl]-pyrrolidine-(2S)-carboxylic acid |
ES8105280A1 (en) * | 1980-04-24 | 1981-05-16 | Inke Sa | Procedure for the obtaining of N- (d-3-mercapto-2-metilpropionil) l-prolin. (Machine-translation by Google Translate, not legally binding) |
ES8604514A1 (en) * | 1985-04-10 | 1986-02-01 | Farmhispania | Mercapto methyl-propanoyl proline |
ES8706626A1 (en) * | 1986-06-21 | 1987-07-01 | Salvat | Mercapto-iso-butyramide deriv. prepn. |
Also Published As
Publication number | Publication date |
---|---|
HUT64965A (en) | 1994-03-28 |
ES2058030B1 (en) | 1995-10-01 |
HU9200838D0 (en) | 1992-05-28 |
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Legal Events
Date | Code | Title | Description |
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PA2A | Conversion into utility model |
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FD1A | Patent lapsed |
Effective date: 19990201 |