ES2055146T3 - Inmunoadsorbente con bajo indice de desprendimiento y su procedimiento de obtencion. - Google Patents
Inmunoadsorbente con bajo indice de desprendimiento y su procedimiento de obtencion.Info
- Publication number
- ES2055146T3 ES2055146T3 ES89430029T ES89430029T ES2055146T3 ES 2055146 T3 ES2055146 T3 ES 2055146T3 ES 89430029 T ES89430029 T ES 89430029T ES 89430029 T ES89430029 T ES 89430029T ES 2055146 T3 ES2055146 T3 ES 2055146T3
- Authority
- ES
- Spain
- Prior art keywords
- avidin
- antibody
- release
- procedure
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
ESTE INMUNOADSORBENTE CONTIENE UN ANTICUERPO POLIBIOTINILADO POR DOS CADENAS QUE TIENEN CADA UNA UN RADICAL BIOTINILO Y AVIDINO UNIDO DE FORMA COVALENTE A UN SOPORTE CROMATOGRAFICO. EL AVIDINO FIJA POR LO MENOS UNA CADENA DE ANTICUERPOS POR UNA UNION DE ALTA AFINIDAD DEL TIPO AVIDINO-BIOTINA, PERO CONSERVA PUNTOS LIBRES, RECEPTORES POTENCIALES DE RADICALES BIOTINILO. ASI, TODO ANTICUERPO O FRAGMENTO DE ESTE QUE SE DESPRENDE DEL SOPORTE ES CAPTURADO INMEDIATAMENTE POR UN PUNTO LIBRE AVIDINO. EL PROCEDIMIENTO PARA LA OBTENCION DE UN INMUNOADSORBENTE SEGUN LA INVENCION CONSISTE EN MEZCLAR UN ANTICUERPO POLIBIOTINILADO CON UN EXCESO DE AVIDINO INJERTADO SOBRE UN SOPORTE CROMATOGRAFICO. APLICACION A LA OBTENCION DE ANTIGENOS DE GRAN PUREZA Y DE SUEROS CERO EN ANTIGENO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8813776A FR2638099B1 (fr) | 1988-10-20 | 1988-10-20 | Immunoadsorbant a faible taux de relargage et son procede d'obtention |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2055146T3 true ES2055146T3 (es) | 1994-08-16 |
Family
ID=9371176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89430029T Expired - Lifetime ES2055146T3 (es) | 1988-10-20 | 1989-10-16 | Inmunoadsorbente con bajo indice de desprendimiento y su procedimiento de obtencion. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0365449B1 (es) |
JP (1) | JPH02164445A (es) |
AT (1) | ATE89925T1 (es) |
CA (1) | CA2000440A1 (es) |
DE (1) | DE68906758T2 (es) |
ES (1) | ES2055146T3 (es) |
FR (1) | FR2638099B1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5691152A (en) * | 1995-11-09 | 1997-11-25 | E. R. Squibb & Sons, Inc. | Stable avidin composition |
US6551794B1 (en) * | 1995-11-09 | 2003-04-22 | E. R. Squibb & Sons, Inc. | Stable biotinylated biomolecule composition |
US7842475B2 (en) * | 2008-01-08 | 2010-11-30 | Siemens Healthcare Diagnostics Inc. | Stabilization of solid support assay reagents |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4539249A (en) * | 1983-09-06 | 1985-09-03 | Textile Products, Incorporated | Method and apparatus for producing blends of resinous, thermoplastic fiber, and laminated structures produced therefrom |
US4582810A (en) * | 1983-09-30 | 1986-04-15 | Becton, Dickinson And Company | Immuno-agglutination particle suspensions |
FR2571498B1 (fr) * | 1984-10-04 | 1988-04-08 | Immunotech Sa | Procede de separation de cellules utilisant des anticorps et des billes de faible densite |
FR2601455B1 (fr) * | 1986-07-11 | 1989-08-04 | Stallergenes Lab | Nouveaux reactifs biologiques en phase solide et leur procede d'obtention |
-
1988
- 1988-10-20 FR FR8813776A patent/FR2638099B1/fr not_active Expired - Lifetime
-
1989
- 1989-10-11 CA CA002000440A patent/CA2000440A1/fr not_active Abandoned
- 1989-10-16 AT AT89430029T patent/ATE89925T1/de not_active IP Right Cessation
- 1989-10-16 EP EP89430029A patent/EP0365449B1/fr not_active Expired - Lifetime
- 1989-10-16 ES ES89430029T patent/ES2055146T3/es not_active Expired - Lifetime
- 1989-10-16 DE DE89430029T patent/DE68906758T2/de not_active Expired - Fee Related
- 1989-10-18 JP JP1271412A patent/JPH02164445A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE68906758T2 (de) | 1993-10-07 |
FR2638099A1 (fr) | 1990-04-27 |
EP0365449B1 (fr) | 1993-05-26 |
FR2638099B1 (fr) | 1991-01-25 |
JPH02164445A (ja) | 1990-06-25 |
DE68906758D1 (de) | 1993-07-01 |
CA2000440A1 (fr) | 1990-04-20 |
ATE89925T1 (de) | 1993-06-15 |
EP0365449A1 (fr) | 1990-04-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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