ES2056173T3 - Analisis de lipoproteina en sangre por resonancia magnetica nuclear. - Google Patents

Analisis de lipoproteina en sangre por resonancia magnetica nuclear.

Info

Publication number
ES2056173T3
ES2056173T3 ES89116979T ES89116979T ES2056173T3 ES 2056173 T3 ES2056173 T3 ES 2056173T3 ES 89116979 T ES89116979 T ES 89116979T ES 89116979 T ES89116979 T ES 89116979T ES 2056173 T3 ES2056173 T3 ES 2056173T3
Authority
ES
Spain
Prior art keywords
magnetic resonance
nuclear magnetic
blood lipoprotein
lipoprotein analysis
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89116979T
Other languages
English (en)
Inventor
James D Otvos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2056173T3 publication Critical patent/ES2056173T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/92—Computer assisted medical diagnostics
    • Y10S128/922—Computer assisted medical diagnostics including image analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

METODO Y APARATO PARA DETERMINAR, EN UN ANALISIS DE PLASMA SANGUINEO, LA CONCENTRACION DE LOS COMPONENETES DE LIPOPROTEINA, VLDL, LDL, HDL Y PROTEINAS INCLUIDAS, OBTENIDA POR EL MOVIMIENTO DEL ESPECTRO QUIMICO DEL NMR DE UNA MUESTRA. TOMANDO COMO REFERENCIA EL ESPECTRO NMR DE LA LIPOPROTEINA Y LOS COMPONENTES SE JUNTAN PARA FORMAR UNA LINEA DE DESARROLLO QUE MIDA EL REGISTRO SUPERIOR DEL ESPECTRO NMR DEL PLASMA SANGUINEO, Y DESPUES DE ESTO QUEDA DETERMINADA LA CONCENTRACION DE CADA LIPOPROTEINA Y CONSTITUYENTES EN EL PLASMA SANGUINEO.
ES89116979T 1988-09-26 1989-09-13 Analisis de lipoproteina en sangre por resonancia magnetica nuclear. Expired - Lifetime ES2056173T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/248,750 US4933844A (en) 1988-09-26 1988-09-26 Measurement of blood lipoprotein constituents by analysis of data acquired from an NMR spectrometer

Publications (1)

Publication Number Publication Date
ES2056173T3 true ES2056173T3 (es) 1994-10-01

Family

ID=22940515

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89116979T Expired - Lifetime ES2056173T3 (es) 1988-09-26 1989-09-13 Analisis de lipoproteina en sangre por resonancia magnetica nuclear.

Country Status (6)

Country Link
US (1) US4933844A (es)
EP (1) EP0361214B1 (es)
JP (1) JP3059181B2 (es)
CA (1) CA1327993C (es)
DE (1) DE68916729T2 (es)
ES (1) ES2056173T3 (es)

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US5192264A (en) * 1989-10-06 1993-03-09 The Beth Israel Hospital Association Methods and apparatus for treating disease states using oxidized lipoproteins
CA2071638A1 (en) * 1989-12-21 1991-06-22 Eric T. Fossel Method for predicting atherosclerotic risk
SE9001698L (sv) * 1990-05-10 1991-11-11 Chiscan Ab En metod foer att upptaecka maligniteter
US5207715A (en) * 1990-07-24 1993-05-04 The Beth Israel Hospital Association Method of detecting cancer by measuring lipid-peroxidation using NMR
AU2384292A (en) * 1991-07-30 1993-03-02 North Carolina State University Method and apparatus for measuring blood lipoprotein levels by nmr spectroscopy
WO1993021517A1 (en) * 1992-04-10 1993-10-28 The Beth Israel Hospital Association Measurement of propensity to atherosclerosis; oxidizability of olefinic residues of plasma lipoproteins and lipids
WO1994007146A1 (en) * 1992-09-24 1994-03-31 Perseptive Biosystems, Inc. Quantitative measurement of ldl
US6104191A (en) * 1998-03-17 2000-08-15 General Electric Company Quantitative in vivo spectroscopy using oversampling, waterline referencing, and prior knowledge fitting
US6653140B2 (en) 1999-02-26 2003-11-25 Liposcience, Inc. Methods for providing personalized lipoprotein-based risk assessments
WO2000051054A1 (en) 1999-02-26 2000-08-31 Lipomed, Inc. Methods, systems, and computer program products for analyzing and presenting risk assessment results based on nmr lipoprotein analysis of blood
US6518069B1 (en) 1999-04-22 2003-02-11 Liposcience, Inc. Methods and computer program products for determining risk of developing type 2 diabetes and other insulin resistance related disorders
CA2331116A1 (en) * 2001-01-15 2002-07-15 Chenomx, Inc. Compound identification and quantitation in liquid mixtures -- method and process using an automated nuclear magnetic resonance measurement system
GB2410559B (en) * 2001-01-15 2005-09-28 Chenomx Inc Process, apparatus, media and signals for automatically identifying compounds in a sample
US20030028093A1 (en) * 2001-04-20 2003-02-06 Yong Ke Exponential decay modeling in spectroscopy
WO2003012416A1 (en) * 2001-08-01 2003-02-13 Liposcience, Inc. Method of determining presence and concentration of lipoprotein x in blood plasma and serum
US7259018B2 (en) * 2001-11-13 2007-08-21 The Regents Of The University Of California Ion mobility analysis of lipoproteins
AU2003285926A1 (en) * 2002-10-25 2004-05-25 Liposcience, Inc. Methods, systems and computer programs for deconvolving the spectral contribution of chemical constituents with overlapping signals
JP2007511749A (ja) * 2003-10-23 2007-05-10 リポサイエンス，インコーポレイテッド 個別サイズのｌｄｌ（低比重リポ蛋白）サブクラス粒子の生体内での濃度勾配を考慮する数理モデルを使用してｃｈｄ（冠状動脈性心臓疾患）のリスクを評価する方法、システムおよびコンピュータプログラム
US8013602B2 (en) * 2004-04-01 2011-09-06 Liposcience, Inc. NMR clinical analyzers and related methods, systems, modules and computer program products for clinical evaluation of biosamples
US7064544B1 (en) * 2004-05-18 2006-06-20 General Electric Company Method and system of scaling MR spectroscopic data acquired with phased-array coils
DE102004026903B4 (de) * 2004-06-01 2006-05-18 Universität Regensburg Verfahren zur Bestimmung von Lipoproteinen in Körperflüssigkeiten und Messanordnung dafür
US20070207516A1 (en) * 2005-12-21 2007-09-06 Doupe Thomas H Cholesterol measurement system and method
WO2007133593A2 (en) * 2006-05-10 2007-11-22 Liposcience, Inc. Methods, systems and computer programs for assessing chd risk using weighted hdl particle number measurements
US8247235B2 (en) 2007-06-08 2012-08-21 Quest Diagnostics Investments Incorporated Lipoprotein analysis by differential charged-particle mobility
US20080302666A1 (en) * 2007-06-08 2008-12-11 Benner W Henry Apparatus for differential charged-particle mobility
US9354200B1 (en) 2008-08-07 2016-05-31 Quest Diagnostics Investments Incorporated Detection apparatus for differential-charged particle mobility analyzer
AU2009308124B2 (en) * 2008-10-20 2014-12-11 Liposcience, Inc. Lipoprotein insulin resistance indexes and related methods, systems and computer programs for generating same
DE102009026651A1 (de) 2009-06-02 2011-02-17 Großmann, Kay, Dr. rer. nat. (Chemie) Verfahren und Messvorrichtung zur qualitativen und quantitativen Analyse von Körperflüssigkeiten
EP2270530B1 (en) * 2009-07-01 2013-05-01 Københavns Universitet Method for prediction of lipoprotein content from NMR data
WO2011011267A1 (en) 2009-07-22 2011-01-27 Eli Lilly And Company Method for predicting weight gain associated with a pharmaceutical therapy
US9250211B2 (en) 2010-12-30 2016-02-02 Quest Diagnostics Investments Incorporated Magnetic separation of lipoproteins using dextran sulfate
US9483612B2 (en) 2012-04-27 2016-11-01 Liposcience, Inc. CHD risk stratification evaluations for subjects with high levels of large HDL-P
US9470771B2 (en) 2012-06-08 2016-10-18 Liposcience, Inc. NMR measurements of NMR biomarker GlycA
US9361429B2 (en) 2012-06-08 2016-06-07 Liposcience, Inc. Multi-parameter diabetes risk evaluations
US9928345B2 (en) 2012-06-08 2018-03-27 Liposciences, Inc. Multiple-marker risk parameters predictive of conversion to diabetes
WO2014059025A1 (en) 2012-10-09 2014-04-17 Liposcience, Inc. Nmr quantification of branched chain amino acids
US9551768B2 (en) 2013-03-15 2017-01-24 East Carolina University NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
US20150260631A1 (en) * 2014-03-17 2015-09-17 Health Diagnostic Laboratory, Inc. System and method for assessing quanitites or sizes of lipoprotein particles from lipoprotein particle compositions
EP3021874B1 (en) * 2013-07-18 2022-04-27 The University of Hong Kong Methods for classifying pleural fluid
DK3074775T3 (en) * 2013-11-27 2018-10-01 Inst Dinvestigacio Sanitaria Pere Virgili Method for characterizing lipoproteins
US9952232B2 (en) 2014-09-11 2018-04-24 Liposcience, Inc. Cardiovascular risk evaluations using a risk parameter that includes an HDL and inflammatory biomarker interaction parameter
EP3258285B1 (en) 2016-06-14 2020-10-21 Bruker BioSpin GmbH Method for predicting chemical shift values of nmr spin systems in a sample of a fluid class, in particular in a sample of a biofluid
DE102016224691A1 (de) 2016-12-12 2018-06-14 Numares Ag Verfahren zur Analyse eines NMR-Spektrums einer lipoproteinhaltigen Probe
WO2019051226A1 (en) * 2017-09-07 2019-03-14 Liposcience, Inc. METABOLIC VULNERABILITY INDEX ASSESSMENTS WITH MULTIPLE PARAMETERS
US11467171B2 (en) 2017-11-10 2022-10-11 Liposcience, Inc. Methods and systems to detect and quantify the amount of LP-X and other abnormal lipoproteins in a biosample using NMR spectroscopy
EP3877767A1 (en) 2018-11-08 2021-09-15 Liposcience, Inc. Methods to predict liver disease mortality using lipoprotein lp-z
DE102023110285B3 (de) 2023-04-21 2024-05-08 Universität zu Lübeck, Körperschaft des öffentlichen Rechts Nmr-messung von glykoproteinen

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DE3617161A1 (de) * 1986-05-22 1987-11-26 Boehringer Mannheim Gmbh System zur bestimmung der konzentration von bestandteilen von koerperfluessigkeiten

Also Published As

Publication number Publication date
DE68916729T2 (de) 1994-12-08
US4933844A (en) 1990-06-12
CA1327993C (en) 1994-03-22
EP0361214B1 (en) 1994-07-13
JP3059181B2 (ja) 2000-07-04
DE68916729D1 (de) 1994-08-18
JPH02116743A (ja) 1990-05-01
EP0361214A1 (en) 1990-04-04

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